Kun-Ming Chen, PhD, MS - Penn State Cancer Institute
Researcher Profile
Kun-Ming Chen, PhD, MS
Associate Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- dibenzo(a,l)pyrene
- Tobacco
- Carcinogens
- Neoplasms
- DNA Damage
- Rubus
- Carcinogenesis
- Mouth
- Smoke
- DNA Adducts
- Proteins
- Environmental Pollutants
Recent Publications
2024
Chen, KM, Sun, YW, Krebs, NM, Reinhart, L, Sun, D, Liao, J, Cook, R, Bond, PE, Mallery, SR & El-Bayoumy, K 2024, 'The Effects of Black Raspberry as a Whole Food–Based Approach on Biomarkers of Oxidative Stress in Buccal Cells and Urine of Smokers', Cancer Prevention Research, vol. 17, no. 4, pp. 157-167. https://doi.org/10.1158/1940-6207.CAPR-23-0153
2023
Manni, A, Sun, YW, Schell, TD, Lutsiv, T, Thompson, H, Chen, KM, Aliaga, C, Zhu, J & El-Bayoumy, K 2023, 'Complementarity between Microbiome and Immunity May Account for the Potentiating Effect of Quercetin on the Antitumor Action of Cyclophosphamide in a Triple-Negative Breast Cancer Model', Pharmaceuticals, vol. 16, no. 10, 1422. https://doi.org/10.3390/ph16101422
Chen, K-M, Sun, Y-W, Hu, J, Balogh, K, Gowda, K, Aliaga, C, Sun, D, Christensen, N, Amin, S & El-Bayoumy, K 2023, 'Gender Difference in DNA Damage Induced by the Environmental Carcinogen Dibenzo[def,p]chrysene Individually and in Combination with Mouse Papillomavirus Infection in the Mouse Oral Cavity', ACS Omega. https://doi.org/10.1021/acsomega.3c09611
2022
Chen, KM, Sun, YW, Sun, D, Gowda, K, Amin, S & El-Bayoumy, K 2022, 'Black Raspberry Extract Enhances Glutathione Conjugation of the Fjord-Region Diol Epoxide Derived from the Tobacco Carcinogen Dibenzo[ def, p]chrysene in Human Oral Cells', Chemical research in toxicology, vol. 35, no. 11, pp. 2152-2159. https://doi.org/10.1021/acs.chemrestox.2c00246
Chen, KM, Sun, YW, Krebs, NM, Sun, D, Krzeminski, J, Reinhart, L, Gowda, K, Amin, S, Mallery, S, Richie, JP & El-Bayoumy, K 2022, 'Detection of DNA adducts derived from the tobacco carcinogens, benzo[a]pyrene and dibenzo[def,p]chrysene in human oral buccal cells', Carcinogenesis, vol. 43, no. 8, pp. 746-753. https://doi.org/10.1093/carcin/bgac058
Sales, AH, Kolbanovskiy, M, Geacintov, NE, Chen, KM, Sun, YW & El-Bayoumy, K 2022, 'Treatment of Human HeLa Cells with Black Raspberry Extracts Enhances the Removal of DNA Lesions by the Nucleotide Excision Repair Mechanism', Antioxidants, vol. 11, no. 11, 2110. https://doi.org/10.3390/antiox11112110
2021
Stairs, DB, Landmesser, ME, Aliaga, C, Chen, KM, Sun, YW & El-Bayoumy, K 2021, 'Black raspberry restores the expression of the tumor suppressor p120ctn in the oral cavity of mice treated with the carcinogen dibenzo[a,l] pyrene diol epoxide', PloS one, vol. 16, no. 11 November, e0259998. https://doi.org/10.1371/journal.pone.0259998
Sun, YW, Chen, KM, Atkins, H, Aliaga, C, Gordon, T, Guttenplan, JB & El-Bayoumy, K 2021, 'Effects of E-Cigarette Aerosols with Varying Levels of Nicotine on Biomarkers of Oxidative Stress and Inflammation in Mice', Chemical research in toxicology, vol. 34, no. 4, pp. 1161-1168. https://doi.org/10.1021/acs.chemrestox.1c00033
Chen, KM, Thompson, H, Vanden-Heuvel, JP, Sun, YW, Trushin, N, Aliaga, C, Gowda, K, Amin, S, Stanley, B, Manni, A & El-Bayoumy, K 2021, 'Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer', Scientific reports, vol. 11, no. 1, 410. https://doi.org/10.1038/s41598-020-79716-x
2020
El-Bayoumy, K, Christensen, ND, Hu, J, Viscidi, R, Stairs, DB, Walter, V, Chen, KM, Sun, YW, Muscat, JE & Richie, JP 2020, 'An integrated approach for preventing oral cavity and oropharyngeal cancers: Two etiologies with distinct and shared mechanisms of carcinogenesis', Cancer Prevention Research, vol. 13, no. 8, pp. 649-660. https://doi.org/10.1158/1940-6207.CAPR-20-0096
Chen, KM, Sun, YW, Kawasawa, YI, Salzberg, AC, Zhu, J, Gowda, K, Aliaga, C, Amin, S, Atkins, H & El-Bayoumy, K 2020, 'Black raspberry inhibits oral tumors in mice treated with the tobacco smoke constituent dibenzo(def,p)chrysene via genetic and epigenetic alterations', Cancer Prevention Research, vol. 13, no. 4, pp. 357-365. https://doi.org/10.1158/1940-6207.CAPR-19-0496
Christensen, ND, Chen, KM, Hu, J, Stairs, DB, Sun, YW, Aliaga, C, Balogh, KK, Atkins, H, Shearer, D, Li, J, Brendle, SA, Gowda, K, Amin, S, Walter, V, Viscidi, R & El-Bayoumy, K 2021, 'The environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections', Chemico-Biological Interactions, vol. 333, 109321. https://doi.org/10.1016/j.cbi.2020.109321