Vladimir Spiegelman, MD, PhD - Penn State Cancer Institute
Researcher Profile
Vladimir Spiegelman, MD, PhD
Professor and THON Chair for Pediatric Cancer Research, Department of Pediatrics
Division of Hematology and Oncology
Professor, Department of Molecular and Precision Medicine
Penn State Neuroscience Institute
Division of Hematology and Oncology
Professor, Department of Molecular and Precision Medicine
Penn State Neuroscience Institute
Scientific Program:Next-Generation Therapies
Recent Publications
2025
Wallis, N, Gershon, T, Shaaby, S, Oberman, F, Grunewald, M, Duran, D, Singh, A, Vainer, G, Spiegelman, VS, Sharma, A & Yisraeli, JK 2025, 'AVJ16 inhibits lung carcinoma by targeting IGF2BP1', Oncogene, vol. 44, no. 35, pp. 3239-3254. https://doi.org/10.1038/s41388-025-03449-2
Ding, Y, He, B, Bogush, D, Schramm, J, Singh, C, Dovat, K, Randazzo, J, Tukaramrao, D, Hengst, J, Annageldiyev, C, Kudva, A, Desai, D, Sharma, A, Spiegelman, VS, Huang, S, Viet, CT, Dorsam, G, Saulnier Scholler, G, Broach, J, Yue, F & Dovat, S 2025, 'Critical roles of IKAROS and HDAC1 in regulation of heterochromatin and tumor suppression in T-cell acute lymphoblastic leukemia', Leukemia, vol. 39, no. 8, pp. 2010-2020. https://doi.org/10.1038/s41375-025-02651-1
Dhamdhere, MR, Gowda, CP, Imamura, Y, Wang, HG, Schell, TS & Spiegelman, VS 2025, 'IGF2BP1 fosters an immunosuppressive tumor microenvironment in high-risk neuroblastoma, contributing to their resistance to immunotherapy', OncoImmunology, vol. 14, no. 1, 2584408. https://doi.org/10.1080/2162402X.2025.2584408
2024
Wills, CA, Liu, X, Chen, L, Zhao, Y, Liu, Z, Spiegelman, VS, Sundstrom, J & Wang, HG 2024, 'Chemotherapy-induced small extracellular vesicles prime the pre-metastatic niche to accelerate neuroblastoma metastasis', Genes and Diseases, vol. 11, no. 4, 101017. https://doi.org/10.1016/j.gendis.2023.05.016
Singh, A, Singh, V, Wallis, N, Abis, G, Oberman, F, Wood, T, Dhamdhere, M, Gershon, T, Ramos, A, Yisraeli, J, Spiegelman, VS & Sharma, AK 2024, 'Development of a specific and potent IGF2BP1 inhibitor: A promising therapeutic agent for IGF2BP1-expressing cancers', European Journal of Medicinal Chemistry, vol. 263, 115940. https://doi.org/10.1016/j.ejmech.2023.115940
Dhamdhere, MR & Spiegelman, VS 2024, 'Extracellular vesicles in neuroblastoma: role in progression, resistance to therapy and diagnostics', Frontiers in immunology, vol. 15, 1385875. https://doi.org/10.3389/fimmu.2024.1385875
Basavaraja, R, Zhang, H, Holczbauer, Á, Lu, Z, Radaelli, E, Assenmacher, CA, George, SS, Nallamala, VC, Beiting, DP, Meyer-Ficca, ML, Meyer, RG, Guo, W, Fan, Y, Modzelewski, AJ, Spiegelman, VS, Cohen, MS & Fuchs, SY 2024, 'PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies', Cell Reports Medicine, vol. 5, no. 7, 101649. https://doi.org/10.1016/j.xcrm.2024.101649
Singh, V, Singh, A, Liu, AJ, Fuchs, SY, Sharma, A & Spiegelman, VS 2024, 'RNA Binding Proteins as Potential Therapeutic Targets in Colorectal Cancer', Cancers, vol. 16, no. 20, 3502. https://doi.org/10.3390/cancers16203502
2023
Baringer, SL, Lukacher, AS, Palsa, K, Kim, H, Lippmann, ES, Spiegelman, VS, Simpson, IA & Connor, JR 2023, 'Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood–brain barrier by altering the ratio of apo- and holo-transferrin', Journal of neurochemistry, vol. 167, no. 2, pp. 248-261. https://doi.org/10.1111/jnc.15954
Baringer, SL, Palsa, K, Spiegelman, VS, Simpson, IA & Connor, JR 2023, 'Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation', Journal of Biomedical Science, vol. 30, no. 1, 36. https://doi.org/10.1186/s12929-023-00934-2
Palsa, K, Baringer, SL, Shenoy, G, Spiegelman, VS, Simpson, IA & Connor, JR 2023, 'Exosomes are involved in iron transport from human blood–brain barrier endothelial cells and are modified by endothelial cell iron status', Journal of Biological Chemistry, vol. 299, no. 2, 102868. https://doi.org/10.1016/j.jbc.2022.102868
Dhamdhere, MR, Spiegelman, DV, Schneper, L, Erbe, AK, Sondel, PM & Spiegelman, VS 2023, 'Generation of Novel Immunocompetent Mouse Cell Lines to Model Experimental Metastasis of High-Risk Neuroblastoma', Cancers, vol. 15, no. 19, 4693. https://doi.org/10.3390/cancers15194693
Singh, V, Walter, V, Elcheva, I, Imamura Kawasawa, Y & Spiegelman, VS 2023, 'Global role of IGF2BP1 in controlling the expression of Wnt/β-catenin-regulated genes in colorectal cancer cells', Frontiers in Cell and Developmental Biology, vol. 11, 1236356. https://doi.org/10.3389/fcell.2023.1236356
Elcheva, IA, Gowda, CP, Bogush, D, Gornostaeva, S, Fakhardo, A, Sheth, N, Kokolus, KM, Sharma, A, Dovat, S, Uzun, Y, Schell, TD & Spiegelman, VS 2023, 'IGF2BP family of RNA-binding proteins regulate innate and adaptive immune responses in cancer cells and tumor microenvironment', Frontiers in immunology, vol. 14, 1224516. https://doi.org/10.3389/fimmu.2023.1224516
Dhamdhere, MR, Gowda, CP, Singh, V, Liu, Z, Carruthers, N, Grant, C, Sharma, A, Dovat, S, Sundstrom, JM, Wang, HG & Spiegelman, VS 2023, 'IGF2BP1 regulates the cargo of extracellular vesicles and promotes neuroblastoma metastasis', Oncogene, vol. 42, no. 19, pp. 1558-1571. https://doi.org/10.1038/s41388-023-02671-0
2022
Singh, A, Singh, V, Wallis, N, Elimelech, O, Oberman, F, Ramos, A, Yisraeli, J, Spiegelman, V & Sharma, A 2022, 'Development of a Novel IGF2BP1 Inhibitor as Metastasis-Specific Therapeutic Agent', European Journal of Cancer, vol. 174, pp. S104-S105. https://doi.org/10.1016/S0959-8049(22)01078-4
Fakhraldeen, SA, Berry, SM, Beebe, DJ, Roopra, A, Bisbach, CM, Spiegelman, VS, Niemi, NM & Alexander, CM 2022, 'Enhanced immunoprecipitation techniques for the identification of RNA-binding protein partners: IGF2BP1 interactions in mammary epithelial cells', Journal of Biological Chemistry, vol. 298, no. 3, 101649. https://doi.org/10.1016/j.jbc.2022.101649
Betson, N, Hajahmed, M, Gebretsadek, T, Ndebele, K, Ahmad, HA, Tchounwou, PB, Spiegelman, VS & Noubissi, FK 2022, 'Inhibition of insulin-like growth factor 2 mRNA-binding protein 1 sensitizes colorectal cancer cells to chemotherapeutics', FASEB BioAdvances, vol. 4, no. 12, pp. 816-829. https://doi.org/10.1096/fba.2021-00069
Liu, X, Wills, CA, Chen, L, Zhang, J, Zhao, Y, Zhou, M, Sundstrom, JM, Schell, T, Spiegelman, VS, Young, MM & Wang, HG 2022, 'Small extracellular vesicles induce resistance to anti-GD2 immunotherapy unveiling tipifarnib as an adjunct to neuroblastoma immunotherapy', Journal for ImmunoTherapy of Cancer, vol. 10, no. 4, e004399. https://doi.org/10.1136/jitc-2021-004399
Grant, CN, Wills, CA, Liu, X, Spiegelman, VS & Wang, HG 2022, 'Thoracic Neuroblastoma: A Novel Surgical Model for the Study of Extra-adrenal Neuroblastoma', In Vivo, vol. 36, no. 1, pp. 49-56. https://doi.org/10.21873/INVIVO.12675