Researcher Profile

Researcher Profile

Mark Hedglin

Mark Hedglin

Associate Research Professor, Chemistry
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • DNA
  • Proliferating Cell Nuclear Antigen
  • 3-methyladenine-DNA glycosylase
  • Proteins
  • DNA Damage
  • Single-Stranded DNA
  • DNA-Directed DNA Polymerase
  • Replication Protein A
  • Holoenzymes
  • DNA Repair
  • Facilitated Diffusion
  • DNA Glycosylases

Recent Publications


Li, M, Larsen, L & Hedglin, M 2020, 'Rad6/Rad18 Competes with DNA Polymerases ν and δfor PCNA Encircling DNA', Biochemistry, vol. 59, no. 4, pp. 407-416.
Shin, Y, Hedglin, M & Murakami, KS 2020, 'Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase', Nucleic acids research, vol. 48, no. 4, pp. 2144-2155.


Hedglin, M, Aitha, M, Pedley, A & Benkovic, SJ 2019, 'Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen', Journal of Biological Chemistry, vol. 294, no. 13, pp. 5157-5168.


Hedglin, M & Benkovic, SJ 2017, 'Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours around the Same Obstacle', Chemical Reviews, vol. 117, no. 12, pp. 7857-7877.
Hedglin, M, Aitha, M & Benkovic, SJ 2017, 'Monitoring the Retention of Human Proliferating Cell Nuclear Antigen at Primer/Template Junctions by Proteins That Bind Single-Stranded DNA', Biochemistry, vol. 56, no. 27, pp. 3415-3421.
Hedglin, M & Benkovic, SJ 2017, 'Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA', Biochemistry, vol. 56, no. 13, pp. 1824-1835.


Hedglin, M, Pandey, B & Benkovic, SJ 2016, 'Characterization of human translesion DNA synthesis across a UV-induced DNA lesion', eLife, vol. 5, no. OCTOBER2016, e19788.
Hedglin, M, Pandey, B & Benkovic, SJ 2016, 'Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 13, pp. E1777-E1786.

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