John Flanagan, PhD - Penn State Cancer Institute
Researcher Profile
John Flanagan, PhD
Professor, Department of Molecular and Precision Medicine
Scientific Program:Next-Generation Therapies
Recent Publications
2025
Bianchini, EN, Pérez-Segura, C, Liu, H, Luckenbaugh, L, Flanagan, J, Cai, Y, Shanklin, J, Zlotnick, A, Hadden-Perilla, JA, Hu, J & C.-Y. Wang, J 2026, 'Cryo-EM structures of HBV capsids from human cells at near-atomic resolution', Structure, vol. 34, no. 2, pp. 240-253.e5. https://doi.org/10.1016/j.str.2025.11.005
2024
Kumar, R, Maldonado, RK, Christensen, N, Bewley, MC, Flanagan, J, Buchkovich, N & Parent, L 2024, 'ESCRT Protein VPS4A Is Required for the Formation of Replication Centers and Replication of Human Coronavirus 229E (HCoV-229E)', COVID, vol. 4, no. 9, pp. 1338-1354. https://doi.org/10.3390/covid4090095
Ye, Y, Liang, X, Wang, G, Bewley, MC, Hamamoto, K, Liu, X, Flanagan, J, Wang, H-G, Takahashi, Y & Tian, F 2024, 'Identification of membrane curvature sensing motifs essential for VPS37A phagophore recruitment and autophagosome closure', Communications Biology, vol. 7, no. 1, 334. https://doi.org/10.1038/s42003-024-06026-7
2023
Palsa, K, Connor, JR, Flanagan, J & Hines, EA 2023, 'H-ferritin in sows' colostrum- and milk-derived extracellular vesicles: a novel iron delivery concept', Journal of animal science, vol. 101, skad013. https://doi.org/10.1093/jas/skad013
Monette, A, Niu, M, Maldonado, RK, Chang, J, Lambert, GS, Flanagan, JM, Cochrane, A, Parent, LJ & Mouland, AJ 2023, 'Influence of HIV-1 Genomic RNA on the Formation of Gag Biomolecular Condensates', Journal of Molecular Biology, vol. 435, no. 16, 168190. https://doi.org/10.1016/j.jmb.2023.168190
Ye, Y, Tyndall, ER, Bui, V, Bewley, MC, Wang, G, Hong, X, Shen, Y, Flanagan, JM, Wang, HG & Tian, F 2023, 'Multifaceted membrane interactions of human Atg3 promote LC3-phosphatidylethanolamine conjugation during autophagy', Nature communications, vol. 14, no. 1, 5503. https://doi.org/10.1038/s41467-023-41243-4
Carkaci-Salli, N, Bewley, MC, Tekin, I, Flanagan, JM & Vrana, KE 2023, 'The A328 V/E (rs2887147) polymorphisms in human tryptophan hydroxylase 2 compromise enzyme activity', Biochemistry and Biophysics Reports, vol. 35, 101527. https://doi.org/10.1016/j.bbrep.2023.101527
Kaddis Maldonado, R, Lambert, GS, Rice, BL, Sudol, M, Flanagan, JM & Parent, LJ 2023, 'The Rous sarcoma virus Gag Polyprotein Forms Biomolecular Condensates Driven by Intrinsically-disordered Regions', Journal of Molecular Biology, vol. 435, no. 16, 168182. https://doi.org/10.1016/j.jmb.2023.168182
Ye, Y, Bewley, MC, Wang, HG, Tian, F & Flanagan, JM 2024, 'What’s in an E3: role of highly curved membranes in facilitating LC3–phosphatidylethanolamine conjugation during autophagy', Autophagy, vol. 20, no. 3, pp. 709-711. https://doi.org/10.1080/15548627.2023.2288527