Researcher Profile
Researcher Profile
Cameron Varano
Assistant Research Professor, Biomedical Engineering
Scientific Program:Next-Generation Therapies
Research Interests
- Proteins
- Electron Microscopy
- Neoplasms
- Breast Neoplasms
- Cryoelectron Microscopy
- Therapeutics
- silicon nitride
- Fusobacterium nucleatum
- Phospholipases
- Fusobacterium
- Protein Aggregates
- Rotavirus
Recent Publications
2020
Dukes, M, Kelly, D & Varano, C 2020, 'Liquid cell TEM imaging techniques and optimization for biological samples', Microscopy and Microanalysis. https://doi.org/10.1017/S1431927620023788
2019
Hauser, M, Dearnaley, WJ, Varano, AC, Casasanta, M, McDonald, SM & Kelly, DF 2019, 'Cryo-EM Reveals Architectural Diversity in Active Rotavirus Particles', Computational and Structural Biotechnology Journal, vol. 17, pp. 1178-1183. https://doi.org/10.1016/j.csbj.2019.07.019
Alden, NA, Varano, AC, Dearnaley, WJ, Solares, MJ, Luqiu, WY, Liang, Y, Sheng, Z, McDonald, SM, Damiano, J, McConnell, J, Dukes, MJ & Kelly, DF 2019, 'Cryo-EM-On-a-Chip: Custom-Designed Substrates for the 3D Analysis of Macromolecules', Small, vol. 15, no. 21, 1900918. https://doi.org/10.1002/smll.201900918
Dearnaley, WJ, Schleupner, B, Varano, AC, Alden, NA, Gonzalez, F, Casasanta, MA, Scharf, BE, Dukes, MJ & Kelly, DF 2019, 'Liquid-Cell Electron Tomography of Biological Systems', Nano letters, vol. 19, no. 10, pp. 6734-6741. https://doi.org/10.1021/acs.nanolett.9b01309
2018
Gilmore, BL, Varano, AC, Dearnaley, W, Liang, Y, Marcinkowski, BC, Dukes, MJ & Kelly, DF 2018, Preparation of tunable microchips to visualize native protein complexes for single-particle electron microscopy. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1764, Humana Press Inc., pp. 45-58. https://doi.org/10.1007/978-1-4939-7759-8_3
2017
Casasanta, MA, Yoo, CC, Smith, HB, Duncan, AJ, Cochrane, K, Varano, AC, Allen-Vercoe, E & Slade, DJ 2017, 'A chemical and biological toolbox for Type Vd secretion: Characterization of the phospholipase A1 autotransporter FplA from Fusobacterium nucleatum', Journal of Biological Chemistry, vol. 292, no. 49, pp. 20240-20254. https://doi.org/10.1074/jbc.M117.819144
Gilmore, BL, Liang, Y, Winton, CE, Patel, K, Karageorge, V, Varano, AC, Dearnaley, W, Sheng, Z & Kelly, DF 2017, 'Molecular Analysis of BRCA1 in Human Breast Cancer Cells under Oxidative Stress', Scientific reports, vol. 7, 43435. https://doi.org/10.1038/srep43435
Cameron Varano, A, Harafuji, N, Dearnaley, W, Guay-Woodford, L & Kelly, DF 2017, Preparation of disease-related protein assemblies for single particle electron microscopy. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1647, Humana Press Inc., pp. 185-196. https://doi.org/10.1007/978-1-4939-7201-2_12
DiMemmo, LM, Cameron Varano, A, Haulenbeek, J, Liang, Y, Patel, K, Dukes, MJ, Zheng, S, Hubert, M, Piccoli, SP & Kelly, DF 2017, 'Real-time observation of protein aggregates in pharmaceutical formulations using liquid cell electron microscopy', Lab on a Chip, vol. 17, no. 2, pp. 315-322. https://doi.org/10.1039/C6LC01160H
Liang, Y, Dearnaley, WJ, Cameron Varano, A, Winton, CE, Gilmore, BL, Alden, NA, Sheng, Z & Kelly, DF 2017, 'Structural analysis of BRCA1 reveals modification hotspot', Science Advances, vol. 3, no. 9, 1701386. https://doi.org/10.1126/sciadv.1701386