Pak Kin Wong, PhD - Penn State Cancer Institute
Researcher Profile
Pak Kin Wong, PhD
Professor, Biomedical Engineering
Professor, Department of Surgery
One Health Microbiome Center
Professor, Department of Surgery
One Health Microbiome Center
Scientific Program:Experimental Therapeutics
Recent Publications
2025
Yan, Y, Ahmed, M, Mach, KE, Liao, JC & Wong, PK 2025, 'An Organoid Biosensing Platform for Personalized Prognosis of Bladder Cancer', ACS nano, vol. 19, no. 44, pp. 38305-38317. https://doi.org/10.1021/acsnano.5c09883
Biswas, D, Benson, S, Matunis, A, Gebretsadik, G, Wertz, A, StPierre, BJ, Schacht, N, Yan, Y, Gebremichael, HY, Wong, PK, Baughn, AD & Medina, SH 2025, 'Lead Informed Artificial Intelligence Mining of Antitubercular Host Defense Peptides', Biomacromolecules, vol. 26, no. 5, pp. 3167-3179. https://doi.org/10.1021/acs.biomac.5c00244
Yan, Y, Yang, S, Mach, KE, Chen, G, DeGraff, DJ, Liao, JC & Wong, PK 2025, 'Microbial Product Cocktails for Personalized Cancer Immunotherapy', Nature communications, vol. 16, no. 1, 10625. https://doi.org/10.1038/s41467-025-66238-1
Song, Y, Soto, J, Lin, X, Hoffman, T, Hu, E, Zhu, N, Zarubova, J, Wu, Y, Tian, J, Wong, PK & Li, S 2025, 'Nano-Biosensors for mRNA-Based Cell Sorting Using Intracellular Markers at the Early Stage of Cell Reprogramming', Advanced Functional Materials, vol. 35, no. 1, 2410910. https://doi.org/10.1002/adfm.202410910
Abe, R, Lee, JH, Chin, SM, Ram-Mohan, N, Tjandra, KC, Bobenchik, AM, Mach, KE, Liao, JC, Wong, PK & Yang, S 2025, 'Precision single cell analysis to characterize host dependent antimicrobial response heterogeneity in physiological medium', Lab on a Chip, vol. 25, no. 4, pp. 714-728. https://doi.org/10.1039/d4lc00765d
2024
Lee, JH, Chin, SM, Chan, DC, Liao, JC, Yang, S, Zhang, N & Wong, PK 2024, 'Rapid Microbial Profiling through Multimodal Biosensors for Transversal Analysis', Analytical Chemistry. https://doi.org/10.1021/acs.analchem.4c02449
Li, Y, Zhu, N, Ahmed, M, Urbina, J, Huang, TY & Wong, PK 2024, 'Three-dimensional computer vision for exploring heterogeneity in collective Cancer Invasion', Scientific reports, vol. 14, no. 1, 23560. https://doi.org/10.1038/s41598-024-73688-y
Lee, JH, Chin, SM, Mach, KE, Bobenchik, AM, Liao, JC, Yang, S & Wong, PK 2024, 'Translating microbiota analysis for clinical applications', Nature Reviews Bioengineering, vol. 2, no. 4, 3347, pp. 284-286. https://doi.org/10.1038/s44222-024-00168-3
2023
Mendes, JPP, Zhu, N & Wong, PK 2023, 'A sticky-end probe biosensor for homogeneous detection of transcription factor binding activity', SLAS Technology, vol. 28, no. 5, pp. 345-350. https://doi.org/10.1016/j.slast.2023.05.001
Zhu, N, Ahmed, M, Li, Y, Liao, JC & Wong, PK 2023, 'Long noncoding RNA MALAT1 is dynamically regulated in leader cells during collective cancer invasion', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 27. https://doi.org/10.1073/pnas.2305410120
Li, H, Hsieh, K, Wong, PK, Mach, KE, Liao, JC & Wang, TH 2023, 'Single-cell pathogen diagnostics for combating antibiotic resistance', Nature Reviews Methods Primers, vol. 3, no. 1, 6. https://doi.org/10.1038/s43586-022-00190-y
2022
Lee, JH, van der Linden, C, Diaz, FJ & Wong, PK 2022, 'A reconfigurable microfluidic building block platform for high-throughput nonhormonal contraceptive screening', Lab on a Chip, vol. 22, no. 13, pp. 2531-2539. https://doi.org/10.1039/d2lc00424k
Chen, H, Zhu, N, Biskowitz, R, Liu, J, Deng, C, Wong, PK & Kothapalli, SR 2022, A transparent ultrasound on-chip platform enables high-throughput cell stimulation and simultaneous high-resolution optical imaging. in A Tarnok & JP Houston (eds), Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XX., 119640C, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11964, SPIE, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XX 2022, Virtual, Online, 2/20/22. https://doi.org/10.1117/12.2610058
Meredith, CH, Castonguay, AC, Chiu, YJ, Brooks, AM, Moerman, PG, Torab, P, Wong, PK, Sen, A, Velegol, D & Zarzar, LD 2022, 'Chemical design of self-propelled Janus droplets', Matter, vol. 5, no. 2, pp. 616-633. https://doi.org/10.1016/j.matt.2021.12.014
Tjandra, KC, Ram-Mohan, N, Abe, R, Hashemi, MM, Lee, JH, Chin, SM, Roshardt, MA, Liao, JC, Wong, PK & Yang, S 2022, 'Diagnosis of Bloodstream Infections: An Evolution of Technologies towards Accurate and Rapid Identification and Antibiotic Susceptibility Testing', Antibiotics, vol. 11, no. 4, 511. https://doi.org/10.3390/antibiotics11040511
Vilchez Mercedes, SA, Bocci, F, Ahmed, M, Eder, I, Zhu, N, Levine, H, Onuchic, JN, Jolly, MK & Wong, PK 2022, 'Nrf2 Modulates the Hybrid Epithelial/Mesenchymal Phenotype and Notch Signaling During Collective Cancer Migration', Frontiers in Molecular Biosciences, vol. 9, 807324. https://doi.org/10.3389/fmolb.2022.807324
Vilchez Mercedes, SA, Eder, I, Ahmed, M, Zhu, N & Wong, PK 2022, 'Optimizing locked nucleic acid modification in double-stranded biosensors for live single cell analysis', Analyst, vol. 147, no. 4, pp. 722-733. https://doi.org/10.1039/d1an01802g
Song, Y, Soto, J, Chen, B, Hoffman, T, Zhao, W, Zhu, N, Peng, Q, Liu, L, Ly, C, Wong, PK, Wang, Y, Rowat, AC, Kurdistani, SK & Li, S 2022, 'Transient nuclear deformation primes epigenetic state and promotes cell reprogramming', Nature Materials, vol. 21, no. 10, pp. 1191-1199. https://doi.org/10.1038/s41563-022-01312-3