Researcher Profile

Researcher Profile

Nadine Hempel, PhD

Nadine Hempel, PhD

Associate Professor, Department of Pharmacology
Scientific Program:Next-Generation Therapies
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Research Interests

Dr. Nadine Hempel's research interests center on understanding molecular mechanisms that regulate metastasis and tumor recurrence of ovarian cancer, with the ultimate goal of identifying novel targets for therapy of advanced-stage disease.

Her research group uses a variety of molecular, cellular, imaging and in vivo techniques to focus on two research areas in ovarian cancer biology: first, the role of mitochondrial antioxidants and reactive oxygen species during metastatic progression; and second, the regulation of mitochondrial dynamics and metabolism in ovarian cancer.

  • Neoplasms
  • Oxidation-Reduction
  • Ovarian Neoplasms
  • Reactive Oxygen Species
  • Urinary Bladder Neoplasms
  • Neoplasm Metastasis
  • Proteins
  • Enzymes
  • Transforming Growth Factors
  • Superoxide Dismutase
  • Genes
  • Growth Factor Receptors

Recent Publications


Zhang, X, Pathak, T, Yoast, R, Emrich, S, Xin, P, Nwokonko, RM, Johnson, M, Wu, S, Delierneux, C, Gueguinou, M, Hempel, N, Putney, JW, Gill, DL & Trebak, M 2019, 'A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction', Nature communications, vol. 10, no. 1, 1971.
Kim, YS, Gupta Vallur, P, Jones, VM, Worley, BL, Shimko, S, Shin, DH, Crawford, LTC, Chen, CW, Aird, KM, Abraham, T, Shepherd, TG, Warrick, JI, Lee, NY, Phaeton, R, Mythreye, K & Hempel, N 2020, 'Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells', Oncogene, vol. 39, no. 8, pp. 1619-1633.
Emrich, SM, Yoast, RE, Xin, P, Zhang, X, Pathak, T, Nwokonko, R, Gueguinou, MF, Subedi, KP, Zhou, Y, Ambudkar, IS, Hempel, N, Machaca, K, Gill, DL & Trebak, M 2019, 'Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity', Journal of Biological Chemistry, vol. 294, no. 16, pp. 6318-6332.


Worley, BL, Kim, YS, Mardini, J, Zaman, R, Leon, KE, Vallur, PG, Nduwumwami, A, Warrick, JI, Timmins, PF, Kesterson, JP, Phaëton, R, Lee, NY, Walter, V, Endres, L, Mythreye, K, Aird, KM & Hempel, N 2019, 'GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment', Redox Biology, vol. 25, 101051.
Singh, P, Jenkins, LM, Horst, B, Alers, V, Pradhan, S, Kaur, P, Srivastava, T, Hempel, N, Gyorffy, B, Broude, EV, Lee, NY & Mythreye, K 2018, 'Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis', Cancer Research, vol. 78, no. 11, pp. 2978-2989.
Shah, N, Kumar, S, Zaman, N, Pan, CC, Bloodworth, JC, Lei, W, Streicher, JM, Hempel, N, Mythreye, K & Lee, NY 2018, 'TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth', Nature communications, vol. 9, no. 1, 1696.


Engelberth, SA, Hempel, N & Bergkvist, M 2017, 'Cationic dendritic starch as a vehicle for photodynamic therapy and siRNA co-delivery', Journal of Photochemistry and Photobiology B: Biology, vol. 168, pp. 185-192.
Russo, M, Broach, J, Sheldon, K, Houser, KR, Liu, DJ, Kesterson, J, Phaeton, R, Hossler, C, Hempel, N, Baker, M, Newell, JM, Zaino, R & Warrick, JI 2017, 'Clonal evolution in paired endometrial intraepithelial neoplasia/atypical hyperplasia and endometrioid adenocarcinoma', Human Pathology, vol. 67, pp. 69-77.
Kim, YS, Vallur, PG, Phaëton, R, Mythreye, K & Hempel, N 2017, 'Insights into the dichotomous regulation of SOD2 in cancer', Antioxidants, vol. 6, no. 4, 86.
Ben-Kasus Nissim, T, Zhang, X, Elazar, A, Roy, S, Stolwijk, JA, Zhou, Y, Motiani, RK, Gueguinou, M, Hempel, N, Hershfinkel, M, Gill, DL, Trebak, M & Sekler, I 2017, 'Mitochondria control store-operated Ca2+ entry through Na+ and redox signals', EMBO Journal, vol. 36, no. 6, pp. 797-815.


Kumar, S, Pan, CC, Shah, N, Wheeler, SE, Hoyt, KR, Hempel, N, Mythreye, K & Lee, NY 2016, 'Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion', Molecular cell, vol. 62, no. 4, pp. 520-531.
Hempel, N & Trebak, M 2017, 'Crosstalk between calcium and reactive oxygen species signaling in cancer', Cell Calcium, vol. 63, pp. 70-96.
Zhang, J, Gao, Q, Zhou, Y, Dier, U, Hempel, N & Hochwald, SN 2016, 'Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis', Oncogene, vol. 35, no. 15, pp. 1926-1942.

Clinical Trials Search

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