William Evan Higgins, PhD - Penn State Cancer Institute
Researcher Profile
William Evan Higgins, PhD
Distinguished Professor, Electrical Engineering
Scientific Program:Next-Generation Therapies
Recent Publications
2025
He, Y & Higgins, WE 2025, Automated Detection of Central Chest Lymph Nodes for Guided Bronchoscopy. in SM Astley & A Wismuller (eds), Medical Imaging 2025: Computer-Aided Diagnosis., 134072J, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 13407, SPIE, Medical Imaging 2025: Computer-Aided Diagnosis, San Diego, United States, 2/17/25. https://doi.org/10.1117/12.3045046
Kao, A, Chang, Q, Higgins, WE, Ahmad, D, Htwe, Y, Toth, J & Bascom, R 2025, Automatic lesion detection in high-definition white-light bronchoscopic video. in BS Gimi & A Krol (eds), Medical Imaging 2025: Clinical and Biomedical Imaging., 134101A, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 13410, SPIE, Medical Imaging 2025: Clinical and Biomedical Imaging, San Diego, United States, 2/18/25. https://doi.org/10.1117/12.3045050
Chang, Q, Ahmad, D, Toth, J, Bascom, R & Higgins, WE 2025, Integrated video analysis system for autofluorescence bronchoscopy. in BS Gimi & A Krol (eds), Medical Imaging 2025: Clinical and Biomedical Imaging., 1341018, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 13410, SPIE, Medical Imaging 2025: Clinical and Biomedical Imaging, San Diego, United States, 2/18/25. https://doi.org/10.1117/12.3044383
He, Y & Higgins, WE 2025, Method for Reducing CT-to-Body Divergence Tailored to Peripheral Bronchoscopy. in ME Rettmann & JH Siewerdsen (eds), Medical Imaging 2025: Image-Guided Procedures, Robotic Interventions, and Modeling., 134081H, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 13408, SPIE, Medical Imaging 2025: Image-Guided Procedures, Robotic Interventions, and Modeling, San Diego, United States, 2/17/25. https://doi.org/10.1117/12.3040059
Daneshpajooh, V, Ahmad, D, Htwe, Y, Toth, J, Bascom, R & Higgins, WE 2025, Real-time video enhancement for narrow-band imaging bronchoscopy. in BS Gimi & A Krol (eds), Medical Imaging 2025: Clinical and Biomedical Imaging., 1341014, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 13410, SPIE, Medical Imaging 2025: Clinical and Biomedical Imaging, San Diego, United States, 2/18/25. https://doi.org/10.1117/12.3045061
Zhao, W, Kuhlengel, T, Chang, Q, Daneshpajooh, V, He, Y, Kao, A, Bascom, R, Ahmad, D, Htwe, YM, Toth, J, Schaer, T, Brewer, L, Hilliard, R & Higgins, WE 2025, 'Two-phase radial endobronchial ultrasound bronchoscopy registration', Journal of Medical Imaging, vol. 12, no. 2, 025001. https://doi.org/10.1117/1.JMI.12.2.025001
2024
Daneshpajooh, V, Ahmad, D, Toth, J, Bascom, R & Higgins, WE 2024, 'Automatic lesion detection for narrow-band imaging bronchoscopy', Journal of Medical Imaging, vol. 11, no. 3, 036002. https://doi.org/10.1117/1.JMI.11.3.036002
Kao, A & Higgins, WE 2024, Automatic procedure planning for radial-probe endobronchial ultrasound. in JH Siewerdsen & ME Rettmann (eds), Medical Imaging 2024: Image-Guided Procedures, Robotic Interventions, and Modeling., 129281P, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12928, SPIE, Medical Imaging 2024: Image-Guided Procedures, Robotic Interventions, and Modeling, San Diego, United States, 2/19/24. https://doi.org/10.1117/12.3004841
Chang, Q & Higgins, WE 2024, Self-supervised monocular depth and ego-motion estimation for CT-bronchoscopy fusion. in JH Siewerdsen & ME Rettmann (eds), Medical Imaging 2024: Image-Guided Procedures, Robotic Interventions, and Modeling., 129280B, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12928, SPIE, Medical Imaging 2024: Image-Guided Procedures, Robotic Interventions, and Modeling, San Diego, United States, 2/19/24. https://doi.org/10.1117/12.3004499
Chang, Q, Daneshpajooh, V, Byrnes, PD, Ahmad, D, Toth, J, Bascom, R & Higgins, WE 2024, Synchronization and analysis of multimodal bronchoscopic airway exams for early lung cancer detection. in JH Siewerdsen & ME Rettmann (eds), Medical Imaging 2024: Image-Guided Procedures, Robotic Interventions, and Modeling., 129281B, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12928, SPIE, Medical Imaging 2024: Image-Guided Procedures, Robotic Interventions, and Modeling, San Diego, United States, 2/19/24. https://doi.org/10.1117/12.3004212
2023
Chang, Q, Ahmad, D, Toth, J, Bascom, R & Higgins, WE 2023, ESFPNet: Efficient deep learning architecture for real-time lesion segmentation in autofluorescence bronchoscopic video. in BS Gimi & A Krol (eds), Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging., 1246803, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12468, SPIE, Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging, San Diego, United States, 2/19/23. https://doi.org/10.1117/12.2647897
He, Y & Higgins, WE 2023, Extemporaneous Airway Route Computation During Live Bronchoscopic Procedures. in CA Linte & JH Siewerdsen (eds), Medical Imaging 2023: Image-Guided Procedures, Robotic Interventions, and Modeling., 1246602, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12466, SPIE, Medical Imaging 2023: Image-Guided Procedures, Robotic Interventions, and Modeling, San Diego, United States, 2/19/23. https://doi.org/10.1117/12.2647901
Zhao, W, Kuhlengel, T, Chang, Q, Daneshpajooh, V, Schaer, T, Brewer, L, Hilliard, R, Ahmad, D, Toth, J, Bascom, R & Higgins, WE 2023, Image-Guided Radial-Probe EBUS Bronchoscopy System: Live Study Validation. in CA Linte & JH Siewerdsen (eds), Medical Imaging 2023: Image-Guided Procedures, Robotic Interventions, and Modeling., 124661O, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12466, SPIE, Medical Imaging 2023: Image-Guided Procedures, Robotic Interventions, and Modeling, San Diego, United States, 2/19/23. https://doi.org/10.1117/12.2648637
Daneshpajooh, V, Dumas, C, Ahmad, D, Toth, J, Bascom, R & Higgins, WE 2023, Vascular pattern recognition for narrow-band imaging bronchoscopy. in BS Gimi & A Krol (eds), Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging., 124680L, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12468, SPIE, Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging, San Diego, United States, 2/19/23. https://doi.org/10.1117/12.2647150
2022
Kuhlengel, TK, Bascom, R & Higgins, WE 2022, 'Efficient procedure planning for comprehensive lymph node staging bronchoscopy', Journal of Medical Imaging, vol. 9, no. 5, pp. 55001. https://doi.org/10.1117/1.JMI.9.5.055001
Zhao, W, Ahmad, D, Toth, J, Bascom, R & Higgins, WE 2023, 'Endobronchial Ultrasound Image Simulation for Image-Guided Bronchoscopy', IEEE Transactions on Biomedical Engineering, vol. 70, no. 1, pp. 318-330. https://doi.org/10.1109/TBME.2022.3190165
Zhao, W, Ahmad, D, Toth, J, Bascom, R & Higgins, WE 2022, Image-Guided System for Radial-Probe Endobronchial Ultrasound Bronchoscopy. in CA Linte & JH Siewerdsen (eds), Medical Imaging 2022: Image-Guided Procedures, Robotic Interventions, and Modeling., 120340B, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12034, SPIE, Medical Imaging 2022: Image-Guided Procedures, Robotic Interventions, and Modeling, Virtual, Online, 3/21/22. https://doi.org/10.1117/12.2612104
Kuhlengel, TK, Bascom, R & Higgins, WE 2022, Image-guided bronchoscopy for comprehensive lymph node staging. in CA Linte & JH Siewerdsen (eds), Medical Imaging 2022: Image-Guided Procedures, Robotic Interventions, and Modeling., 120342U, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12034, SPIE, Medical Imaging 2022: Image-Guided Procedures, Robotic Interventions, and Modeling, Virtual, Online, 3/21/22. https://doi.org/10.1117/12.2612203
Zang, X, Zhao, W, Toth, J, Bascom, R & Higgins, W 2022, 'Multimodal Registration for Image-Guided EBUS Bronchoscopy', Journal of Imaging, vol. 8, no. 7, 189. https://doi.org/10.3390/jimaging8070189
Daneshpajooh, V, Ahmad, D, Toth, J, Bascom, R & Higgins, WE 2022, Video Analysis Framework for Lesion Detection in Narrow Band Imaging Bronchoscopy. in BS Gimi & A Krol (eds), Medical Imaging 2022: Biomedical Applications in Molecular, Structural, and Functional Imaging., 120360M, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12036, SPIE, Medical Imaging 2022: Biomedical Applications in Molecular, Structural, and Functional Imaging, Virtual, Online, 3/21/22. https://doi.org/10.1117/12.2606054