Researcher Profile

Researcher Profile

Nadine Hempel, PhD

Nadine Hempel, PhD

Associate Professor, Department of Pharmacology
Associate Professor, Department of Obstetrics and Gynecology
Scientific Program:Next-Generation Therapies
nuh7@psu.edu
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Research Interests

Dr. Nadine Hempel's research interests center on understanding molecular mechanisms that regulate metastasis and tumor recurrence of ovarian cancer, with the ultimate goal of identifying novel targets for therapy of advanced-stage disease.

Her research group uses a variety of molecular, cellular, imaging and in vivo techniques to focus on two research areas in ovarian cancer biology: first, the role of mitochondrial antioxidants and reactive oxygen species during metastatic progression; and second, the regulation of mitochondrial dynamics and metabolism in ovarian cancer.

  • Neoplasms
  • Oxidation-Reduction
  • Reactive Oxygen Species
  • Proteins
  • Ovarian Neoplasms
  • Neoplasm Metastasis
  • Enzymes
  • Urinary Bladder Neoplasms
  • Transforming Growth Factors
  • Genes
  • Superoxide Dismutase
  • Mitochondria

Recent Publications

2021

Worley, BL, Auen, T, Arnold, AC, Monia, BP, Hempel, N & Czyzyk, TA 2021, 'Antisense oligonucleotide-mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet-induced obesity in mice', Physiological reports, vol. 9, no. 9, e14853. https://doi.org/10.14814/phy2.14853
Emrich, SM, Yoast, RE, Xin, P, Arige, V, Wagner, LE, Hempel, N, Gill, DL, Sneyd, J, Yule, DI & Trebak, M 2021, 'Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling', Cell Reports, vol. 34, no. 9, 108760. https://doi.org/10.1016/j.celrep.2021.108760

2020

Pathak, T, Gueguinou, M, Walter, V, Delierneux, C, Johnson, MT, Zhang, X, Xin, P, Yoast, RE, Emrich, SM, Yochum, GS, Sekler, I, Koltun, WA, Gill, DL, Hempel, N & Trebak, M 2020, 'Dichotomous role of the human mitochondrial na+ /ca2+ /li+ exchanger nclx in colorectal cancer growth and metastasis', eLife, vol. 9, e59686, pp. 1-41. https://doi.org/10.7554/ELIFE.59686
Chang, C, Worley, BL, Phaëton, R & Hempel, N 2020, 'Extracellular glutathione peroxidase GPx3 and its role in cancer', Cancers, vol. 12, no. 8, 2197, pp. 1-20. https://doi.org/10.3390/cancers12082197
Johnson, MT, Gudlur, A, Zhang, X, Xin, P, Emrich, SM, Yoast, RE, Courjaret, R, Nwokonko, RM, Li, W, Hempel, N, Machaca, K, Gill, DL, Hogan, PG & Trebak, M 2020, 'L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 29, pp. 17369-17380. https://doi.org/10.1073/pnas.2007598117
Delierneux, C, Kouba, S, Shanmughapriya, S, Potier-Cartereau, M, Trebak, M & Hempel, N 2020, 'Mitochondrial Calcium Regulation of Redox Signaling in Cancer', Cells, vol. 9, no. 2. https://doi.org/10.3390/cells9020432
Yoast, RE, Emrich, SM, Zhang, X, Xin, P, Johnson, MT, Fike, AJ, Walter, V, Hempel, N, Yule, DI, Sneyd, J, Gill, DL & Trebak, M 2020, 'The native ORAI channel trio underlies the diversity of Ca2+ signaling events', Nature communications, vol. 11, no. 1, pp. 2444. https://doi.org/10.1038/s41467-020-16232-6

2019

Zhang, X, Pathak, T, Yoast, R, Emrich, S, Xin, P, Nwokonko, RM, Johnson, M, Wu, S, Delierneux, C, Gueguinou, M, Hempel, N, Putney, JW, Gill, DL & Trebak, M 2019, 'A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction', Nature communications, vol. 10, no. 1, 1971. https://doi.org/10.1038/s41467-019-09593-0
Kim, YS, Gupta Vallur, P, Jones, VM, Worley, BL, Shimko, S, Shin, DH, Crawford, LTC, Chen, CW, Aird, KM, Abraham, T, Shepherd, TG, Warrick, JI, Lee, NY, Phaeton, R, Mythreye, K & Hempel, N 2020, 'Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells', Oncogene, vol. 39, no. 8, pp. 1619-1633. https://doi.org/10.1038/s41388-019-1097-7
Emrich, SM, Yoast, RE, Xin, P, Zhang, X, Pathak, T, Nwokonko, R, Gueguinou, MF, Subedi, KP, Zhou, Y, Ambudkar, IS, Hempel, N, Machaca, K, Gill, DL & Trebak, M 2019, 'Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity', Journal of Biological Chemistry, vol. 294, no. 16, pp. 6318-6332. https://doi.org/10.1074/jbc.RA118.006801

2018

Worley, BL, Kim, YS, Mardini, J, Zaman, R, Leon, KE, Vallur, PG, Nduwumwami, A, Warrick, JI, Timmins, PF, Kesterson, JP, Phaëton, R, Lee, NY, Walter, V, Endres, L, Mythreye, K, Aird, KM & Hempel, N 2019, 'GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment', Redox Biology, vol. 25, 101051. https://doi.org/10.1016/j.redox.2018.11.009
Singh, P, Jenkins, LM, Horst, B, Alers, V, Pradhan, S, Kaur, P, Srivastava, T, Hempel, N, Gyorffy, B, Broude, EV, Lee, NY & Mythreye, K 2018, 'Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis', Cancer Research, vol. 78, no. 11, pp. 2978-2989. https://doi.org/10.1158/0008-5472.CAN-17-2316
Shah, N, Kumar, S, Zaman, N, Pan, CC, Bloodworth, JC, Lei, W, Streicher, JM, Hempel, N, Mythreye, K & Lee, NY 2018, 'TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth', Nature communications, vol. 9, no. 1, 1696. https://doi.org/10.1038/s41467-018-04121-y

2017

Engelberth, SA, Hempel, N & Bergkvist, M 2017, 'Cationic dendritic starch as a vehicle for photodynamic therapy and siRNA co-delivery', Journal of Photochemistry and Photobiology B: Biology, vol. 168, pp. 185-192. https://doi.org/10.1016/j.jphotobiol.2017.02.013
Russo, M, Broach, J, Sheldon, K, Houser, KR, Liu, DJ, Kesterson, J, Phaeton, R, Hossler, C, Hempel, N, Baker, M, Newell, JM, Zaino, R & Warrick, JI 2017, 'Clonal evolution in paired endometrial intraepithelial neoplasia/atypical hyperplasia and endometrioid adenocarcinoma', Human Pathology, vol. 67, pp. 69-77. https://doi.org/10.1016/j.humpath.2017.07.003
Kim, YS, Vallur, PG, Phaëton, R, Mythreye, K & Hempel, N 2017, 'Insights into the dichotomous regulation of SOD2 in cancer', Antioxidants, vol. 6, no. 4, 86. https://doi.org/10.3390/antiox6040086
Ben-Kasus Nissim, T, Zhang, X, Elazar, A, Roy, S, Stolwijk, JA, Zhou, Y, Motiani, RK, Gueguinou, M, Hempel, N, Hershfinkel, M, Gill, DL, Trebak, M & Sekler, I 2017, 'Mitochondria control store-operated Ca2+ entry through Na+ and redox signals', EMBO Journal, vol. 36, no. 6, pp. 797-815. https://doi.org/10.15252/embj.201592481

Clinical Trials Search


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