Researcher Profile
Researcher Profile
Nicholas Zaorsky, MD, MS
Assistant Professor, Department of Radiation Oncology
Assistant Professor, Department of Radiology
Assistant Professor, Department of Public Health Sciences
Assistant Professor, Department of Radiology
Assistant Professor, Department of Public Health Sciences
Scientific Program:Cancer Control
Disease Teams:
Breast Cancer
Genitourinary Cancer
Sarcoma Cancer
Institute for CyberScience (ICS) - Associate
Genitourinary Cancer
Sarcoma Cancer
Institute for CyberScience (ICS) - Associate
Research Interests
Dr. Nicholas Zaorsky’s international research has several themes.
First, he writes guidelines for the treatment of prostate cancer. His work centers on the indications, contraindications, logistics and toxicities of different treatment modalities to ensure quality patient care and institutional standards.
Second, his work centers on oncologic meta-analyses, which combine international data to provide summary statements with the highest-level evidence to compare treatments. One of the themes of his work is dose fractionation in radiation oncology - the ideal doses that should be used to treat cancer.
Third, Dr. Zaorsky is an expert in oncology-epidemiology, that is, the study of public health and oncology. His works identify patients who are at highest risk of death from cancer vs. other causes and to compare the effectiveness of different treatment options for cancer. His work has led to the design of clinical trials that focus on lifestyle modification (such as with exercise therapy and diet) for the treatment of cancer.
At Penn State, Dr. Zaorsky has integrated these research interests in the design of his clinical trial Exercise + Radiation Therapy (EXERT). The American Cancer Society, National Comprehensive Cancer Network and American College of Sports Medicine recommend exercise therapy to improve outcomes and limit toxicity. However, to date, most clinical studies of exercise therapy are limited to patients receiving chemotherapy or those with localized (non-metastatic) breast or prostate cancer. The rationale for the EXERT study is that 60 percent of cancer patients receive radiation therapy, and few studies have assessed the role of radiation therapy and exercise therapy outside of localized prostate and breast cancer, two disease sites where survival is generally excellent, and toxicities are limited. The long-term goal is to identify potential for exercise therapy to improve radiation therapy treatment outcomes and toxicities among cancer patients.
- Radiotherapy
- Therapeutics
- Neoplasms
- Prostatic Neoplasms
- Meta-Analysis
- Systematic Reviews
- Survival
- Radiosurgery
- Brachytherapy
- Neoplasm Metastasis
- Mortality
- Non-Small Cell Lung Carcinoma
Recent Publications
2021
Kothari, G, Korte, J, Lehrer, EJ, Zaorsky, NG, Lazarakis, S, Kron, T, Hardcastle, N & Siva, S 2021, 'A systematic review and meta-analysis of the prognostic value of radiomics based models in non-small cell lung cancer treated with curative radiotherapy', Radiotherapy and Oncology, vol. 155, pp. 188-203. https://doi.org/10.1016/j.radonc.2020.10.023
Stoltzfus, KC, Shen, B, Tchelebi, L, Trifiletti, DM, Gusani, NJ, Walter, V, Wang, M & Zaorsky, NG 2021, 'Authors’ Reply: To the Letter to the Editor by Kessel et al', JNCCN Journal of the National Comprehensive Cancer Network, vol. 19, no. 7, pp. XLIII-XLIV. https://doi.org/10.6004/jnccn.2021.7068
Singh, R, Lehrer, EJ, Wang, M, Perlow, HK, Zaorsky, NG, Trifiletti, DM, Bovi, J, Navarria, P, Scoccianti, S, Gondi, V, Brown, PD & Palmer, JD 2021, 'Dose Escalated Radiation Therapy for Glioblastoma Multiforme: An International Systematic Review and Meta-Analysis of 22 Prospective Trials', International Journal of Radiation Oncology Biology Physics, vol. 111, no. 2, pp. 371-384. https://doi.org/10.1016/j.ijrobp.2021.05.001
Levin-Epstein, RG, Jiang, NY, Wang, X, Upadhyaya, SK, Collins, SP, Suy, S, Aghdam, N, Mantz, C, Katz, AJ, Miszczyk, L, Napieralska, A, Namysl-Kaletka, A, Prionas, N, Bagshaw, H, Buyyounouski, MK, Cao, M, Agazaryan, N, Dang, A, Yuan, Y, Kupelian, PA, Zaorsky, NG, Spratt, DE, Mohamad, O, Feng, FY, Mahal, BA, Boutros, PC, Kishan, AU, Juarez, J, Shabsovich, D, Jiang, T, Kahlon, S, Patel, A, Patel, J, Nickols, NG, Steinberg, ML, Fuller, DB & Kishan, AU 2021, 'Dose–response with stereotactic body radiotherapy for prostate cancer: A multi-institutional analysis of prostate-specific antigen kinetics and biochemical control', Radiotherapy and Oncology, vol. 154, pp. 207-213. https://doi.org/10.1016/j.radonc.2020.09.053
Zaorsky, NG & Spratt, DE 2021, 'Elective Nodal Radiotherapy for Prostate Cancer: For None, Some, or all?', International Journal of Radiation Oncology Biology Physics, vol. 111, no. 4, pp. 965-967. https://doi.org/10.1016/j.ijrobp.2021.07.1699
Dinh, TKT, Mitin, T, Bagshaw, HP, Hoffman, KE, Hwang, C, Jeffrey Karnes, R, Kishan, AU, Liauw, SL, Lloyd, S, Potters, L, Showalter, TN, Taira, AV, Vapiwala, N, Zaorsky, NG, D'Amico, AV, Nguyen, PL & Davis, BJ 2021, 'Executive Summary of the American Radium Society Appropriate Use Criteria for Radiation Treatment of Node-Negative Muscle Invasive Bladder Cancer', International Journal of Radiation Oncology Biology Physics, vol. 109, no. 4, pp. 953-963. https://doi.org/10.1016/j.ijrobp.2020.10.031
Zaorsky, NG, Allenby, T, Lin, J, Rosenberg, J, Simone, NL & Schmitz, KH 2021, 'Exercise Therapy and Radiation Therapy for Cancer: A Systematic Review', International Journal of Radiation Oncology Biology Physics, vol. 110, no. 4, pp. 973-983. https://doi.org/10.1016/j.ijrobp.2020.11.024
Stoltzfus, KC, Shen, B, Tchelebi, L, Trifiletti, DM, Gusani, NJ, Walter, V, Wang, M & Zaorsky, NG 2021, 'Impact of facility surgical volume on survival in patients with cancer', JNCCN Journal of the National Comprehensive Cancer Network, vol. 19, no. 5, pp. 495-503. https://doi.org/10.6004/jnccn.2020.7644
Tchelebi, LT, Shen, B, Wang, M, Gusani, NJ, Walter, V, Abrams, R, Verma, V & Zaorsky, NG 2021, 'Impact of radiation therapy facility volume on survival in patients with cancer', Cancer, vol. 127, no. 21, pp. 4081-4090. https://doi.org/10.1002/cncr.33777
Zaorsky, NG, Khunsriraksakul, C, Acri, SL, Liu, DJ, Ba, DM, Lin, JL, Liu, G, Segel, JE, Drabick, JJ, Mackley, HB & Leslie, DL 2021, 'Medical Service Use and Charges for Cancer Care in 2018 for Privately Insured Patients Younger Than 65 Years in the US', JAMA network open, vol. 4, no. 10, 27784. https://doi.org/10.1001/jamanetworkopen.2021.27784
Zaorsky, NG, Wang, X, Garrett, SM, Lehrer, EJ, Lin, C, DeGraff, DJ, Spratt, DE, Trifiletti, DM, Kishan, AU, Showalter, TN, Park, HS, Yang, JT, Chinchilli, VM & Wang, M 2022, 'Pan-cancer analysis of prognostic metastatic phenotypes', International Journal of Cancer, vol. 150, no. 1, pp. 132-141. https://doi.org/10.1002/ijc.33744
Segel, JE, Schaefer, EW, Zaorsky, NG, Hollenbeak, CS, Ramian, H & Raman, JD 2021, 'Potential Winners and Losers: Understanding How the Oncology Care Model May Differentially Affect Hospitals', JCO Oncology Practice, vol. 17, no. 8, pp. e1150-e1161. https://doi.org/10.1200/OP.21.00050
Michael, CM, Lehrer, EJ, Schmitz, KH & Zaorsky, NG 2021, 'Prehabilitation exercise therapy for cancer: A systematic review and meta-analysis', Cancer medicine, vol. 10, no. 13, pp. 4195-4205. https://doi.org/10.1002/cam4.4021
Jiang, T, Markovic, D, Patel, J, Juarez, JE, Ma, TM, Shabsovich, D, Nickols, NG, Reiter, RE, Elashoff, D, Rettig, MB, Zaorsky, NG, Spratt, DE & Kishan, AU 2021, 'Radiation therapy dose and androgen deprivation therapy in localized prostate cancer: a meta-regression of 5-year outcomes in phase III randomized controlled trials', Prostate Cancer and Prostatic Diseases. https://doi.org/10.1038/s41391-021-00432-2
Zaorsky, NG, Calais, J, Fanti, S, Tilki, D, Dorff, T, Spratt, DE & Kishan, AU 2021, 'Salvage therapy for prostate cancer after radical prostatectomy', Nature Reviews Urology, vol. 18, no. 11, pp. 643-668. https://doi.org/10.1038/s41585-021-00497-7
Ha, GL, Lehrer, EJ, Wang, M, Holliday, E, Jagsi, R & Zaorsky, NG 2021, 'Sex Differences in Academic Productivity across Academic Ranks and Specialties in Academic Medicine: A Systematic Review and Meta-analysis', JAMA network open. https://doi.org/10.1001/jamanetworkopen.2021.12404
Siva, S, Ost, P, Zaorsky, N & Staehler, M 2021, 'Stereotactic Radiotherapy for Oligoprogressive Disease: A New Frontier in Kidney Cancer', European Urology, vol. 80, no. 6, pp. 701-702. https://doi.org/10.1016/j.eururo.2021.09.006
Zaorsky, NG, Liang, M, Patel, R, Lin, C, Tchelebi, LT, Newport, KB, Fox, EJ & Wang, M 2021, 'Survival after palliative radiation therapy for cancer: The METSSS model', Radiotherapy and Oncology, vol. 158, pp. 104-111. https://doi.org/10.1016/j.radonc.2021.02.011
Chen, H, Stoltzfus, KC, Lehrer, EJ, Horn, SR, Siva, S, Trifiletti, DM, Meng, MB, Verma, V, Louie, AV & Zaorsky, NG 2021, 'The Epidemiology of Lung Metastases', Frontiers in Medicine, vol. 8, 723396. https://doi.org/10.3389/fmed.2021.723396
Lehrer, EJ, Stoltzfus, KC, Jones, BM, Gusani, NJ, Walter, V, Wang, M, Trifiletti, DM, Siva, S, Louie, AV & Zaorsky, NG 2021, 'Trends in diagnosis and treatment of metastatic cancer in the United States', American Journal of Clinical Oncology: Cancer Clinical Trials. https://doi.org/10.1097/COC.0000000000000866
2020
Valle, LF, Lehrer, EJ, Markovic, D, Elashoff, D, Levin-Epstein, R, Karnes, RJ, Reiter, RE, Rettig, M, Calais, J, Nickols, NG, Dess, RT, Spratt, DE, Steinberg, ML, Nguyen, PL, Davis, BJ, Zaorsky, NG & Kishan, AU 2021, 'A Systematic Review and Meta-analysis of Local Salvage Therapies After Radiotherapy for Prostate Cancer (MASTER)[Formula presented]', European Urology, vol. 80, no. 3, pp. 280-292. https://doi.org/10.1016/j.eururo.2020.11.010
Allenby, TH, Crenshaw, ML, Mathis, K, Champ, CE, Simone, NL, Schmitz, KH, Tchelebi, LT & Zaorsky, NG 2020, 'A systematic review of home-based dietary interventions during radiation therapy for cancer', Technical Innovations and Patient Support in Radiation Oncology, vol. 16, pp. 10-16. https://doi.org/10.1016/j.tipsro.2020.08.001
Zaorsky, NG, Zhang, Y, Tuanquin, L, Bluethmann, SM, Park, HS & Chinchilli, VM 2020, 'Author Correction: Suicide among cancer patients (Nature Communications, (2019), 10, 1, (207), 10.1038/s41467-018-08170-1)', Nature communications, vol. 11, no. 1, 718. https://doi.org/10.1038/s41467-020-14506-7
Singh, R, Lehrer, EJ, Ko, S, Peterson, J, Lou, Y, Porter, AB, Kotecha, R, Brown, PD, Zaorsky, NG & Trifiletti, DM 2020, 'Brain metastases from non-small cell lung cancer with EGFR or ALK mutations: A systematic review and meta-analysis of multidisciplinary approaches', Radiotherapy and Oncology, vol. 144, pp. 165-179. https://doi.org/10.1016/j.radonc.2019.11.010
Greenberger, BA, Zaorsky, NG & Den, RB 2020, 'Comparison of Radical Prostatectomy Versus Radiation and Androgen Deprivation Therapy Strategies as Primary Treatment for High-risk Localized Prostate Cancer: A Systematic Review and Meta-analysis', European Urology Focus, vol. 6, no. 2, pp. 404-418. https://doi.org/10.1016/j.euf.2019.11.007
Tchelebi, LT, Lehrer, EJ, Trifiletti, DM, Sharma, NK, Gusani, NJ, Crane, CH & Zaorsky, NG 2020, 'Conventionally fractionated radiation therapy versus stereotactic body radiation therapy for locally advanced pancreatic cancer (CRiSP): An international systematic review and meta-analysis', Cancer, vol. 126, no. 10, pp. 2120-2131. https://doi.org/10.1002/cncr.32756
Patel, RR, Ludmir, EB, Augustyn, A, Zaorsky, NG, Lehrer, EJ, Ryali, R, Trifiletti, DM, Adeberg, S, Amini, A & Verma, V 2020, 'De-intensification of therapy in human papillomavirus associated oropharyngeal cancer: A systematic review of prospective trials', Oral Oncology, vol. 103, 104608. https://doi.org/10.1016/j.oraloncology.2020.104608
Dess, RT, Suresh, K, Zelefsky, MJ, Freedland, SJ, Mahal, BA, Cooperberg, MR, Davis, BJ, Horwitz, EM, Terris, MK, Amling, CL, Aronson, WJ, Kane, CJ, Jackson, WC, Hearn, JWD, Deville, C, Deweese, TL, Greco, S, McNutt, TR, Song, DY, Sun, Y, Mehra, R, Kaffenberger, SD, Morgan, TM, Nguyen, PL, Feng, FY, Sharma, V, Tran, PT, Stish, BJ, Pisansky, TM, Zaorsky, NG, Moraes, FY, Berlin, A, Finelli, A, Fossati, N, Gandaglia, G, Briganti, A, Carroll, PR, Karnes, RJ, Kattan, MW, Schipper, MJ & Spratt, DE 2020, 'Development and Validation of a Clinical Prognostic Stage Group System for Nonmetastatic Prostate Cancer Using Disease-Specific Mortality Results from the International Staging Collaboration for Cancer of the Prostate', JAMA Oncology, vol. 6, no. 12, pp. 1912-1920. https://doi.org/10.1001/jamaoncol.2020.4922
Zaorsky, NG, Spratt, DE, Kishan, AU, Culp, SH & Showalter, TN 2020, 'Editorial: Optimizing Local Therapy for High-Risk Prostate Cancer: Evidence and Emerging Options', Frontiers in Oncology, vol. 10, 1616. https://doi.org/10.3389/fonc.2020.01616
Ryan, C, Stoltzfus, KC, Horn, S, Chen, H, Louie, AV, Lehrer, EJ, Trifiletti, DM, Fox, EJ, Abraham, JA & Zaorsky, NG 2020, 'Epidemiology of bone metastases', Bone. https://doi.org/10.1016/j.bone.2020.115783
Horn, SR, Stoltzfus, KC, Lehrer, EJ, Dawson, LA, Tchelebi, L, Gusani, NJ, Sharma, NK, Chen, H, Trifiletti, DM & Zaorsky, NG 2020, 'Epidemiology of liver metastases', Cancer Epidemiology, vol. 67, 101760. https://doi.org/10.1016/j.canep.2020.101760
Stoltzfus, KC, Zhang, Y, Sturgeon, K, Sinoway, LI, Trifiletti, DM, Chinchilli, VM & Zaorsky, NG 2020, 'Fatal heart disease among cancer patients', Nature communications, vol. 11, no. 1, 2011. https://doi.org/10.1038/s41467-020-15639-5
Hartman, HE, Sun, Y, Devasia, TP, Chase, EC, Jairath, NK, Dess, RT, Jackson, WC, Morris, E, Li, P, Hochstedler, KA, Abbott, MR, Kidwell, KM, Walter, V, Wang, M, Wang, X, Zaorsky, NG, Schipper, MJ & Spratt, DE 2020, 'Integrated Survival Estimates for Cancer Treatment Delay among Adults with Cancer during the COVID-19 Pandemic', JAMA Oncology, vol. 6, no. 12, pp. 1881-1889. https://doi.org/10.1001/jamaoncol.2020.5403
Horn, SR, Stoltzfus, KC, Mackley, HB, Lehrer, EJ, Zhou, S, Dandekar, SC, Fox, EJ, Rizk, EB, Trifiletti, DM, Rao, PM & Zaorsky, NG 2020, 'Long-term causes of death among pediatric patients with cancer', Cancer, vol. 126, no. 13, pp. 3102-3113. https://doi.org/10.1002/cncr.32885
Zaorsky, NG, Yu, JB, McBride, SM, Dess, RT, Jackson, WC, Mahal, BA, Chen, R, Choudhury, A, Henry, A, Syndikus, I, Mitin, T, Tree, A, Kishan, AU & Spratt, DE 2020, 'Prostate Cancer Radiation Therapy Recommendations in Response to COVID-19', Advances in Radiation Oncology, vol. 5, no. 4, pp. 659-665. https://doi.org/10.1016/j.adro.2020.03.010
Zaorsky, NG 2020, 'Prostate and Pelvis on Pause Pending a Pandemic', International Journal of Radiation Oncology Biology Physics, vol. 108, no. 2, pp. 341-342. https://doi.org/10.1016/j.ijrobp.2020.07.013
Bluethmann, SM, Wang, M, Wasserman, E, Chen, C, Zaorsky, NG, Hohl, RJ & McDonald, AC 2020, 'Prostate cancer in Pennsylvania: The role of older age at diagnosis, aggressiveness, and environmental risk factors on treatment and mortality using data from the Pennsylvania Cancer Registry', Cancer medicine, vol. 9, no. 10, pp. 3623-3633. https://doi.org/10.1002/cam4.3003
Levin-Epstein, R, Cook, RR, Wong, JK, Stock, RG, Jeffrey Demanes, D, Collins, SP, Aghdam, N, Suy, S, Mantz, C, Katz, AJ, Nickols, NG, Miszczyk, L, Napieralska, A, Namysl-Kaletka, A, Prionas, ND, Bagshaw, H, Buyyounouski, MK, Cao, M, Mahal, BA, Shabsovich, D, Dang, A, Yuan, Y, Rettig, MB, Chang, AJ, Jackson, WC, Spratt, DE, Lehrer, EJ, Zaorsky, NG, Kupelian, PA, Steinberg, ML, Horwitz, EM, Jiang, NY & Kishan, AU 2020, 'Prostate-specific antigen kinetics and biochemical control following stereotactic body radiation therapy, high dose rate brachytherapy, and low dose rate brachytherapy: A multi-institutional analysis of 3502 patients', Radiotherapy and Oncology, vol. 151, pp. 26-32. https://doi.org/10.1016/j.radonc.2020.07.014
Zaorsky, NG, O'Brien, E, Mardini, J, Lehrer, EJ, Holliday, E & Weisman, CS 2020, 'Publication productivity and academic rank in medicine: A systematic review and meta-analysis', Academic Medicine, vol. 95, no. 8, pp. 1274-1282. https://doi.org/10.1097/ACM.0000000000003185
Wright, C, Verma, V, Barsky, AR, Haque, W, Polamraju, PV, Ludmir, EB, Zaorsky, NG, Lehrer, EJ, Trifiletti, DM, Grover, S, Friedberg, JS & Simone, CB 2020, 'Quantitation and predictors of short-term mortality following extrapleural pneumonectomy, pleurectomy/decortication, and nonoperative management for malignant pleural mesothelioma', Journal of Thoracic Disease, vol. 12, no. 11, pp. 6476-6493. https://doi.org/10.21037/jtd-20-1779
Tchelebi, LT, Zaorsky, NG, Rosenberg, JC, Sharma, NK, Tuanquin, LC, MacKley, HB & Ellis, RJ 2020, 'Reducing the Toxicity of Radiotherapy for Pancreatic Cancer with Magnetic Resonance-guided Radiotherapy', Toxicological Sciences, vol. 175, no. 1, pp. 19-23. https://doi.org/10.1093/toxsci/kfaa021
Correa, RJM, Louie, AV, Zaorsky, NG, Lehrer, EJ, Ellis, R, Ponsky, L, Kaplan, I, Mahadevan, A, Chu, W, Swaminath, A, Hannan, R, Onishi, H, Teh, BS, Muacevic, A, Lo, SS, Staehler, M & Siva, S 2021, 'Reply to Francesco Montorsi, Alessandro Larcher, and Umberto Capitanio's Letter to the Editor re: Rohann J.M. Correa, Alexander V. Louie, Nicholas G. Zaorsky, et al. The Emerging Role of Stereotactic Ablative Radiotherapy for Primary Renal Cell Carcinoma: A Systematic Review and Meta-Analysis. Eur Urol Focus. 2019 Jun 24. pii: S2405-4569(19)30157-9. https://doi.org/10.1016/j.euf.2019.06.002. [Epub ahead of print]', European Urology Focus, vol. 7, no. 2, pp. 404-405. https://doi.org/10.1016/j.euf.2019.10.004
Lehrer, EJ, Singh, R, Wang, M, Chinchilli, VM, Trifiletti, DM, Ost, P, Siva, S, Meng, MB, Tchelebi, L & Zaorsky, NG 2021, 'Safety and Survival Rates Associated with Ablative Stereotactic Radiotherapy for Patients with Oligometastatic Cancer: A Systematic Review and Meta-analysis', JAMA Oncology, vol. 7, no. 1, e205865, pp. 92-106. https://doi.org/10.1001/jamaoncol.2020.6146
Zaorsky, NG & Kishan, AU 2020, 'Salvage therapy at biochemical recurrence of prostate cancer', Nature Reviews Urology, vol. 17, no. 4, pp. 195-196. https://doi.org/10.1038/s41585-020-0290-3
Singh, R, Lehrer, EJ, Dahshan, B, Palmer, JD, Sahgal, A, Gerszten, PC, Zaorsky, NG & Trifiletti, DM 2020, 'Single fraction radiosurgery, fractionated radiosurgery, and conventional radiotherapy for spinal oligometastasis (SAFFRON): A systematic review and meta-analysis', Radiotherapy and Oncology, vol. 146, pp. 76-89. https://doi.org/10.1016/j.radonc.2020.01.030
Sha, CM, Lehrer, EJ, Hwang, C, Trifiletti, DM, Mackley, HB, Drabick, JJ & Zaorsky, NG 2020, 'Toxicity in combination immune checkpoint inhibitor and radiation therapy: A systematic review and meta-analysis', Radiotherapy and Oncology, vol. 151, pp. 141-148. https://doi.org/10.1016/j.radonc.2020.07.035
Scott, AR, Stoltzfus, KC, Tchelebi, LT, Trifiletti, DM, Lehrer, EJ, Rao, P, Bleyer, A & Zaorsky, NG 2020, 'Trends in Cancer Incidence in US Adolescents and Young Adults, 1973-2015', JAMA network open, vol. 3, no. 12, pp. e2027738. https://doi.org/10.1001/jamanetworkopen.2020.27738
Lehrer, EJ, Kishan, AU, Yu, JB, Trifiletti, DM, Showalter, TN, Ellis, R & Zaorsky, NG 2020, 'Ultrahypofractionated versus hypofractionated and conventionally fractionated radiation therapy for localized prostate cancer: A systematic review and meta-analysis of phase III randomized trials', Radiotherapy and Oncology, vol. 148, pp. 235-242. https://doi.org/10.1016/j.radonc.2020.04.037
Sanmamed, N, Glicksman, RM, Herrera-Caceres, J, Lehrer, EJ, Heaton, J, Hansen, AR, Chung, P, Fleshner, NE, Den, RB, Zaorsky, NG & Berlin, A 2020, 'Use of combined androgen deprivation therapy with postoperative radiation treatment for prostate cancer: Impact of randomized trials on clinical practice', Urologic Oncology: Seminars and Original Investigations, vol. 38, no. 11, pp. 848.e1-848.e7. https://doi.org/10.1016/j.urolonc.2020.04.019
2019
Sturgeon, KM, Deng, L, Bluethmann, SM, Zhou, S, Trifiletti, DM, Jiang, C, Kelly, SP & Zaorsky, NG 2019, 'A population-based study of cardiovascular disease mortality risk in US cancer patients', European Heart Journal, vol. 40, no. 48, pp. 3889-3897. https://doi.org/10.1093/eurheartj/ehz766
Zaorsky, NG, Zhang, Y, Walter, V, Tchelebi, LT, Chinchilli, VM & Gusani, NJ 2019, 'Clinical trial accrual at initial course of therapy for cancer and its impact on survival', JNCCN Journal of the National Comprehensive Cancer Network, vol. 17, no. 11, pp. 1309-1316. https://doi.org/10.6004/jnccn.2019.7321
Chowdhary, M, Chowdhary, A, Sen, N, Zaorsky, NG, Patel, KR & Wang, D 2019, 'Does the addition of chemotherapy to neoadjuvant radiotherapy impact survival in high-risk extremity/trunk soft-tissue sarcoma?', Cancer, vol. 125, no. 21, pp. 3801-3809. https://doi.org/10.1002/cncr.32386
Cummings, M, Lehrer, EJ, Drabick, J, Gusani, NJ, Trifiletti, DM & Zaorsky, N 2019, 'Exceptional responders in oncology: A systematic review and meta-analysis of patient level data', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 42, no. 8, pp. 624-635. https://doi.org/10.1097/COC.0000000000000572
Dang, AT, Levin-Epstein, RG, Shabsovich, D, Cao, M, King, C, Chu, FI, Mantz, CA, Stephans, KL, Reddy, CA, Loblaw, DA, Cheung, P, Scorsetti, M, Cozzi, L, DeNittis, AS, Wang, Y, Zaorsky, N, Nickols, NG, Kupelian, PA, Steinberg, ML & Kishan, AU 2020, 'Gantry-Mounted Linear Accelerator–Based Stereotactic Body Radiation Therapy for Low- and Intermediate-Risk Prostate Cancer', Advances in Radiation Oncology, vol. 5, no. 3, pp. 404-411. https://doi.org/10.1016/j.adro.2019.09.010
Zaorsky, NG, Spratt, DE & Blanchard, P 2019, 'Re: Marco Moschini, Emanuele Zaffuto, Pierre I. Karakiewicz, et al. External Beam Radiotherapy Increases the Risk of Bladder Cancer When Compared with Radical Prostatectomy in Patients Affected by Prostate Cancer: A Population-based Analysis. Eur Urol 2019;75:319–28', European Urology, vol. 75, no. 4, pp. e96-e97. https://doi.org/10.1016/j.eururo.2018.11.025
Meng, MB, Wang, HH, Zaorsky, NG, Sun, BS, Zhu, L, Song, YC, Li, FT, Dong, Y, Wang, JS, Chen, HM, Yu, XY & Yuan, ZY 2019, 'Risk-adapted stereotactic body radiation therapy for central and ultra-central early-stage inoperable non-small cell lung cancer', Cancer Science, vol. 110, no. 11, pp. 3553-3564. https://doi.org/10.1111/cas.14185
Lehrer, EJ, Peterson, JL, Zaorsky, N, Brown, PD, Sahgal, A, Chiang, VL, Chao, ST, Sheehan, JP & Trifiletti, DM 2019, 'Single versus Multifraction Stereotactic Radiosurgery for Large Brain Metastases: An International Meta-analysis of 24 Trials', International Journal of Radiation Oncology Biology Physics, vol. 103, no. 3, pp. 618-630. https://doi.org/10.1016/j.ijrobp.2018.10.038
Zaorsky, NG, Lehrer, EJ, Kothari, G, Louie, AV & Siva, S 2019, 'Stereotactic ablative radiation therapy for oligometastatic renal cell carcinoma (SABR ORCA): a meta-analysis of 28 studies', European Urology Oncology. https://doi.org/10.1016/j.euo.2019.05.007
Zaorsky, NG, Zhang, Y, Tchelebi, LT, Mackley, HB, Chinchilli, VM & Zacharia, BE 2019, 'Stroke among cancer patients', Nature communications, vol. 10, no. 1, 5172. https://doi.org/10.1038/s41467-019-13120-6
Zaorsky, NG, Zhang, Y, Tuanquin, L, Bluethmann, SM, Park, HS & Chinchilli, VM 2019, 'Suicide among cancer patients', Nature communications, vol. 10, no. 1, 207. https://doi.org/10.1038/s41467-018-08170-1
Lee, CT, Lehrer, EJ, Aphale, A, Lango, M, Galloway, TJ & Zaorsky, NG 2019, 'Surgical excision, Mohs micrographic surgery, external-beam radiotherapy, or brachytherapy for indolent skin cancer: An international meta-analysis of 58 studies with 21,000 patients', Cancer, vol. 125, no. 20, pp. 3582-3594. https://doi.org/10.1002/cncr.32371
Correa, RJM, Louie, AV, Zaorsky, NG, Lehrer, EJ, Ellis, R, Ponsky, L, Kaplan, I, Mahadevan, A, Chu, W, Swaminath, A, Hannan, R, Onishi, H, Teh, BS, Muacevic, A, Lo, SS, Staehler, M & Siva, S 2019, 'The Emerging Role of Stereotactic Ablative Radiotherapy for Primary Renal Cell Carcinoma: A Systematic Review and Meta-Analysis', European Urology Focus, vol. 5, no. 6, pp. 958-969. https://doi.org/10.1016/j.euf.2019.06.002
Malouff, TD, Vallow, LA, Waddle, MR, Kaleem, T, Zaorsky, NG, Royce, TJ, Stross, WC, May, B & Trifiletti, DM 2019, 'The Influence of Online Forums on Radiation Oncology Residency Program Selection', International Journal of Radiation Oncology Biology Physics, vol. 104, no. 5, pp. 1009-1011. https://doi.org/10.1016/j.ijrobp.2019.04.011
Chowdhary, M, Song, A, Zaorsky, NG & Shi, W 2019, 'Total skin electron beam therapy in mycosis fungoides—a shift towards lower dose?', Chinese clinical oncology, vol. 8, no. 1, 9. https://doi.org/10.21037/cco.2018.09.02
Lin, D, Lehrer, EJ, Rosenberg, J, Trifiletti, DM & Zaorsky, NG 2019, 'Toxicity after radiotherapy in patients with historically accepted contraindications to treatment (CONTRAD): An international systematic review and meta-analysis', Radiotherapy and Oncology, vol. 135, pp. 147-152. https://doi.org/10.1016/j.radonc.2019.03.006
2018
Wang, HH, Wu, ZQ, Qian, D, Zaorsky, NG, Qiu, MH, Cheng, JJ, Jiang, C, Wang, J, Zeng, XL, Liu, CL, Tian, LJ, Ying, GG, Meng, MB, Hao, XS & Yuan, ZY 2018, 'Ablative Hypofractionated Radiation Therapy Enhances Non-Small Cell Lung Cancer Cell Killing via Preferential Stimulation of Necroptosis In Vitro and In Vivo', International Journal of Radiation Oncology Biology Physics, vol. 101, no. 1, pp. 49-62. https://doi.org/10.1016/j.ijrobp.2018.01.036
Alonso, C, Dutta, SW, Mitra, N, Landsburg, DJ, Zaorsky, NG, Grover, S, Peterson, J & Trifiletti, DM 2018, 'Adult nodular lymphocyte-predominant Hodgkin lymphoma: treatment modality utilization and survival', Cancer medicine, vol. 7, no. 4, pp. 1118-1126. https://doi.org/10.1002/cam4.1383
Churilla, TM, DeMora, L, Handorf, E, Zaorsky, NG, Dong, Y, Denlinger, CS, Sigurdson, ER & Meyer, JE 2018, 'Deviations From Standard Chemoradiation Among Early-Stage Anal Cancer Patients', International Journal of Radiation Oncology Biology Physics, vol. 100, no. 4, pp. 945-949. https://doi.org/10.1016/j.ijrobp.2017.12.003
Zaorsky, NG, Lehrer, EJ, Handorf, E & Meyer, JE 2019, 'Dose escalation in stereotactic body radiation therapy for pancreatic cancer', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 42, no. 1, pp. 46-55. https://doi.org/10.1097/COC.0000000000000472
Zaorsky, N, Ahmed, AA, Zhu, J, Yoo, SK, Fuller, CD, Thomas, CR, Choi, M & Holliday, EB 2019, 'Industry Funding Is Correlated With Publication Productivity of US Academic Radiation Oncologists', Journal of the American College of Radiology, vol. 16, no. 2, pp. 244-251. https://doi.org/10.1016/j.jacr.2018.07.024
Du, S, Zhou, L, Alexander, GS, Park, K, Yang, L, Wang, N, Zaorsky, NG, Ma, X, Wang, Y, Dicker, AP & Lu, B 2018, 'PD-1 Modulates Radiation-Induced Cardiac Toxicity through Cytotoxic T Lymphocytes', Journal of Thoracic Oncology, vol. 13, no. 4, pp. 510-520. https://doi.org/10.1016/j.jtho.2017.12.002
Zaorsky, NG, Lee, CT, Zhang, E & Galloway, TJ 2018, 'Skin CanceR Brachytherapy vs External beam radiation therapy (SCRiBE) meta-analysis', Radiotherapy and Oncology, vol. 126, no. 3, pp. 386-393. https://doi.org/10.1016/j.radonc.2017.12.029
Tchelebi, L, Zaorsky, N & Mackley, H 2018, 'Stereotactic body radiation therapy in the management of upper GI malignancies', Biomedicines, vol. 6, no. 1, 7. https://doi.org/10.3390/biomedicines6010007
Lehrer, EJ, McGee, HM, Peterson, JL, Vallow, L, Ruiz-Garcia, H, Zaorsky, NG, Sharma, S & Trifiletti, DM 2018, 'Stereotactic radiosurgery and immune checkpoint inhibitors in the management of brain metastases', International journal of molecular sciences, vol. 19, no. 10, 3054. https://doi.org/10.3390/ijms19103054
Lehrer, EJ, Peterson, J, Brown, PD, Sheehan, JP, Quiñones-Hinojosa, A, Zaorsky, NG & Trifiletti, DM 2019, 'Treatment of brain metastases with stereotactic radiosurgery and immune checkpoint inhibitors: An international meta-analysis of individual patient data', Radiotherapy and Oncology, vol. 130, pp. 104-112. https://doi.org/10.1016/j.radonc.2018.08.025
2017
Zaorsky, NG, Showalter, TN, Ezzell, GA, Nguyen, PL, Assimos, DG, D'Amico, AV, Gottschalk, AR, Gustafson, GS, Keole, SR, Liauw, SL, Lloyd, S, McLaughlin, PW, Movsas, B, Prestidge, BR, Taira, AV, Vapiwala, N & Davis, BJ 2017, 'ACR Appropriateness Criteria for external beam radiation therapy treatment planning for clinically localized prostate cancer, part II of II', Advances in Radiation Oncology, vol. 2, no. 3, pp. 437-454. https://doi.org/10.1016/j.adro.2017.03.003
Expert Panel on Radiation Oncology-Prostate: 2017, 'ACR Appropriateness Criteria® external beam radiation therapy treatment planning for clinically localized prostate cancer, part I of II', Advances in Radiation Oncology, vol. 2, no. 1, pp. 62-84. https://doi.org/10.1016/j.adro.2016.10.002
De Bari, B, Stish, B, Ball, MW, Habboush, Y, Sargos, P, Krengli, M, Bossi, A, Stabile, A, Sole Pesutic, C, Lestrade, L, Smeenk, RJ, Jereczek-Fossa, BA, Zilli, T, Créhange, G, Alongi, F, Zaorsky, N & Ozsahin, M 2017, 'Adult prostatic sarcoma: A contemporary multicenter Rare Cancer Network study', Prostate, vol. 77, no. 10, pp. 1160-1166. https://doi.org/10.1002/pros.23375
Zaorsky, NG, Churilla, TM, Egleston, BL, Fisher, SG, Ridge, JA, Horwitz, EM & Meyer, JE 2017, 'Causes of death among cancer patients', Annals of Oncology, vol. 28, no. 2, pp. 400-407. https://doi.org/10.1093/annonc/mdw604
Wang, HH, Deng, L, Wen, QL, Zhang, CZ, Zaorsky, NG, Zhang, BL, Chen, J, Zeng, XL, Cui, YL, Shi, YY, Hou, HL, Wang, W, Jiang, B, Wang, J, Pang, QS, Zhao, LJ, Yuan, ZY, Wang, P & Meng, MB 2017, 'Early postoperative radiotherapy is associated with improved outcomes over late postoperative radiotherapy in the management of completely resected (R0) Stage IIIA-N2 nonsmall cell lung cancer', Oncotarget, vol. 8, no. 38, pp. 62998-63013. https://doi.org/10.18632/oncotarget.18071
Dong, Y, Zaorsky, NG, Li, T, Churilla, TM, Viterbo, R, Sobczak, ML, Smaldone, MC, Chen, DYT, Uzzo, RG, Hallman, MA & Horwitz, EM 2018, 'Effects of interruptions of external beam radiation therapy on outcomes in patients with prostate cancer', Journal of Medical Imaging and Radiation Oncology, vol. 62, no. 1, pp. 116-121. https://doi.org/10.1111/1754-9485.12675
Zaorsky, NG, Lee, CT, Zhang, E, Keith, SW & Galloway, TJ 2017, 'Hypofractionated radiation therapy for basal and squamous cell skin cancer: A meta-analysis', Radiotherapy and Oncology, vol. 125, no. 1, pp. 13-20. https://doi.org/10.1016/j.radonc.2017.08.011
Zaorsky, NG, Shaikh, T, Ruth, K, Sharda, P, Hayes, SB, Sobczak, ML, Hallman, MA, Smaldone, MC, Chen, DYT & Horwitz, EM 2017, 'Prostate Cancer Patients With Unmanaged Diabetes or Receiving Insulin Experience Inferior Outcomes and Toxicities After Treatment With Radiation Therapy', Clinical Genitourinary Cancer, vol. 15, no. 2, pp. 326-335.e3. https://doi.org/10.1016/j.clgc.2016.08.020
Zaorsky, NG, Williams, GR, Barta, SK, Esnaola, NF, Kropf, PL, Hayes, SB & Meyer, JE 2017, 'Splenic irradiation for splenomegaly: A systematic review', Cancer Treatment Reviews, vol. 53, pp. 47-52. https://doi.org/10.1016/j.ctrv.2016.11.016
Williams, NL, Dan, T, Zaorsky, N, Garg, S & Den, RB 2017, 'The Role of Genomic Techniques in Predicting Response to Radiation Therapy', Oncology (Williston Park, N.Y.), vol. 31, no. 7, pp. 562-570.
Zaorsky, NG, Davis, BJ, Nguyen, PL, Showalter, TN, Hoskin, PJ, Yoshioka, Y, Morton, GC & Horwitz, EM 2017, 'The evolution of brachytherapy for prostate cancer', Nature Reviews Urology, vol. 14, no. 7, pp. 415-439. https://doi.org/10.1038/nrurol.2017.76
Williams, NL, Dan, T, Zaorsky, N, Garg, S & Den, RB 2017, 'The role of genomic techniques in predicting response to radiation therapy', ONCOLOGY (United States), vol. 31, no. 7, pp. 1-11.