Researcher Profile

Researcher Profile

Nadine Hempel, PhD

Nadine Hempel, PhD

Associate Professor, Department of Pharmacology
Scientific Program:Experimental Therapeutics
nuh7@psu.edu
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Research Interests

Dr. Nadine Hempel's research interests center on understanding molecular mechanisms that regulate metastasis and tumor recurrence of ovarian cancer, with the ultimate goal of identifying novel targets for therapy of advanced-stage disease.

Her research group uses a variety of molecular, cellular, imaging and in vivo techniques to focus on two research areas in ovarian cancer biology: first, the role of mitochondrial antioxidants and reactive oxygen species during metastatic progression; and second, the regulation of mitochondrial dynamics and metabolism in ovarian cancer.

  • Neoplasms
  • Oxidation-Reduction
  • Ovarian Neoplasms
  • Reactive Oxygen Species
  • Urinary Bladder Neoplasms
  • Proteins
  • Enzymes
  • Transforming Growth Factors
  • Neoplasm Metastasis
  • Superoxide Dismutase
  • Genes
  • Growth Factor Receptors

Recent Publications

2019

Zhang, X, Pathak, T, Yoast, R, Emrich, S, Xin, P, Nwokonko, RM, Johnson, M, Wu, S, Delierneux, C, Gueguinou, M, Hempel, N, Putney, JW, Gill, D & Trebak, M 2019, 'A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction', Nature communications, vol. 10, no. 1, 1971. https://doi.org/10.1038/s41467-019-09593-0
Emrich, SM, Yoast, RE, Xin, P, Zhang, X, Pathak, T, Nwokonko, R, Gueguinou, MF, Subedi, KP, Zhou, Y, Ambudkar, IS, Hempel, N, Machaca, K, Gill, D & Trebak, M 2019, 'Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity' Journal of Biological Chemistry, vol. 294, no. 16, pp. 6318-6332. https://doi.org/10.1074/jbc.RA118.006801

2018

Worley, BL, Kim, YS, Mardini, J, Zaman, R, Leon, KE, Vallur, PG, Nduwumwami, A, Warrick, J, Timmins, PF, Kesterson, J, Phaeton, R, Lee, NY, Walter, V, Endres, L, Mythreye, K, Aird, K & Hempel, N 2018, 'GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment' Redox Biology. https://doi.org/10.1016/j.redox.2018.11.009
Singh, P, Jenkins, LM, Horst, B, Alers, V, Pradhan, S, Kaur, P, Srivastava, T, Hempel, N, Gyorffy, B, Broude, EV, Lee, NY & Mythreye, K 2018, 'Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis', Cancer Research, vol. 78, no. 11, pp. 2978-2989. https://doi.org/10.1158/0008-5472.CAN-17-2316
Shah, N, Kumar, S, Zaman, N, Pan, CC, Bloodworth, JC, Lei, W, Streicher, JM, Hempel, N, Mythreye, K & Lee, NY 2018, 'TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth', Nature communications, vol. 9, no. 1, 1696. https://doi.org/10.1038/s41467-018-04121-y

2017

Engelberth, SA, Hempel, N & Bergkvist, M 2017, 'Cationic dendritic starch as a vehicle for photodynamic therapy and siRNA co-delivery', Journal of Photochemistry and Photobiology B: Biology, vol. 168, pp. 185-192. https://doi.org/10.1016/j.jphotobiol.2017.02.013
Russo, M, Broach, J, Sheldon, K, Houser, KR, Liu, D, Kesterson, J, Phaeton, R, Hossler, C, Hempel, N, Baker, M, Newell, J, Zaino, R & Warrick, J 2017, 'Clonal evolution in paired endometrial intraepithelial neoplasia/atypical hyperplasia and endometrioid adenocarcinoma', Human Pathology, vol. 67, pp. 69-77. https://doi.org/10.1016/j.humpath.2017.07.003
Kim, YS, Vallur, PG, Phaeton, R, Mythreye, K & Hempel, N 2017, 'Insights into the dichotomous regulation of SOD2 in cancer', Antioxidants, vol. 6, no. 4, 86. https://doi.org/10.3390/antiox6040086
Ben-Kasus Nissim, T, Zhang, X, Elazar, A, Roy, S, Stolwijk, JA, Zhou, Y, Motiani, RK, Gueguinou, M, Hempel, N, Hershfinkel, M, Gill, D, Trebak, M & Sekler, I 2017, 'Mitochondria control store-operated Ca2+ entry through Na+ and redox signals', EMBO Journal, vol. 36, no. 6, pp. 797-815. https://doi.org/10.15252/embj.201592481

2016

Kumar, S, Pan, CC, Shah, N, Wheeler, SE, Hoyt, KR, Hempel, N, Mythreye, K & Lee, NY 2016, 'Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion', Molecular cell, vol. 62, no. 4, pp. 520-531. https://doi.org/10.1016/j.molcel.2016.04.010
Hempel, N & Trebak, M 2017, 'Crosstalk between calcium and reactive oxygen species signaling in cancer', Cell Calcium, vol. 63, pp. 70-96. https://doi.org/10.1016/j.ceca.2017.01.007
Zhang, J, Gao, Q, Zhou, Y, Dier, U, Hempel, N & Hochwald, SN 2016, 'Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis', Oncogene, vol. 35, no. 15, pp. 1926-1942. https://doi.org/10.1038/onc.2015.256

2015

Engelberth, SA, Hempel, N & Bergkvist, M 2015, 'Chemically Modified Dendritic Starch: A Novel Nanomaterial for siRNA Delivery' Bioconjugate Chemistry, vol. 26, no. 8, pp. 1766-1774. https://doi.org/10.1021/acs.bioconjchem.5b00313
Iuliano, JN, Kutscha, PD, Biderman, N, Subbaram, S, Groves, TR, Tenenbaum, SA & Hempel, N 2015, 'Metastatic bladder cancer cells distinctively sense and respond to physical cues of collagen fibril-mimetic nanotopography' Experimental Biology and Medicine, vol. 240, no. 5, pp. 601-610. https://doi.org/10.1177/1535370214560973
Hemachandra, LPMP, Shin, DH, Dier, U, Iuliano, JN, Engelberth, SA, Uusitalo, LM, Murphy, SK & Hempel, N 2015, 'Mitochondrial superoxide dismutase has a protumorigenic role in ovarian clear cell carcinoma' Cancer Research, vol. 75, no. 22, pp. 4973-4984. https://doi.org/10.1158/0008-5472.CAN-14-3799
Shin, DH, Dier, U, Melendez, JA & Hempel, N 2015, 'Regulation of MMP-1 expression in response to hypoxia is dependent on the intracellular redox status of metastatic bladder cancer cells', Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1852, no. 12, pp. 2593-2602. https://doi.org/10.1016/j.bbadis.2015.09.001

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)