Dawit Aregawi, MD - Penn State Cancer Institute
Researcher Profile
Dawit Aregawi, MD
Assistant Professor, Department of Neurosurgery
Penn State Neuroscience Institute
Penn State Neuroscience Institute
Scientific Program:Experimental Therapeutics
Disease Teams:
Cancer Institute, Brain and Central Nervous System Cancer Team
Clinical Trials
Integration of CSF proteogenomics in the diagnosis and management of diffuse gliomas
Multi-Center, Randomized, Double-Blind, Placebo-Controlled Trial Comparing Standard of Care Adjuvant Temozolomide With or Without 5-Aminolevulinic Acid (5-ALA) With Concomitant Low Intensity Diffuse Ultrasound (LIDUä) Sonodynamic Therapy (SDT) System In Patients With Newly Diagnosed Glioblastoma After Completion of Chemoradiotherapy
Penn State Hershey Brain, Skull Base, Spine and Peripheral Nervous System Tumor Registry
A Randomized, Open-label, Multicentric, Two-arm Pivotal Trial of SonoCloud-9 Combined With Carboplatin (CBDCA) vs Standard of Care Lomustine (CCNU) or Temozolomide (TMZ) in Patients Undergoing Planned Resection for First Recurrence Glioblastoma
Maintenance Obinutuzumab for Primary Central Nervous System Lymphoma Complete or Partial Responders
Recent Publications
2025
Tuohy, K, Dowd, R, Ali, A, Badani, A, Sichinga, K, Zacharia, BE, Mansouri, A, Aregawi, D & Glantz, M 2025, 'Medical Therapy Alone for Ommaya Reservoir-Associated Bacterial Meningitis: When It Works and When It Fails', Neurosurgery, vol. 97, no. 2, pp. 380-386. https://doi.org/10.1227/neu.0000000000003310
Trifoi, M, Tuohy, K, Sichinga, K, Levit, M, Zacharia, BE, Mansouri, A, Aregawi, D & Glantz, M 2026, 'Prevention of Ommaya Reservoir–Associated Bacterial Meningitis With Prophylactic Intraventricular Vancomycin', Neurosurgery, vol. 98, no. 3, pp. 643-650. https://doi.org/10.1227/neu.0000000000003647
Nayak, L, Grommes, C, Kallam, A, Peereboom, DM, Ambady, P, Mendez, JS, Aregawi, DG, Sumrall, AL, Omuro, AMP, Iwamoto, F, Dietrich, J, Umemura, Y, Munker, R, Chukwueke, UN, Schaff, L, Prados, S, Takazawa, A, Aoi, A & Batchelor, T 2025, 'Tirabrutinib for the treatment of relapsed or refractory primary central nervous system lymphoma: Efficacy and safety from the phase II PROSPECT study', Journal of Clinical Oncology, vol. 43, no. 16, 2019. https://doi.org/10.1200/JCO.2025.43.16_suppl.2019
2024
Lu, T, Yee, PP, Chih, SY, Tang, M, Chen, H, Aregawi, DG, Glantz, MJ, Zacharia, BE, Wang, H-G & Li, W 2024, 'LC3-associated phagocytosis of neutrophils triggers tumor ferroptotic cell death in glioblastoma', EMBO Journal, vol. 43, no. 13, pp. 2582-2605. https://doi.org/10.1038/s44318-024-00130-4
Mikolajewicz, N, Yee, PP, Bhanja, D, Trifoi, M, Miller, AM, Metellus, P, Bagley, SJ, Balaj, L, De MacEdo Filho, LJM, Zacharia, BE, Aregawi, D, Glantz, M, Weller, M, Ahluwalia, MS, Kislinger, T & Mansouri, SA 2024, 'Systematic Review of Cerebrospinal Fluid Biomarker Discovery in Neuro-Oncology: A Roadmap to Standardization and Clinical Application', Journal of Clinical Oncology, vol. 42, no. 16, pp. 1961-1974. https://doi.org/10.1200/JCO.23.01621
Demirsoy, S, Tran, H, Liu, J, Li, Y, Yang, S, Aregawi, D, Glantz, MJ, Jacob, NK, Walter, V, Schell, TD & Olmez, I 2024, 'Targeting Tyro3, Axl, and MerTK Receptor Tyrosine Kinases Significantly Sensitizes Triple-Negative Breast Cancer to CDK4/6 Inhibition', Cancers, vol. 16, no. 12, 2253. https://doi.org/10.3390/cancers16122253
2023
Ranjan, T, Sengupta, S, Glantz, MJ, Green, RM, Yu, A, Aregawi, D, Chaudhary, R, Chen, R, Zuccarello, M, Lu-Emerson, C, Moulding, HD, Belman, N, Glass, J, Mammoser, A, Anderson, M, Valluri, J, Marko, N, Schroeder, J, Jubelirer, S, Chow, F, Claudio, PP, Alberico, AM, Lirette, ST, Denning, KL & Howard, CM 2023, 'Cancer stem cell assay-guided chemotherapy improves survival of patients with recurrent glioblastoma in a randomized trial', Cell Reports Medicine, vol. 4, no. 5, 101025. https://doi.org/10.1016/j.xcrm.2023.101025
Hertler, C, Felsberg, J, Gramatzki, D, Le Rhun, E, Clarke, J, Soffietti, R, Wick, W, Chinot, O, Ducray, F, Roth, P, McDonald, K, Hau, P, Hottinger, AF, Reijneveld, J, Schnell, O, Marosi, C, Glantz, M, Darlix, A, Lombardi, G, Krex, D, Glas, M, Reardon, DA, van den Bent, M, Lefranc, F, Herrlinger, U, Razis, E, Carpentier, AF, Phillips, S, Rudà, R, Wick, A, Tabouret, E, Meyronet, D, Maurage, CA, Rushing, E, Rapkins, R, Bumes, E, Hegi, M, Weyerbrock, A, Aregawi, D, Gonzalez-Gomez, C, Pellerino, A, Klein, M, Preusser, M, Bendszus, M, Golfinopoulos, V, von Deimling, A, Gorlia, T, Wen, PY, Reifenberger, G & Weller, M 2023, 'Long-term survival with IDH wildtype glioblastoma: first results from the ETERNITY Brain Tumor Funders’ Collaborative Consortium (EORTC 1419)', European Journal of Cancer, vol. 189, 112913. https://doi.org/10.1016/j.ejca.2023.05.002
2022
Yee, PP, Wang, J, Chih, SY, Aregawi, DG, Glantz, MJ, Zacharia, BE, Thamburaj, K & Li, W 2022, 'Temporal radiographic and histological study of necrosis development in a mouse glioblastoma model', Frontiers in Oncology, vol. 12, 993649. https://doi.org/10.3389/fonc.2022.993649