Michael Glantz, MD, PhD - Penn State Cancer Institute
Researcher Profile
Michael Glantz, MD, PhD
Professor, Department of Neurosurgery
Professor, Department of Medicine
Penn State Neuroscience Institute
Professor, Department of Medicine
Penn State Neuroscience Institute
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Brain and Central Nervous System Cancer Team
Research Interests
- Neoplasms
- Therapeutics
- Cerebrospinal Fluid
- Drug Therapy
- Brain Neoplasms
- Glioblastoma
- Survival
- Glioma
- Radiotherapy
- Meningitis
- Brain
- Neoplasm Metastasis
Clinical Trials
A biospecimen collection study to evaluate the pharmacokinetic,pharmacodynamic, and resistance profile to trametinib and dabrafenib in BRAF-V600E mutated recurrent gliomas
Phase II Pilot RCT to assess feasibility of supra-marginal surgical resection of malignant glioma (G-SUMIT: Glioma Supra Marginal Incision Trial)
Molecular Genetic, Host-Derived and Clinical Determinants of Long-Term Survival in Glioblastoma
3D-PREDICT Registry: 3D Prediction of patient-specific Response using ex vivo Interrogation of live cells from tumors
An open-label phase II study to investigate the efficacy, safety, and pharmacokinetics of tirabrutinib in patients with Primary Central Nervous System Lymphoma (PCNSL)
Recent Publications
2024
Cioffi, G, Waite, KA, Dmukauskas, M, Glantz, M, Aulakh, S, Nicolaides, T, Sengupta, S, Xiu, J & Barnholtz-Sloan, JS 2024, 'Sex differences in glioblastoma response to treatment: Impact of MGMT methylation', Neuro-Oncology Advances, vol. 6, no. 1, vdae031. https://doi.org/10.1093/noajnl/vdae031
2023
Johnson, M, Bell, A, Lauing, KL, Ladomersky, E, Zhai, L, Penco-Campillo, M, Shah, Y, Mauer, E, Xiu, J, Nicolaides, T, Drumm, M, McCortney, K, Elemento, O, Kim, M, Bommi, P, Low, JT, Memon, R, Wu, J, Zhao, J, Mi, X, Glantz, MJ, Sengupta, S, Castro, B, Yamini, B, Horbinski, C, Baker, DJ, Walunas, TL, Schiltz, GE, Lukas, RV & Wainwright, DA 2023, 'Advanced Age in Humans and Mouse Models of Glioblastoma Show Decreased Survival from Extratumoral Influence', Clinical Cancer Research, vol. 29, no. 23, pp. 4973-4989. https://doi.org/10.1158/1078-0432.CCR-23-0834
Ranjan, T, Sengupta, S, Glantz, MJ, Green, RM, Yu, A, Aregawi, D, Chaudhary, R, Chen, R, Zuccarello, M, Lu-Emerson, C, Moulding, HD, Belman, N, Glass, J, Mammoser, A, Anderson, M, Valluri, J, Marko, N, Schroeder, J, Jubelirer, S, Chow, F, Claudio, PP, Alberico, AM, Lirette, ST, Denning, KL & Howard, CM 2023, 'Cancer stem cell assay-guided chemotherapy improves survival of patients with recurrent glioblastoma in a randomized trial', Cell Reports Medicine, vol. 4, no. 5, 101025. https://doi.org/10.1016/j.xcrm.2023.101025
Darabi, S, Xiu, J, Samec, T, Kesari, S, Carrillo, J, Aulakh, S, Walsh, KM, Sengupta, S, Sumrall, A, Spetzler, D, Glantz, M & Demeure, MJ 2023, 'Capicua (CIC) mutations in gliomas in association with MAPK activation for exposing a potential therapeutic target', Medical Oncology, vol. 40, no. 7, 197. https://doi.org/10.1007/s12032-023-02071-0
Zuccato, JA, Patil, V, Mansouri, S, Voisin, M, Chakravarthy, A, Yi Shen, S, Nassiri, F, Mikolajewicz, N, Trifoi, M, Skakodub, A, Zacharia, B, Glantz, M, De Carvalho, DD, Mansouri, A & Zadeh, G 2023, 'Cerebrospinal fluid methylome-based liquid biopsies for accurate malignant brain neoplasm classification', Neuro-oncology, vol. 25, no. 8, pp. 1452-1460. https://doi.org/10.1093/neuonc/noac264
Agrawal, P, David, KA, Chen, Z, Sundaram, S, Kim, SH, Vaca, R, Lin, Y, Singer, S, Malecek, MK, Carter, J, Zayac, A, Kim, MS, Reddy, N, Ney, D, Habib, A, Strouse, C, Graber, J, Bachanova, V, Salman, S, Vendiola, JA, Hossain, N, Tsang, M, Major, A, Gandhi, MK, Keane, C, Bond, DA, Folstad, M, Chang, J, Mier-Hicks, A, Torka, P, Rajakumar, P, Venugopal, P, Berg, S, Glantz, M, Goldlust, SA, Matnani, R, Kumar, P, Ollila, TA, Cai, J, Spurgeon, SE, Sieg, AG, Cleveland, J, Epperla, N, Karmali, R, Naik, S, Smith, SM, Rubenstein, JL, Kahl, BS, Chadburn, A, Evens, AM & Martin, P 2023, 'EBV-positive PCNSL in older patients: incidence, characteristics, tumor pathology, and outcomes across a large multicenter cohort', Leukemia and Lymphoma, vol. 64, no. 5, pp. 1026-1034. https://doi.org/10.1080/10428194.2023.2191152
Hertler, C, Felsberg, J, Gramatzki, D, Le Rhun, E, Clarke, J, Soffietti, R, Wick, W, Chinot, O, Ducray, F, Roth, P, McDonald, K, Hau, P, Hottinger, AF, Reijneveld, J, Schnell, O, Marosi, C, Glantz, M, Darlix, A, Lombardi, G, Krex, D, Glas, M, Reardon, DA, van den Bent, M, Lefranc, F, Herrlinger, U, Razis, E, Carpentier, AF, Phillips, S, Rudà, R, Wick, A, Tabouret, E, Meyronet, D, Maurage, CA, Rushing, E, Rapkins, R, Bumes, E, Hegi, M, Weyerbrock, A, Aregawi, D, Gonzalez-Gomez, C, Pellerino, A, Klein, M, Preusser, M, Bendszus, M, Golfinopoulos, V, von Deimling, A, Gorlia, T, Wen, PY, Reifenberger, G & Weller, M 2023, 'Long-term survival with IDH wildtype glioblastoma: first results from the ETERNITY Brain Tumor Funders’ Collaborative Consortium (EORTC 1419)', European Journal of Cancer, vol. 189, 112913. https://doi.org/10.1016/j.ejca.2023.05.002
David, KA, Sundaram, S, Kim, SH, Vaca, R, Lin, Y, Singer, S, Malecek, MK, Carter, J, Zayac, A, Kim, MS, Reddy, N, Ney, D, Habib, A, Strouse, C, Graber, J, Bachanova, V, Salman, S, Vendiola, JA, Hossain, N, Tsang, M, Major, A, Bond, DA, Agrawal, P, Mier-Hicks, A, Torka, P, Rajakumar, P, Venugopal, P, Berg, S, Glantz, M, Goldlust, SA, Folstad, M, Kumar, P, Ollila, TA, Cai, J, Spurgeon, S, Sieg, A, Cleveland, J, Chang, J, Epperla, N, Karmali, R, Naik, S, Martin, P, Smith, SM, Rubenstein, J, Kahl, B & Evens, AM 2023, 'Older patients with primary central nervous system lymphoma: Survival and prognostication across 20 U.S. cancer centers', American Journal of Hematology, vol. 98, no. 6, pp. 900-912. https://doi.org/10.1002/ajh.26919
Douville, C, Curtis, S, Summers, M, Azad, TD, Rincon-Torroella, J, Wang, Y, Mattox, A, Avigdor, B, Dudley, J, Materi, J, Raj, D, Nair, S, Bhanja, D, Tuohy, K, Dobbyn, L, Popoli, M, Ptak, J, Nehme, N, Silliman, N, Blair, C, Judge, K, Gallia, GL, Groves, M, Jackson, CM, Jackson, EM, Laterra, J, Lim, M, Mukherjee, D, Weingart, J, Naidoo, J, Koschmann, C, Smith, N, Schreck, KC, Pardo, CA, Glantz, M, Holdhoff, M, Kinzler, KW, Papadopoulos, N, Vogelstein, B & Bettegowda, C 2023, 'Seq-ing the SINEs of central nervous system tumors in cerebrospinal fluid', Cell Reports Medicine, vol. 4, no. 8, 101148. https://doi.org/10.1016/j.xcrm.2023.101148
2022
Hallan, DR, Nguyen, AM, Liang, M, McNutt, S, Goss, M, Bell, E, Natarajan, S, Nichol, A, Messner, C, Bracken, E & Glantz, M 2022, 'Charting the course from abstract to published article', Journal of neurosurgery, vol. 136, no. 6, pp. 1773-1780. https://doi.org/10.3171/2021.7.JNS2128
Mikolajewicz, N, Khan, S, Trifoi, M, Skakdoub, A, Ignatchenko, V, Mansouri, S, Zuccatto, J, Zacharia, BE, Glantz, M, Zadeh, G, Moffat, J, Kislinger, T & Mansouri, A 2022, 'Leveraging the CSF proteome toward minimally-invasive diagnostics surveillance of brain malignancies', Neuro-Oncology Advances, vol. 4, no. 1, vdac161. https://doi.org/10.1093/noajnl/vdac161
Le Rhun, E, Devos, P, Winklhofer, S, Lmalem, H, Brandsma, D, Kumthekar, P, Castellano, A, Compter, A, Dhermain, F, Franceschi, E, Forsyth, P, Furtner, J, Galldiks, N, Pérez-Larraya, JG, Gempt, J, Hattingen, E, Hempel, JM, Lukacova, S, Minniti, G, O’Brien, B, Postma, TJ, Roth, P, Rudà, R, Schaefer, N, Schmidt, NO, Snijders, TJ, Thust, S, van den Bent, M, van der Hoorn, A, Vogin, G, Smits, M, Tonn, JC, Jaeckle, KA, Preusser, M, Glantz, M, Wen, PY, Bendszus, M & Weller, M 2022, 'Prospective validation of a new imaging scorecard to p g j and RANO effort', Neuro-oncology, vol. 24, no. 10, pp. 1726-1735. https://doi.org/10.1093/neuonc/noac043
Yee, PP, Wang, J, Chih, SY, Aregawi, DG, Glantz, MJ, Zacharia, BE, Thamburaj, K & Li, W 2022, 'Temporal radiographic and histological study of necrosis development in a mouse glioblastoma model', Frontiers in Oncology, vol. 12, 993649. https://doi.org/10.3389/fonc.2022.993649
2021
Halper-Stromberg, E, McCall, CM, Haley, LM, Lin, MT, Vogt, S, Gocke, CD, Eshleman, JR, Stevens, W, Martinson, NA, Epeldegui, M, Holdhoff, M, Bettegowda, C, Glantz, MJ, Ambinder, RF & Xian, RR 2021, 'CloneRetriever: An Automated Algorithm to Identify Clonal B and T Cell Gene Rearrangements by Next-Generation Sequencing for the Diagnosis of Lymphoid Malignancies', Clinical chemistry, vol. 67, no. 11, pp. 1524-1533. https://doi.org/10.1093/clinchem/hvab141
Taslimi, S, Brar, K, Ellenbogen, Y, Deng, J, Hou, W, Moraes, FY, Glantz, M, Zacharia, BE, Tan, A, Ahluwalia, MS, Khasraw, M, Zadeh, G & Mansouri, A 2021, 'Comparative Efficacy of Systemic Agents for Brain Metastases From Non-Small-Cell Lung Cancer With an EGFR Mutation/ALK Rearrangement: A Systematic Review and Network Meta-Analysis', Frontiers in Oncology, vol. 11, 739765. https://doi.org/10.3389/fonc.2021.739765
Brar, K, Taslimi, S, Ellenbogen, Y, Deng, J, Hou, W, Moraes, FY, Glantz, M, Zacharia, BE, Tan, A, Ahluwalia, MS, Khasraw, M, Zadeh, G & Mansouri, A 2022, 'Comparative Efficacy of Treatments for Brain Metastases from Non–Small Cell Lung Cancer without an EGFR-Mutation/ALK-Rearrangement: A Systematic Review and Network Meta-Analysis', World neurosurgery, vol. 158, pp. e87-e102. https://doi.org/10.1016/j.wneu.2021.10.113
Schreck, KC, Morin, A, Zhao, G, Allen, AN, Flannery, P, Glantz, M, Green, AL, Jones, C, Jones, KL, Kilburn, LB, Nazemi, KJ, Samuel, D, Sanford, B, Solomon, DA, Wang, J, Pratilas, CA, Nicolaides, T & Levy, JMM 2021, 'Deconvoluting mechanisms of acquired resistance to RAF inhibitors in BRAFV600E-Mutant Human Glioma', Clinical Cancer Research, vol. 27, no. 22, pp. 6197-6208. https://doi.org/10.1158/1078-0432.CCR-21-2660
Mansouri, A, Padmanaban, V, Aregawi, D & Glantz, M 2021, 'VEGF and Immune Checkpoint Inhibition for Prevention of Brain Metastases: Systematic Review and Meta-analysis', Neurology, vol. 97, no. 15, pp. E1484-E1492. https://doi.org/10.1212/WNL.0000000000012642
2020
Bernstein, A, Mrowczynski, OD, Greene, A, Ryan, S, Chung, C, Zacharia, BE & Glantz, M 2020, 'Dual BRAF/MEK therapy in BRAF V600E-mutated primary brain tumors: A case series showing dramatic clinical and radiographic responses and a reduction in cutaneous toxicity', Journal of neurosurgery, vol. 133, no. 6, pp. 1704-1709. https://doi.org/10.3171/2019.8.JNS19643
Yee, PP, Wei, Y, Kim, SY, Lu, T, Chih, SY, Lawson, C, Tang, M, Liu, Z, Anderson, B, Thamburaj, K, Young, MM, Aregawi, DG, Glantz, MJ, Zacharia, BE, Specht, CS, Wang, HG & Li, W 2020, 'Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression', Nature communications, vol. 11, no. 1, 5424. https://doi.org/10.1038/s41467-020-19193-y
Glantz, M & Brandmeir, N 2020, 'When can we be positive about p values?', Journal of neurosurgery, vol. 132, no. 2, pp. 656-661. https://doi.org/10.3171/2018.10.JNS182494