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Researcher Profile

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Dawit Aregawi, MD

Dawit Aregawi, MD

Assistant Professor, Department of Neurosurgery
Penn State Neuroscience Institute
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Brain and Central Nervous System Cancer Team

Research Interests

  • Therapeutics
  • Glioblastoma
  • Polycystic Ovary Syndrome
  • Neoplasms
  • Diet
  • Metformin
  • Drug Therapy
  • Glioma
  • Mutation
  • Thrombophilia
  • Radiation
  • Weights and Measures

Clinical Trials

Phase II Pilot RCT to assess feasibility of supra-marginal surgical resection of malignant glioma (G-SUMIT: Glioma Supra Marginal Incision Trial)
3D-PREDICT Registry: 3D Prediction of patient-specific Response using ex vivo Interrogation of live cells from tumors
An open-label phase II study to investigate the efficacy, safety, and pharmacokinetics of tirabrutinib in patients with Primary Central Nervous System Lymphoma (PCNSL)

Recent Publications


Lu, T, Yee, PP, Chih, SY, Tang, M, Chen, H, Aregawi, DG, Glantz, MJ, Zacharia, BE, Wang, H-G & Li, W 2024, 'LC3-associated phagocytosis of neutrophils triggers tumor ferroptotic cell death in glioblastoma', EMBO Journal, vol. 43, no. 13, pp. 2582-2605.
Mikolajewicz, N, Yee, PP, Bhanja, D, Trifoi, M, Miller, AM, Metellus, P, Bagley, SJ, Balaj, L, De MacEdo Filho, LJM, Zacharia, BE, Aregawi, D, Glantz, M, Weller, M, Ahluwalia, MS, Kislinger, T & Mansouri, SA 2024, 'Systematic Review of Cerebrospinal Fluid Biomarker Discovery in Neuro-Oncology: A Roadmap to Standardization and Clinical Application', Journal of Clinical Oncology, vol. 42, no. 16, pp. 1961-1974.
Demirsoy, S, Tran, H, Liu, J, Li, Y, Yang, S, Aregawi, D, Glantz, MJ, Jacob, NK, Walter, V, Schell, T & Olmez, I 2024, 'Targeting Tyro3, Axl, and MerTK Receptor Tyrosine Kinases Significantly Sensitizes Triple-Negative Breast Cancer to CDK4/6 Inhibition', Cancers, vol. 16, no. 12, 2253.


Ranjan, T, Sengupta, S, Glantz, MJ, Green, RM, Yu, A, Aregawi, D, Chaudhary, R, Chen, R, Zuccarello, M, Lu-Emerson, C, Moulding, HD, Belman, N, Glass, J, Mammoser, A, Anderson, M, Valluri, J, Marko, N, Schroeder, J, Jubelirer, S, Chow, F, Claudio, PP, Alberico, AM, Lirette, ST, Denning, KL & Howard, CM 2023, 'Cancer stem cell assay-guided chemotherapy improves survival of patients with recurrent glioblastoma in a randomized trial', Cell Reports Medicine, vol. 4, no. 5, 101025.
Hertler, C, Felsberg, J, Gramatzki, D, Le Rhun, E, Clarke, J, Soffietti, R, Wick, W, Chinot, O, Ducray, F, Roth, P, McDonald, K, Hau, P, Hottinger, AF, Reijneveld, J, Schnell, O, Marosi, C, Glantz, M, Darlix, A, Lombardi, G, Krex, D, Glas, M, Reardon, DA, van den Bent, M, Lefranc, F, Herrlinger, U, Razis, E, Carpentier, AF, Phillips, S, Rudà, R, Wick, A, Tabouret, E, Meyronet, D, Maurage, CA, Rushing, E, Rapkins, R, Bumes, E, Hegi, M, Weyerbrock, A, Aregawi, D, Gonzalez-Gomez, C, Pellerino, A, Klein, M, Preusser, M, Bendszus, M, Golfinopoulos, V, von Deimling, A, Gorlia, T, Wen, PY, Reifenberger, G & Weller, M 2023, 'Long-term survival with IDH wildtype glioblastoma: first results from the ETERNITY Brain Tumor Funders’ Collaborative Consortium (EORTC 1419)', European Journal of Cancer, vol. 189, 112913.


Yee, PP, Wang, J, Chih, SY, Aregawi, DG, Glantz, MJ, Zacharia, BE, Thamburaj, K & Li, W 2022, 'Temporal radiographic and histological study of necrosis development in a mouse glioblastoma model', Frontiers in Oncology, vol. 12, 993649.


Fu, S, Piccioni, DE, Liu, H, Lukas, RV, Kesari, S, Aregawi, D, Hong, DS, Yamaguchi, K, Whicher, K, Zhang, Y, Chen, YL, Poola, N, Eddy, J & Blum, D 2021, 'A phase I study of the WT2725 dosing emulsion in patients with advanced malignancies', Scientific reports, vol. 11, no. 1, 22355.
Khristov, V, Shenoy, G, Mau, C, Mrowczynski, O, Rizk, E, Pu, C, Specht, CS & Aregawi, D 2022, 'Myxopapillary Ependymoma with Anaplastic Features: A Case Series and Review of the Literature', World neurosurgery, vol. 158, pp. e735-e745.
Mrowczynski, OD, Vasekar, M, Fox, E, Harbaugh, K, Aregawi, D, Pameijer, CR, Zaorsky, N, Payne, R & Rizk, E 2021, 'Spontaneous Hip Dislocation Complicating the Management of Malignant Peripheral Nerve Sheath Tumor Arising Within a Plexiform Neurofibroma', Cureus, vol. 13, no. 7, e16320.
Mansouri, A, Padmanaban, V, Aregawi, D & Glantz, M 2021, 'VEGF and Immune Checkpoint Inhibition for Prevention of Brain Metastases: Systematic Review and Meta-analysis', Neurology, vol. 97, no. 15, pp. E1484-E1492.


Yee, PP, Wei, Y, Kim, SY, Lu, T, Chih, SY, Lawson, C, Tang, M, Liu, Z, Anderson, B, Thamburaj, K, Young, MM, Aregawi, DG, Glantz, MJ, Zacharia, BE, Specht, CS, Wang, HG & Li, W 2020, 'Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression', Nature communications, vol. 11, no. 1, 5424.