Patricia McLaughlin, MS, DEd - Penn State Cancer Institute
Researcher Profile
Patricia McLaughlin, MS, DEd
Distinguished Professor, Department of Neuroscience and Experimental Therapeutics
Penn State Neuroscience Institute
Penn State Neuroscience Institute
Scientific Program:Next-Generation Therapies
Recent Publications
2026
Krebs, AK, Diaz, D, Sassani, JW, Zagon, IS & McLaughlin, PJ 2026, 'Mitigation of Oxidative Stress Pathways in the Diabetic Cornea and Lacrimal Glands Contributes to the Rapid Reversal of Diabetic Dry Eye by Naltrexone', Investigative Ophthalmology and Visual Science, vol. 67, no. 2, 23. https://doi.org/10.1167/iovs.67.2.23
2025
Kimchi, ET, Kaifi, JT, Jiang, Y, Li, G, Avella, DM, Gusani, NJ, Schreibman, I, Waybill, P, McLaughlin, P, Zagon, IS, Smith, JP & Staveley-O’Carroll, KF 2025, 'A Phase I Study of the Naturally Occurring Bioactive, Opioid Growth Factor, in Patients with Unresectable Hepatocellular Cancer', Cancer Investigation, vol. 43, no. 3, pp. 224-235. https://doi.org/10.1080/07357907.2025.2484774
Kumari, R, Willing, L & McLaughlin, PJ 2025, 'Diabetes Differentially Alters Glial Cells in Different Brain Regions', Diabetology, vol. 6, no. 3, 16. https://doi.org/10.3390/diabetology6030016
Odom, LB, Thomas, GA, Zachariah, JJ, Zagon, IS & McLaughlin, PJ 2025, 'Exploring the relationships of physical, mental, and emotional symptoms and serum biomarkers of angiogenesis in multiple sclerosis', Multiple Sclerosis Journal - Experimental, Translational and Clinical, vol. 11, no. 2. https://doi.org/10.1177/20552173251329904
Diaz, D, Sassani, JW, Zagon, IS & McLaughlin, PJ 2025, 'Reversal of Diabetic Dry Eye by Topical Opioid Receptor Blockade Follows Dual Pathways', Investigative Ophthalmology and Visual Science, vol. 66, no. 3, 24. https://doi.org/10.1167/iovs.66.3.24
2024
Diaz, D, Sassani, JP, Zagon, IS & McLaughlin, PJ 2024, 'Topical naltrexone increases aquaporin 5 production in the lacrimal gland and restores tear production in diabetic rats', Experimental Biology and Medicine, vol. 249, 10175. https://doi.org/10.3389/ebm.2024.10175
2023
Kumari, R, Kareem, ZY & McLaughlin, PJ 2023, 'Acute Low Dose Naltrexone Increases β-Endorphin and Promotes Neuronal Recovery Following Hypoxia-Ischemic Stroke in Type-2 Diabetic Mice', Neurochemical Research, vol. 48, no. 9, pp. 2835-2846. https://doi.org/10.1007/s11064-023-03938-4
McLaughlin, PJ, West, EA, Grigson, PS & Hobkirk, AL 2023, 'Addiction III: From mouse to man', Brain Research Bulletin, vol. 193, pp. 22-26. https://doi.org/10.1016/j.brainresbull.2022.12.001
Kareem, ZY, McLaughlin, PJ & Kumari, R 2023, 'Opioid growth factor receptor: Anatomical distribution and receptor colocalization in neurons of the adult mouse brain', Neuropeptides, vol. 99, 102325. https://doi.org/10.1016/j.npep.2023.102325
McLaughlin, PJ, Sassani, JW & Zagon, IS 2023, 'Safety study of topical naltrexone therapy for diabetic skin wounds is confirmed in Göttingen mini-pigs', Drug Development Research, vol. 84, no. 6, pp. 1279-1284. https://doi.org/10.1002/ddr.22086
2022
McLaughlin, PJ, Odom, LB, Arnett, PA, Orehek, S, Thomas, GA & Zagon, IS 2022, 'Low-dose naltrexone reduced anxiety in persons with multiple sclerosis during the COVID-19 pandemic', International Immunopharmacology, vol. 113, 109438. https://doi.org/10.1016/j.intimp.2022.109438