Jiafen Hu, MSc, PhD - Penn State Cancer Institute
Researcher Profile
Jiafen Hu, MSc, PhD
Assistant Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Division of Experimental Pathology
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- Rabbits
- Cottontail rabbit papillomavirus
- Papillomavirus Infections
- Immunity
- Infections
- Neoplasms
- Papilloma
- Skin
- DNA
- Vaccination
- Genome
- Epitopes
Recent Publications
2024
Kozak, M & Hu, J 2024, 'DNA Vaccines: Their Formulations, Engineering and Delivery', Vaccines, vol. 12, no. 1, 71. https://doi.org/10.3390/vaccines12010071
Momenilandi, M, Lévy, R, Sobrino, S, Li, J, Lagresle-Peyrou, C, Esmaeilzadeh, H, Fayand, A, Le Floc'h, C, Guérin, A, Mina, ED, Shearer, D, Delmonte, OM, Yatim, A, Mulder, K, Mancini, M, Rinchai, D, Denis, A, Neehus, AL, Balogh, K, Brendle, S, Rokni-Zadeh, H, Changi-Ashtiani, M, Seeleuthner, Y, Deswarte, C, Bessot, B, Cremades, C, Materna, M, Cederholm, A, Ogishi, M, Philippot, Q, Beganovic, O, Ackermann, M, Wuyts, M, Khan, T, Fouéré, S, Herms, F, Chanal, J, Palterer, B, Bruneau, J, Molina, TJ, Leclerc-Mercier, S, Prétet, JL, Youssefian, L, Vahidnezhad, H, Parvaneh, N, Claeys, KG, Schrijvers, R, Luka, M, Pérot, P, Fourgeaud, J, Nourrisson, C, Poirier, P, Jouanguy, E, Boisson-Dupuis, S, Bustamante, J, Notarangelo, LD, Christensen, N, Landegren, N, Abel, L, Marr, N, Six, E, Langlais, D, Waterboer, T, Ginhoux, F, Ma, CS, Tangye, SG, Meyts, I, Lachmann, N, Hu, J, Shahrooei, M, Bossuyt, X, Casanova, JL & Béziat, V 2024, 'FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice', Cell, vol. 187, no. 11, pp. 2817-2837.e31. https://doi.org/10.1016/j.cell.2024.04.009
Fobian, SF, Mei, X, Crezee, J, Snoek, BC, Steenbergen, RDM, Hu, J, ten Hagen, TLM, Vermeulen, L, Stalpers, LJA & Oei, AL 2024, 'Increased human papillomavirus viral load is correlated to higher severity of cervical disease and poorer clinical outcome: A systematic review', Journal of Medical Virology, vol. 96, no. 6, e29741. https://doi.org/10.1002/jmv.29741
2023
Chen, K-M, Sun, Y-W, Hu, J, Balogh, K, Gowda, K, Aliaga, C, Sun, D, Christensen, N, Amin, S & El-Bayoumy, K 2023, 'Gender Difference in DNA Damage Induced by the Environmental Carcinogen Dibenzo[def,p]chrysene Individually and in Combination with Mouse Papillomavirus Infection in the Mouse Oral Cavity', ACS Omega. https://doi.org/10.1021/acsomega.3c09611
Brendle, SA, Li, JJ, Walter, V, Schell, T, Kozak, M, Balogh, KK, Lu, S, Christensen, ND, Zhu, Y, El-Bayoumy, K & Hu, J 2023, 'Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model', Pathogens, vol. 12, no. 12, 1452. https://doi.org/10.3390/pathogens12121452
Kozak, M & Hu, J 2023, 'The Integrated Consideration of Vaccine Platforms, Adjuvants, and Delivery Routes for Successful Vaccine Development', Vaccines, vol. 11, no. 3, 695. https://doi.org/10.3390/vaccines11030695
2022
Hu, J, Brendle, SA, Li, JJ, Walter, V, Cladel, NM, Cooper, T, Shearer, DA, Balogh, KK & Christensen, ND 2022, 'Depo Medroxyprogesterone (DMPA) Promotes Papillomavirus Infections but Does Not Accelerate Disease Progression in the Anogenital Tract of a Mouse Model', Viruses, vol. 14, no. 5, 980. https://doi.org/10.3390/v14050980
Cladel, NM, Xu, J, Peng, X, Jiang, P, Christensen, ND, Zheng, ZM & Hu, J 2022, 'Modeling HPV-Associated Disease and Cancer Using the Cottontail Rabbit Papillomavirus', Viruses, vol. 14, no. 9, 1964. https://doi.org/10.3390/v14091964
Brendle, SA, Li, J, Cladel, NM, Balogh, KK, Booth, J, Shearer, DA, Walter, V, Lu, S, Christensen, ND, Covington, D, DeBroff, J, Milici, J, Zhu, Y, Viscidi, R & Hu, J 2022, 'Passive Immunization with a Single Monoclonal Neutralizing Antibody Protects against Cutaneous and Mucosal Mouse Papillomavirus Infections', Journal of virology, vol. 96, no. 16. https://doi.org/10.1128/jvi.00703-22
Olczak, P, Matsui, K, Wong, M, Alvarez, J, Lambert, P, Christensen, ND, Hu, J, Huber, B, Kirnbauer, R, Wang, JW & Roden, RBS 2022, 'RG2-VLP: a Vaccine Designed to Broadly Protect against Anogenital and Skin Human Papillomaviruses Causing Human Cancer', Journal of virology, vol. 96, no. 13. https://doi.org/10.1128/jvi.00566-22
2021
Brendle, S, Cladel, N, Balogh, K, Alam, S, Christensen, N, Meyers, C & Hu, J 2021, 'A comparative study on delivery of externally attached dna by papillomavirus vlps and pseudoviruses', Vaccines, vol. 9, no. 12, 1501. https://doi.org/10.3390/vaccines9121501
Hartmann, SR, Goetschius, DJ, Hu, J, Graff, JJ, Bator, CM, Christensen, ND & Hafenstein, SL 2021, 'Cryo em analysis reveals inherent flexibility of authentic murine papillomavirus capsids', Viruses, vol. 13, no. 10, 2023. https://doi.org/10.3390/v13102023
Xu, J, Zhang, J, Yang, D, Song, J, Pallas, B, Zhang, C, Hu, J, Peng, X, Christensen, ND, Han, R & Chen, YE 2021, 'Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research', Frontiers in Genetics, vol. 12, 642444. https://doi.org/10.3389/fgene.2021.642444
Béziat, V, Rapaport, F, Hu, J, Titeux, M, Bonnet des Claustres, M, Bourgey, M, Griffin, H, Bandet, É, Ma, CS, Sherkat, R, Rokni-Zadeh, H, Louis, DM, Changi-Ashtiani, M, Delmonte, OM, Fukushima, T, Habib, T, Guennoun, A, Khan, T, Bender, N, Rahman, M, About, F, Yang, R, Rao, G, Rouzaud, C, Li, J, Shearer, D, Balogh, K, Al Ali, F, Ata, M, Dabiri, S, Momenilandi, M, Nammour, J, Alyanakian, MA, Leruez-Ville, M, Guenat, D, Materna, M, Marcot, L, Vladikine, N, Soret, C, Vahidnezhad, H, Youssefian, L, Saeidian, AH, Uitto, J, Catherinot, É, Navabi, SS, Zarhrate, M, Woodley, DT, Jeljeli, M, Abraham, T, Belkaya, S, Lorenzo, L, Rosain, J, Bayat, M, Lanternier, F, Lortholary, O, Zakavi, F, Gros, P, Orth, G, Abel, L, Prétet, JL, Fraitag, S, Jouanguy, E, Davis, MM, Tangye, SG, Notarangelo, LD, Marr, N, Waterboer, T, Langlais, D, Doorbar, J, Hovnanian, A, Christensen, N, Bossuyt, X, Shahrooei, M & Casanova, JL 2021, 'Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy', Cell, vol. 184, no. 14, pp. 3812-3828.e30. https://doi.org/10.1016/j.cell.2021.06.004
Brendle, S, Li, JJ, Cladel, NM, Shearer, DA, Budgeon, LR, Balogh, KK, Atkins, H, Costa-Fujishima, M, Lopez, P, Christensen, ND, Doorbar, J, Murooka, TT & Hu, J 2021, 'Mouse papillomavirus l1 and l2 are dispensable for viral infection and persistence at both cutaneous and mucosal tissues', Viruses, vol. 13, no. 9, 1824. https://doi.org/10.3390/v13091824
2020
El-Bayoumy, K, Christensen, ND, Hu, J, Viscidi, R, Stairs, DB, Walter, V, Chen, KM, Sun, YW, Muscat, JE & Richie, JP 2020, 'An integrated approach for preventing oral cavity and oropharyngeal cancers: Two etiologies with distinct and shared mechanisms of carcinogenesis', Cancer Prevention Research, vol. 13, no. 8, pp. 649-660. https://doi.org/10.1158/1940-6207.CAPR-20-0096
Osborne, AJ, Atkins, HM, Balogh, KK, Brendle, SA, Shearer, DA, Hu, J, Sample, CE & Christensen, ND 2020, 'Antibody-mediated immune subset depletion modulates the immune response in a rabbit (Oryctolagus cuniculus) model of Epstein-Barr virus infection', Comparative Medicine, vol. 70, no. 5, pp. 312-322. https://doi.org/10.30802/AALAS-CM-20-000019
Christensen, ND, Chen, KM, Hu, J, Stairs, DB, Sun, YW, Aliaga, C, Balogh, KK, Atkins, H, Shearer, D, Li, J, Brendle, SA, Gowda, K, Amin, S, Walter, V, Viscidi, R & El-Bayoumy, K 2021, 'The environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections', Chemico-Biological Interactions, vol. 333, 109321. https://doi.org/10.1016/j.cbi.2020.109321