Researcher Profile

Researcher Profile

Siyang Zheng, PhD

Siyang Zheng, PhD

Associate Professor, Biomedical Engineering
Scientific Program:Experimental Therapeutics
sxz10@psu.edu

Research Interests

  • Circulating Neoplastic Cells
  • Equipment and Supplies
  • Neoplasms
  • Therapeutics
  • Enzymes
  • Proteins
  • Viruses
  • Microfluidics
  • Neoplasm Metastasis
  • Electrodes
  • Technology
  • Carbon Nanotubes

Recent Publications

2019

Wan, Y & Zheng, S 2019, 'Enhanced detection of tumour-secreted vesicles', Nature Biomedical Engineering, vol. 3, no. 6, pp. 421-422. https://doi.org/10.1038/s41551-019-0415-2
Wan, Y, Maurer, M, He, HZ, Xia, YQ, Hao, SJ, Zhang, WL, Yee, NS-S & Zheng, S 2019, 'Enrichment of extracellular vesicles with lipid nanoprobe functionalized nanostructured silica', Lab on a Chip, vol. 19, no. 14, pp. 2346-2355. https://doi.org/10.1039/c8lc01359d

2018

Yeh, Y-T, Lu, H, Zheng, S & Terrones Maldonado, M 2018, A Portable Device Integrated with Aligned Carbon Nanotubes for Sensitive Virus Capture and Detection. in 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. vol. 2018-July, 8513515, Institute of Electrical and Electronics Engineers Inc., pp. 6072-6075, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018, Honolulu, United States, 7/18/18. https://doi.org/10.1109/EMBC.2018.8513515
Hao, S, Ha, L, Cheng, G, Wan, Y, Xia, Y, Sosnoski, DM, Mastro, AM & Zheng, S 2018, 'A Spontaneous 3D Bone-On-a-Chip for Bone Metastasis Study of Breast Cancer Cells', Small, vol. 14, no. 12, 1702787. https://doi.org/10.1002/smll.201702787
Yeh, Y-T, Lin, Z, Zheng, S & Terrones Maldonado, M 2018, 'A carbon nanotube integrated microfluidic device for blood plasma extraction' Scientific reports, vol. 8, no. 1, 13623. https://doi.org/10.1038/s41598-018-31810-x
Wan, Y, Wang, L, Zhu, C, Zheng, Q, Wang, G, Tong, J, Fang, Y, Xia, Y, Cheng, G, He, X & Zheng, S 2018, 'Aptamer-conjugated extracellular nanovesicles for targeted drug delivery', Cancer Research, vol. 78, no. 3, pp. 798-808. https://doi.org/10.1158/0008-5472.CAN-17-2880
Cheng, G, Han, XH, Hao, SJ, Nisic, M & Zheng, S 2018, 'In Situ Caging of Biomolecules in Graphene Hybrids for Light Modulated Bioactivity', ACS Applied Materials and Interfaces, vol. 10, no. 4, pp. 3361-3371. https://doi.org/10.1021/acsami.7b17544
Yeh, Y-T, Tang, Y, Lin, Z, Fujisawa, K, Lei, Y, Zhou, Y, Rotella, C, Elias Arriaga, AL, Zheng, S, Mao, Y, Liu, Z, Lu, H & Terrones Maldonado, M 2018, 'Light-Emitting Transition Metal Dichalcogenide Monolayers under Cellular Digestion', Advanced Materials, vol. 30, no. 8, 1703321. https://doi.org/10.1002/adma.201703321
Li, WQ, Wang, Z, Hao, S, Sun, L, Nisic, M, Cheng, G, Zhu, C, Wan, Y, Ha, L & Zheng, S 2018, 'Mitochondria-based aircraft carrier enhances in vivo imaging of carbon quantum dots and delivery of anticancer drug', Nanoscale, vol. 10, no. 8, pp. 3744-3752. https://doi.org/10.1039/c7nr08816g
Wan, Y, Liu, B, Lei, H, Zhang, B, Wang, Y, Huang, H, Chen, S, Feng, Y, Zhu, L, Gu, Y, Zhang, Q, Ma, H & Zheng, S 2018, 'Nanoscale extracellular vesicle-derived DNA is superior to circulating cell-free DNA for mutation detection in early-stage non-small-cell lung cancer', Annals of Oncology, vol. 29, no. 12, pp. 2379-2383. https://doi.org/10.1093/annonc/mdy458
Xia, Y, Wan, Y, Hao, S, Nisic, M, Harouaka, RA, Chen, Y, Zou, X & Zheng, S 2018, 'Nucleus of Circulating Tumor Cell Determines Its Translocation Through Biomimetic Microconstrictions and Its Physical Enrichment by Microfiltration' Small, vol. 14, no. 44, 1802899. https://doi.org/10.1002/smll.201802899
Li, WQ, Sun, LP, Xia, Y, Hao, S, Cheng, G, Wang, Z, Wan, Y, Zhu, C, He, H & Zheng, S 2018, 'Preoccupation of Empty Carriers Decreases Endo-/Lysosome Escape and Reduces the Protein Delivery Efficiency of Mesoporous Silica Nanoparticles', ACS Applied Materials and Interfaces, vol. 10, no. 6, pp. 5340-5347. https://doi.org/10.1021/acsami.7b18577
Cheng, G, Li, W, Ha, L, Han, X, Hao, S, Wan, Y, Wang, Z, Dong, F, Zou, X, Mao, Y & Zheng, S 2018, 'Self-Assembly of Extracellular Vesicle-like Metal-Organic Framework Nanoparticles for Protection and Intracellular Delivery of Biofunctional Proteins', Journal of the American Chemical Society, vol. 140, no. 23, pp. 7282-7291. https://doi.org/10.1021/jacs.8b03584
Hao, SJ, Wan, Y, Xia, YQ, Zou, X & Zheng, S 2018, 'Size-based separation methods of circulating tumor cells', Advanced Drug Delivery Reviews, vol. 125, pp. 3-20. https://doi.org/10.1016/j.addr.2018.01.002

2017

Yu, X, Xia, Y, Tang, Y, Zhang, WL, Yeh, Y-T, Lu, H & Zheng, S 2017, 'A Nanostructured Microfluidic Immunoassay Platform for Highly Sensitive Infectious Pathogen Detection', Small, vol. 13, no. 24, 1700425. https://doi.org/10.1002/smll.201700425
Hao, S, Cheng, G, Wan, Y, Xia, Y, Sosnoski, DM, Mastro, AM & Zheng, S 2017, A bone-on-a-chip microdevice for long-term spontaneous 3D bone tissue formation and cancer bone metastasis. in TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems., 7994514, TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems, Institute of Electrical and Electronics Engineers Inc., pp. 2203-2206, 19th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2017, Kaohsiung, Taiwan, Province of China, 6/18/17. https://doi.org/10.1109/TRANSDUCERS.2017.7994514
Zhou, MD, Akbar, M, Myrick, AJ, Xia, Y, Khan, WJ, Gao, X, Baker, TC & Zheng, S 2017, 'Chopper-modulated gas chromatography electroantennography enabled using high-temperature MEMS flow control device', Microsystems and Nanoengineering, vol. 3, 17062. https://doi.org/10.1038/micronano.2017.62
Yeh, Y-T, Harouaka, RA & Zheng, S 2017, 'Evaluating a novel dimensional reduction approach for mechanical fractionation of cells using a tandem flexible micro spring array (tFMSA)', Lab on a Chip, vol. 17, no. 4, pp. 691-701. https://doi.org/10.1039/c6lc01527a
Xia, Y, Tang, Y, Yu, X, Wan, Y, Chen, Y, Lu, H & Zheng, S 2017, 'Label-Free Virus Capture and Release by a Microfluidic Device Integrated with Porous Silicon Nanowire Forest', Small, vol. 13, no. 6, 1603135. https://doi.org/10.1002/smll.201603135
Li, WQ, Wang, Z, Hao, S, He, H, Wan, Y, Zhu, C, Sun, LP, Cheng, G & Zheng, S 2017, 'Mitochondria-Targeting Polydopamine Nanoparticles to Deliver Doxorubicin for Overcoming Drug Resistance', ACS Applied Materials and Interfaces, vol. 9, no. 20, pp. 16793-16802. https://doi.org/10.1021/acsami.7b01540
Wan, Y, Cheng, G, Liu, X, Hao, SJ, Nisic, M, Zhu, CD, Xia, YQ, Li, WQ, Wang, ZG, Zhang, WL, Rice, SJ, Sebastian, A, Albert, I, Belani, C & Zheng, S 2017, 'Rapid magnetic isolation of extracellular vesicles via lipid-based nanoprobes', Nature Biomedical Engineering, vol. 1, no. 4, 0058. https://doi.org/10.1038/s41551-017-0058
Cheng, G, Hao, SJ, Wan, Y, Shan, DY, Yang, J & Zheng, S 2017, 'Self-Assembly of Smart Multifunctional Hybrid Compartments with Programmable Bioactivity', Chemistry of Materials, vol. 29, no. 5, pp. 2081-2089. https://doi.org/10.1021/acs.chemmater.6b04326
Hao, S, Nisic, M, He, H, Tai, YC & Zheng, S 2017, Separable bilayer microfiltration device for label-free enrichment of viable circulating tumor cells. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1634, Humana Press Inc., pp. 81-91. https://doi.org/10.1007/978-1-4939-7144-2_6
Yu, X, Xia, Y, Tang, Y, Zhang, WL, Yeh, Y-T, Lu, H & Zheng, S 2017, Zinc oxide nanorod integrated microdevice for multiplex virus detection. in TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems., 7994182, Institute of Electrical and Electronics Engineers Inc., pp. 850-853, 19th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2017, Kaohsiung, Taiwan, Province of China, 6/18/17. https://doi.org/10.1109/TRANSDUCERS.2017.7994182

2016

Matthew, EM, Zhou, L, Yang, Z, Dicker, DT, Holder, S, Lim, B, Harouaka, R, Zheng, S, Drabick, J, Lamparella, NE, Truica, C & El-Deiry, WS 2016, 'A multiplexed marker-based algorithm for diagnosis of carcinoma of unknown primary using circulating tumor cells', Oncotarget, vol. 7, no. 4, pp. 3662-3676. https://doi.org/10.18632/oncotarget.6657
Zhang, C, Cheng, G, Edwards, P, Zhou, MD, Zheng, S & Liu, Z 2016, 'G-Fresnel smartphone spectrometer', Lab on a Chip, vol. 16, no. 2, pp. 246-250. https://doi.org/10.1039/c5lc01226k
Cheng, G, Wang, ZG, Denagamage, S & Zheng, S 2016, 'Graphene-Templated Synthesis of Magnetic Metal Organic Framework Nanocomposites for Selective Enrichment of Biomolecules', ACS Applied Materials and Interfaces, vol. 8, no. 16, pp. 10234-10242. https://doi.org/10.1021/acsami.6b02209
Guo, J, Wang, W, Hu, J, Xie, D, Gerhard, E, Nisic, M, Shan, D, Qian, G, Zheng, S & Yang, J 2016, 'Synthesis and characterization of anti-bacterial and anti-fungal citrate-based mussel-inspired bioadhesives', Biomaterials, vol. 85, pp. 204-217. https://doi.org/10.1016/j.biomaterials.2016.01.069
Yu, X, Cheng, G & Zheng, S 2016, 'Synthesis of Self-Assembled Multifunctional Nanocomposite Catalysts with Highly Stabilized Reactivity and Magnetic Recyclability', Scientific reports, vol. 6, 25459. https://doi.org/10.1038/srep25459
Yeh, Y-T, Tang, Y, Sebastian, A, Dasgupta, A, Perea Lopez, N, Albert, I, Lu, H, Terrones Maldonado, M & Zheng, S 2016, 'Tunable and label-free virus enrichment for ultrasensitive virus detection using carbon nanotube arrays', Science advances, vol. 2, no. 10, e1601026. https://doi.org/10.1126/sciadv.1601026

2015

Yeh, Y-T, Tang, Y, Lu, H, Terrones Maldonado, M & Zheng, S 2015, A VACNT integrated handheld device for label-free virus capture, detection and enrichment for genomic analysis. in 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015., 7181031, Institute of Electrical and Electronics Engineers Inc., pp. 747-750, 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015, Anchorage, United States, 6/21/15. https://doi.org/10.1109/TRANSDUCERS.2015.7181031
Ma, Y, Hao, S, Wang, S, Zhao, Y, Lim, B, Lei, M, Spector, DJ, El-Deiry, WS, Zheng, S & Zhu, J 2015, 'A combinatory strategy for detection of live CTCs using microfiltration and a new telomerase-selective adenovirus', BMJ open, vol. 5, no. 2, 007716. https://doi.org/10.1158/1535-7163
Xia, Y & Zheng, S 2015, A mcirofluidic device of biodegradable porous silicon nanowires for size based capturing and releasing viruses. in 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015., 7180956, 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015, Institute of Electrical and Electronics Engineers Inc., pp. 444-447, 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015, Anchorage, United States, 6/21/15. https://doi.org/10.1109/TRANSDUCERS.2015.7180956
Kaifi, JT, Kunkel, M, Das, A, Harouaka, RA, Dicker, DT, Li, G, Zhu, J, Clawson, G, Yang, Z, Reed, MF, Gusani, NJ, Kimchi, ET, Staveley-O’Carroll, KF, Zheng, S & El-Deiry, WS 2015, 'Circulating tumor cell isolation during resection of colorectal cancer lung and liver metastases: A prospective trial with different detection techniques', Cancer Biology and Therapy, vol. 16, no. 5, pp. 699-708. https://doi.org/10.1080/15384047.2015.1030556
Cheng, G, Hao, SJ & Zheng, S 2015, Construction of graphene-based enzyme system for rapid photo-assisted proteolysis. in 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015., 7181188, Institute of Electrical and Electronics Engineers Inc., pp. 1374-1377, 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015, Anchorage, United States, 6/21/15. https://doi.org/10.1109/TRANSDUCERS.2015.7181188
Yu, X & Zheng, S 2015, DNA biosensor by using magnetic nanomaterials and serial signal amplification strategy. in MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, pp. 1671-1673, 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015, Gyeongju, Korea, Republic of, 10/25/15.
Zhou, MD, Hao, S, Williams, AJ, Harouaka, RA, Schrand, B, Rawal, S, Ao, Z, Brenneman, R, Gilboa, E, Lu, B, Wang, S, Zhu, J, Datar, R, Cote, R, Tai, YC & Zheng, S 2015, 'Erratum: Separable bilayer microfiltration device for viable label-free enrichment of circulating tumour cells (Biomedical Engineering Tumour Biomarkers (2014) 4 (7392) 10.1038/srep07392)', Scientific reports, vol. 5. https://doi.org/10.1038/srep07967
Tang, Y, Lu, H, Sebastian, A, Yeh, Y-T, Praul, CA, Albert, I & Zheng, S 2015, 'Genomic characterization of a turkey reovirus field strain by Next-Generation Sequencing', Infection, Genetics and Evolution, vol. 32, pp. 313-321. https://doi.org/10.1016/j.meegid.2015.03.029
Yu, X, Zhang, ZL & Zheng, S 2015, 'Highly sensitive DNA detection using cascade amplification strategy based on hybridization chain reaction and enzyme-induced metallization', Biosensors and Bioelectronics, vol. 66, pp. 520-526. https://doi.org/10.1016/j.bios.2014.11.035
Yeh, Y-T, Xia, Y, Yu, X & Zheng, S 2015, Nanomaterial integrated microfluidic devices for virus analysis. in 2015 IEEE SENSORS - Proceedings., 7370496, 2015 IEEE SENSORS - Proceedings, Institute of Electrical and Electronics Engineers Inc., 14th IEEE SENSORS, Busan, Korea, Republic of, 11/1/15. https://doi.org/10.1109/ICSENS.2015.7370496
Cheng, G, Hao, SJ, Yu, X & Zheng, S 2015, 'Nanostructured microfluidic digestion system for rapid high-performance proteolysis' Lab on a Chip, vol. 15, no. 3, pp. 650-654. https://doi.org/10.1039/c4lc01165a
Yu, X, Cheng, G, Zhou, MD & Zheng, S 2015, 'On-demand one-step synthesis of monodisperse functional polymeric microspheres with droplet microfluidics', Langmuir, vol. 31, no. 13, pp. 3982-3992. https://doi.org/10.1021/acs.langmuir.5b00617

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