George-Lucian Moldovan, PhD - Penn State Cancer Institute
Researcher Profile
George-Lucian Moldovan, PhD
Professor, Department of Molecular and Precision Medicine
Scientific Program:Next-Generation Therapies
Recent Publications
2025
Dhoonmoon, A, Ambrose, JR, Garg, S, Lascarez-Espana, C, Rebok, A, Spratt, T, Moldovan, GL & Nicolae, CM 2025, 'Translesion-synthesis-mediated bypass of DNA lesions occurs predominantly behind replication forks restarted by PrimPol', Cell Reports, vol. 44, no. 3, 115360. https://doi.org/10.1016/j.celrep.2025.115360
2024
Straka, J, Khatib, JB, Pale, L, Nicolae, CM & Moldovan, GL 2024, 'CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation', Nucleic acids research, vol. 52, no. 22, pp. 13865-13880. https://doi.org/10.1093/nar/gkae1068
Pale, LM, Khatib, JB, Nusawardhana, A, Straka, J, Nicolae, CM & Moldovan, GL 2024, 'CRISPR knockout genome-wide screens identify the HELQ-RAD52 axis in regulating the repair of cisplatin-induced single-stranded DNA gaps', Nucleic acids research, vol. 52, no. 22, pp. 13832-13848. https://doi.org/10.1093/nar/gkae998
Hale, A & Moldovan, GL 2024, 'Novel insights into the role of bisphenol A (BPA) in genomic instability', NAR Cancer, vol. 6, no. 3, zcae038. https://doi.org/10.1093/narcan/zcae038
Khatib, JB, Dhoonmoon, A, Moldovan, GL & Nicolae, CM 2024, 'PARP10 promotes the repair of nascent strand DNA gaps through RAD18 mediated translesion synthesis', Nature communications, vol. 15, no. 1, 6197. https://doi.org/10.1038/s41467-024-50429-3
Nusawardhana, A, Pale, LM, Nicolae, CM & Moldovan, GL 2024, 'USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during replication stress', Nucleic acids research, vol. 52, no. 5, pp. 2340-2354. https://doi.org/10.1093/nar/gkad1237
2023
Wang, YC, Kelso, AA, Karamafrooz, A, Chen, YH, Chen, WK, Cheng, CT, Qi, Y, Gu, L, Malkas, L, Taglialatela, A, Kung, HJ, Moldovan, GL, Ciccia, A, Stark, JM & Ann, DK 2023, 'Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination', Cell Reports, vol. 42, no. 4, 112296. https://doi.org/10.1016/j.celrep.2023.112296
Leung, W, Baxley, RM, Traband, E, Chang, YC, Rogers, CB, Wang, L, Durrett, W, Bromley, KS, Fiedorowicz, L, Thakar, T, Tella, A, Sobeck, A, Hendrickson, EA, Moldovan, GL, Shima, N & Bielinsky, AK 2023, 'FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination', Cell Reports, vol. 42, no. 12, 113523. https://doi.org/10.1016/j.celrep.2023.113523
Hale, A, Dhoonmoon, A, Straka, J, Nicolae, CM & Moldovan, GL 2023, 'Multi-step processing of replication stress-derived nascent strand DNA gaps by MRE11 and EXO1 nucleases', Nature communications, vol. 14, no. 1, 6265. https://doi.org/10.1038/s41467-023-42011-0
Khatib, JB, Nicolae, CM & Moldovan, GL 2024, 'Role of Translesion DNA Synthesis in the Metabolism of Replication-associated Nascent Strand Gaps', Journal of Molecular Biology, vol. 436, no. 1, 168275. https://doi.org/10.1016/j.jmb.2023.168275
2022
Khatib, JB, Schleicher, EM, Jackson, LM, Dhoonmoon, A, Moldovan, GL & Nicolae, CM 2022, 'Complementary CRISPR genome-wide genetic screens in PARP10-knockout and overexpressing cells identify synthetic interactions for PARP10-mediated cellular survival', Oncotarget, vol. 13, no. 1, pp. 1078-1091. https://doi.org/10.18632/oncotarget.28277
Thakar, T, Dhoonmoon, A, Straka, J, Schleicher, EM, Nicolae, CM & Moldovan, GL 2022, 'Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling', Nature communications, vol. 13, no. 1, 5323. https://doi.org/10.1038/s41467-022-33028-y
Jackson, LM & Moldovan, GL 2022, 'Mechanisms of PARP1 inhibitor resistance and their implications for cancer treatment', NAR Cancer, vol. 4, no. 4, zcac042. https://doi.org/10.1093/narcan/zcac042
Abu-Libdeh, B, Jhujh, SS, Dhar, S, Sommers, JA, Datta, A, Longo, GMC, Grange, LJ, Reynolds, JJ, Cooke, SL, McNee, GS, Hollingworth, R, Woodward, BL, Ganesh, AN, Smerdon, SJ, Nicolae, CM, Durlacher-Betzer, K, Molho-Pessach, V, Abu-Libdeh, A, Meiner, V, Moldovan, GL, Roukos, V, Harel, T, Brosh, RM & Stewart, GS 2022, 'RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1', Journal of Clinical Investigation, vol. 132, no. 5, e147301. https://doi.org/10.1172/JCI147301
Dhoonmoon, A, Nicolae, CM & Moldovan, GL 2022, 'The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1', Nature communications, vol. 13, no. 1, 5063. https://doi.org/10.1038/s41467-022-32756-5
Schleicher, EM, Dhoonmoon, A, Jackson, LM, Khatib, JB, Nicolae, CM & Moldovan, GL 2022, 'The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells', Oncogenesis, vol. 11, no. 1, 33. https://doi.org/10.1038/s41389-022-00410-w
Hirschler-Laszkiewicz, I, Festa, F, Huang, S, Moldovan, GL, Nicolae, C, Dhoonmoon, A, Bao, L, Keefer, K, Chen, SJ, Wang, HG, Cheung, JY & Miller, BA 2022, 'The human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1', Scientific reports, vol. 12, no. 1, 6311. https://doi.org/10.1038/s41598-022-10385-8
2021
Lüscher, B, Ahel, I, Altmeyer, M, Ashworth, A, Bai, P, Chang, P, Cohen, M, Corda, D, Dantzer, F, Daugherty, MD, Dawson, TM, Dawson, VL, Deindl, S, Fehr, AR, Feijs, KLH, Filippov, DV, Gagné, JP, Grimaldi, G, Guettler, S, Hoch, NC, Hottiger, MO, Korn, P, Kraus, WL, Ladurner, A, Lehtiö, L, Leung, AKL, Lord, CJ, Mangerich, A, Matic, I, Matthews, J, Moldovan, GL, Moss, J, Natoli, G, Nielsen, ML, Niepel, M, Nolte, F, Pascal, J, Paschal, BM, Pawłowski, K, Poirier, GG, Smith, S, Timinszky, G, Wang, ZQ, Yélamos, J, Yu, X, Zaja, R & Ziegler, M 2022, 'ADP-ribosyltransferases, an update on function and nomenclature', FEBS Journal, vol. 289, no. 23, pp. 7399-7410. https://doi.org/10.1111/febs.16142
Weissenrieder, JS, Reed, JL, Moldovan, GL, Johnson, MT, Trebak, M, Neighbors, JD, Mailman, RB & Hohl, RJ 2021, 'Antipsychotic drugs elicit cytotoxicity in glioblastoma multiforme in a calcium-dependent, non-D2 receptor-dependent, manner', Pharmacology Research and Perspectives, vol. 9, no. 3, e00689. https://doi.org/10.1002/prp2.689
Schleicher, EM & Moldovan, GL 2022, 'CRISPR screens guide the way for PARP and ATR inhibitor biomarker discovery', FEBS Journal, vol. 289, no. 24, pp. 7854-7868. https://doi.org/10.1111/febs.16217
Jackson, LM, Dhoonmoon, A, Hale, A, Dennis, KA, Schleicher, EM, Nicolae, CM & Moldovan, GL 2021, 'Loss of MED12 activates the TGFβ pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells', Nucleic acids research, vol. 49, no. 22, pp. 12855-12869. https://doi.org/10.1093/nar/gkab1184
O’Connor, MJ, Thakar, T, Nicolae, CM & Moldovan, GL 2021, 'PARP14 regulates cyclin D1 expression to promote cell-cycle progression', Oncogene, vol. 40, no. 30, pp. 4872-4883. https://doi.org/10.1038/s41388-021-01881-8
Thakar, T & Moldovan, GL 2021, 'The emerging determinants of replication fork stability', Nucleic acids research, vol. 49, no. 13, pp. 7224-7238. https://doi.org/10.1093/nar/gkab344
Datta, A, Biswas, K, Sommers, JA, Thompson, H, Awate, S, Nicolae, CM, Thakar, T, Moldovan, GL, Shoemaker, RH, Sharan, SK & Brosh, RM 2021, 'WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells', Nature communications, vol. 12, no. 1, 6561. https://doi.org/10.1038/s41467-021-26811-w