Dhimant Desai, PhD - Penn State Cancer Institute
Researcher Profile
Dhimant Desai, PhD
Professor, Department of Molecular and Precision Medicine
Penn State Neuroscience Institute
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Penn State Neuroscience Institute
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Scientific Program:Next-Generation Therapies
Recent Publications
2025
Ding, Y, He, B, Bogush, D, Schramm, J, Singh, C, Dovat, K, Randazzo, J, Tukaramrao, D, Hengst, J, Annageldiyev, C, Kudva, A, Desai, D, Sharma, A, Spiegelman, VS, Huang, S, Viet, CT, Dorsam, G, Saulnier Scholler, G, Broach, J, Yue, F & Dovat, S 2025, 'Critical roles of IKAROS and HDAC1 in regulation of heterochromatin and tumor suppression in T-cell acute lymphoblastic leukemia', Leukemia, vol. 39, no. 8, pp. 2010-2020. https://doi.org/10.1038/s41375-025-02651-1
El-Bayoumy, K, Christensen, N, Broach, J, Meyers, C, Stairs, D, Machtay, M, Hu, J, Bitzer, ZT, Schell, TD, Chen, K-M, Sun, Y-W, Desai, D, Walter, V & Zhu, J 2025, 'Current challenges and potential opportunities for interception and prevention of head and neck cancer', Carcinogenesis, vol. 46, no. 2, bgaf025. https://doi.org/10.1093/carcin/bgaf025
Janakiram, NB, Mohammed, A, Ravillah, D, Choi, CI, Zhang, Y, Desai, D, Amin, S & Rao, CV 2025, 'Erratum: Corrigendum] Chemopreventive effects of PBI‑Se, a selenium‑containing analog of PBIT, on AOM‑induced aberrant crypt foci in F344 rats (Oncology reports (2013) 30 2 PII: 44 DOI: 10.3892/or.2013.2483.)', Oncology reports, vol. 53, no. 4. https://doi.org/10.3892/or.2025.8877
Schell, TD, Bitzer, ZT, Chen, KM, Aliaga, C, Sun, YW, Desai, D, Lanza, M, Hu, J, Christensen, N & El-Bayoumy, K 2025, 'The effects of Co-exposure of tobacco smoke with Dibenzo[a,l]pyrene diol epoxide on molecular targets and immune cells in the mouse oral cavity', Chemico-Biological Interactions, vol. 420, 111694. https://doi.org/10.1016/j.cbi.2025.111694
2024
Rimal, B, Collins, SL, Tanes, CE, Rocha, ER, Granda, MA, Solanki, S, Hoque, NJ, Gentry, EC, Koo, I, Reilly, ER, Hao, F, Paudel, D, Singh, V, Yan, T, Kim, MS, Bittinger, K, Zackular, JP, Krausz, KW, Desai, D, Amin, S, Coleman, JP, Shah, YM, Bisanz, JE, Gonzalez, FJ, Vanden Heuvel, JP, Wu, GD, Zemel, BS, Dorrestein, PC, Weinert, EE & Patterson, AD 2024, 'Bile salt hydrolase catalyses formation of amine-conjugated bile acids', Nature, vol. 626, no. 8000, pp. 859-863. https://doi.org/10.1038/s41586-023-06990-w
Al-Odat, OS, Nelson, E, Budak-Alpdogan, T, Jonnalagadda, SC, Desai, D & Pandey, MK 2024, 'Discovering Potential in Non-Cancer Medications: A Promising Breakthrough for Multiple Myeloma Patients', Cancers, vol. 16, no. 13, 2381. https://doi.org/10.3390/cancers16132381
Sepulveda, DE, Vrana, K, Kellogg, J, Bisanz, J, Desai, D, Graziane, NM & Raup-Konsavage, WM 2024, 'The Potential of Cannabichromene (CBC) as a Therapeutic Agent', Journal of Pharmacology and Experimental Therapeutics, vol. 391, no. 2, pp. 206-213. https://doi.org/10.1124/jpet.124.002166
Mohanty, I, Mannochio-Russo, H, Schweer, JV, El Abiead, Y, Bittremieux, W, Xing, S, Schmid, R, Zuffa, S, Vasquez, F, Muti, VB, Zemlin, J, Tovar-Herrera, OE, Moraïs, S, Desai, D, Amin, S, Koo, I, Turck, CW, Mizrahi, I, Kris-Etherton, PM, Petersen, K, Fleming, JA, Huan, T, Patterson, AD, Siegel, D, Hagey, LR, Wang, M, Aron, AT & Dorrestein, PC 2024, 'The underappreciated diversity of bile acid modifications', Cell, vol. 187, no. 7, pp. 1801-1818.e20. https://doi.org/10.1016/j.cell.2024.02.019
2023
Zhou, X, Chakraborty, D, Murray, IA, Coslo, D, Kehs, Z, Vijay, A, Ton, C, Desai, D, Amin, SG, Patterson, AD & Perdew, GH 2023, 'Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming', Laboratory Investigation, vol. 103, no. 2, 100012. https://doi.org/10.1016/j.labinv.2022.100012
Kale, VP, Hengst, JA, Sharma, AK, Golla, U, Dovat, S, Amin, SG, Yun, JK & Desai, DH 2023, 'Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases', Pharmaceuticals, vol. 16, no. 8, 1060. https://doi.org/10.3390/ph16081060
Dong, F, Murray, IA, Annalora, A, Coslo, DM, Desai, D, Gowda, K, Yang, J, Wang, D, Koo, I, Hao, F, Amin, SG, Patterson, AD, Marcus, C & Perdew, GH 2023, 'Complex chemical signals dictate Ah receptor activation through the gut-lung axis', FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 37, no. 7, pp. e23010. https://doi.org/10.1096/fj.202300703R
Garg, A, Desai, D, Bhalla, A, Thakur, S, Rastogi, P & Kaushal, N 2023, 'SelSA-1, a novel HDAC inhibitor demonstrates enhanced chemotherapeutic potential by redox modulation', Scientific reports, vol. 13, no. 1, 9301. https://doi.org/10.1038/s41598-023-36555-w
Bogush, D, Schramm, J, Ding, Y, He, B, Singh, C, Sharma, A, Tukaramrao, DB, Iyer, S, Desai, D, Nalesnik, G, Hengst, J, Bhalodia, R, Gowda, C & Dovat, S 2023, 'Signaling pathways and regulation of gene expression in hematopoietic cells', Advances in Biological Regulation, vol. 88, 100942. https://doi.org/10.1016/j.jbior.2022.100942
2022
Raup-Konsavage, WM, Sepulveda, DE, Morris, DP, Amin, S, Vrana, KE, Graziane, NM & Desai, D 2022, 'Efficient Synthesis for Altering Side Chain Length on Cannabinoid Molecules and Their Effects in Chemotherapy and Chemotherapeutic Induced Neuropathic Pain', Biomolecules, vol. 12, no. 12, 1869. https://doi.org/10.3390/biom12121869
Jiang, J, Ma, Y, Liu, Y, Lu, D, Gao, X, Krausz, KW, Desai, D, Amin, SG, Patterson, AD, Gonzalez, FJ & Xie, C 2022, 'Glycine-β-muricholic acid antagonizes the intestinal farnesoid X receptor–ceramide axis and ameliorates NASH in mice', Hepatology Communications, vol. 6, no. 12, pp. 3363-3378. https://doi.org/10.1002/hep4.2099
DiPasquale, M, Deering, TG, Desai, D, Sharma, AK, Amin, S, Fox, TE, Kester, M, Katsaras, J, Marquardt, D & Heberle, FA 2022, 'Influence of ceramide on lipid domain stability studied with small-angle neutron scattering: The role of acyl chain length and unsaturation', Chemistry and Physics of Lipids, vol. 245, 105205. https://doi.org/10.1016/j.chemphyslip.2022.105205
Kaur, R, Desai, D, Amin, S, Raza, K, Bhalla, A, Yadav, P & Kaushal, N 2023, 'Selenocoxib-3, a novel anti-inflammatory therapeutic effectively resolves colitis', Molecular and Cellular Biochemistry, vol. 478, no. 3, pp. 621-636. https://doi.org/10.1007/s11010-022-04532-y
Dinavahi, SS, Chen, YC, Gowda, R, Dhanyamraju, PK, Punnath, K, Desai, D, Berg, A, Kimball, SR, Amin, S, Yang, JM & Robertson, GP 2022, 'Targeting Protein Translation in Melanoma by Inhibiting EEF-2 Kinase Regulates Cholesterol Metabolism though SREBP2 to Inhibit Tumour Development', International journal of molecular sciences, vol. 23, no. 7, 3481. https://doi.org/10.3390/ijms23073481
Ehudin, MA, Golla, U, Trivedi, D, Potlakayala, SD, Rudrabhatla, SV, Desai, D, Dovat, S, Claxton, D & Sharma, A 2022, 'Therapeutic Benefits of Selenium in Hematological Malignancies', International journal of molecular sciences, vol. 23, no. 14, 7972. https://doi.org/10.3390/ijms23147972