Researcher Profile

Researcher Profile

Mark Hedglin

Mark Hedglin

Associate Research Professor, Chemistry
Scientific Program:Mechanisms of Carcinogenesis
muh218@psu.edu

Research Interests

  • DNA
  • Proliferating Cell Nuclear Antigen
  • 3-methyladenine-DNA glycosylase
  • Proteins
  • DNA Damage
  • Single-Stranded DNA
  • Holoenzymes
  • Replication Protein A
  • DNA-Directed DNA Polymerase
  • DNA Repair
  • Facilitated Diffusion
  • DNA Glycosylases

Recent Publications

2019

Hedglin, M, Aitha, M, Pedley, A & Benkovic, SJ 2019, 'Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen' Journal of Biological Chemistry, vol. 294, no. 13, pp. 5157-5168. https://doi.org/10.1074/jbc.RA118.005297

2017

Hedglin, M & Benkovic, S 2017, 'Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours around the Same Obstacle', Chemical Reviews, vol. 117, no. 12, pp. 7857-7877. https://doi.org/10.1021/acs.chemrev.7b00046
Hedglin, M, Aitha, M & Benkovic, S 2017, 'Monitoring the Retention of Human Proliferating Cell Nuclear Antigen at Primer/Template Junctions by Proteins That Bind Single-Stranded DNA', Biochemistry, vol. 56, no. 27, pp. 3415-3421. https://doi.org/10.1021/acs.biochem.7b00386
Hedglin, M & Benkovic, S 2017, 'Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA', Biochemistry, vol. 56, no. 13, pp. 1824-1835. https://doi.org/10.1021/acs.biochem.6b01213

2016

Hedglin, M, Pandey, B & Benkovic, S 2016, 'Characterization of human translesion DNA synthesis across a UV-induced DNA lesion', eLife, vol. 5, no. OCTOBER2016, e19788. https://doi.org/10.7554/eLife.19788
Hedglin, M, Pandey, B & Benkovic, S 2016, 'Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 13, pp. E1777-E1786. https://doi.org/10.1073/pnas.1523653113

2015

Hedglin, M, Zhang, Y & O'Brien, PJ 2015, 'Probing the DNA structural requirements for facilitated diffusion', Biochemistry, vol. 54, no. 2, pp. 557-566. https://doi.org/10.1021/bi5013707
Hedglin, M & Benkovic, S 2015, 'Regulation of Rad6/Rad18 Activity during DNA Damage Tolerance', Annual Review of Biophysics, vol. 44, pp. 207-228. https://doi.org/10.1146/annurev-biophys-060414-033841

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