Researcher Profile

Researcher Profile

Nadine Hempel, PhD

Nadine Hempel, PhD

Associate Professor, Department of Pharmacology
Associate Professor, Department of Obstetrics and Gynecology
Scientific Program:Next-Generation Therapies
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Research Interests

Dr. Nadine Hempel's research interests center on understanding molecular mechanisms that regulate metastasis and tumor recurrence of ovarian cancer, with the ultimate goal of identifying novel targets for therapy of advanced-stage disease.

Her research group uses a variety of molecular, cellular, imaging and in vivo techniques to focus on two research areas in ovarian cancer biology: first, the role of mitochondrial antioxidants and reactive oxygen species during metastatic progression; and second, the regulation of mitochondrial dynamics and metabolism in ovarian cancer.

  • Neoplasms
  • Oxidation-Reduction
  • Reactive Oxygen Species
  • Proteins
  • Ovarian Neoplasms
  • Neoplasm Metastasis
  • Enzymes
  • Urinary Bladder Neoplasms
  • Transforming Growth Factors
  • Genes
  • Superoxide Dismutase
  • Mitochondria

Recent Publications


Worley, BL, Auen, T, Arnold, AC, Monia, BP, Hempel, N & Czyzyk, TA 2021, 'Antisense oligonucleotide-mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet-induced obesity in mice', Physiological reports, vol. 9, no. 9, e14853.
Emrich, SM, Yoast, RE, Xin, P, Arige, V, Wagner, LE, Hempel, N, Gill, DL, Sneyd, J, Yule, DI & Trebak, M 2021, 'Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling', Cell Reports, vol. 34, no. 9, 108760.


Pathak, T, Gueguinou, M, Walter, V, Delierneux, C, Johnson, MT, Zhang, X, Xin, P, Yoast, RE, Emrich, SM, Yochum, GS, Sekler, I, Koltun, WA, Gill, DL, Hempel, N & Trebak, M 2020, 'Dichotomous role of the human mitochondrial na+ /ca2+ /li+ exchanger nclx in colorectal cancer growth and metastasis', eLife, vol. 9, e59686, pp. 1-41.
Chang, C, Worley, BL, Phaëton, R & Hempel, N 2020, 'Extracellular glutathione peroxidase GPx3 and its role in cancer', Cancers, vol. 12, no. 8, 2197, pp. 1-20.
Johnson, MT, Gudlur, A, Zhang, X, Xin, P, Emrich, SM, Yoast, RE, Courjaret, R, Nwokonko, RM, Li, W, Hempel, N, Machaca, K, Gill, DL, Hogan, PG & Trebak, M 2020, 'L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 29, pp. 17369-17380.
Delierneux, C, Kouba, S, Shanmughapriya, S, Potier-Cartereau, M, Trebak, M & Hempel, N 2020, 'Mitochondrial Calcium Regulation of Redox Signaling in Cancer', Cells, vol. 9, no. 2.
Yoast, RE, Emrich, SM, Zhang, X, Xin, P, Johnson, MT, Fike, AJ, Walter, V, Hempel, N, Yule, DI, Sneyd, J, Gill, DL & Trebak, M 2020, 'The native ORAI channel trio underlies the diversity of Ca2+ signaling events', Nature communications, vol. 11, no. 1, pp. 2444.


Zhang, X, Pathak, T, Yoast, R, Emrich, S, Xin, P, Nwokonko, RM, Johnson, M, Wu, S, Delierneux, C, Gueguinou, M, Hempel, N, Putney, JW, Gill, DL & Trebak, M 2019, 'A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction', Nature communications, vol. 10, no. 1, 1971.
Kim, YS, Gupta Vallur, P, Jones, VM, Worley, BL, Shimko, S, Shin, DH, Crawford, LTC, Chen, CW, Aird, KM, Abraham, T, Shepherd, TG, Warrick, JI, Lee, NY, Phaeton, R, Mythreye, K & Hempel, N 2020, 'Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells', Oncogene, vol. 39, no. 8, pp. 1619-1633.
Emrich, SM, Yoast, RE, Xin, P, Zhang, X, Pathak, T, Nwokonko, R, Gueguinou, MF, Subedi, KP, Zhou, Y, Ambudkar, IS, Hempel, N, Machaca, K, Gill, DL & Trebak, M 2019, 'Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity', Journal of Biological Chemistry, vol. 294, no. 16, pp. 6318-6332.


Worley, BL, Kim, YS, Mardini, J, Zaman, R, Leon, KE, Vallur, PG, Nduwumwami, A, Warrick, JI, Timmins, PF, Kesterson, JP, Phaëton, R, Lee, NY, Walter, V, Endres, L, Mythreye, K, Aird, KM & Hempel, N 2019, 'GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment', Redox Biology, vol. 25, 101051.
Singh, P, Jenkins, LM, Horst, B, Alers, V, Pradhan, S, Kaur, P, Srivastava, T, Hempel, N, Gyorffy, B, Broude, EV, Lee, NY & Mythreye, K 2018, 'Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis', Cancer Research, vol. 78, no. 11, pp. 2978-2989.
Shah, N, Kumar, S, Zaman, N, Pan, CC, Bloodworth, JC, Lei, W, Streicher, JM, Hempel, N, Mythreye, K & Lee, NY 2018, 'TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth', Nature communications, vol. 9, no. 1, 1696.


Engelberth, SA, Hempel, N & Bergkvist, M 2017, 'Cationic dendritic starch as a vehicle for photodynamic therapy and siRNA co-delivery', Journal of Photochemistry and Photobiology B: Biology, vol. 168, pp. 185-192.
Russo, M, Broach, J, Sheldon, K, Houser, KR, Liu, DJ, Kesterson, J, Phaeton, R, Hossler, C, Hempel, N, Baker, M, Newell, JM, Zaino, R & Warrick, JI 2017, 'Clonal evolution in paired endometrial intraepithelial neoplasia/atypical hyperplasia and endometrioid adenocarcinoma', Human Pathology, vol. 67, pp. 69-77.
Kim, YS, Vallur, PG, Phaëton, R, Mythreye, K & Hempel, N 2017, 'Insights into the dichotomous regulation of SOD2 in cancer', Antioxidants, vol. 6, no. 4, 86.
Ben-Kasus Nissim, T, Zhang, X, Elazar, A, Roy, S, Stolwijk, JA, Zhou, Y, Motiani, RK, Gueguinou, M, Hempel, N, Hershfinkel, M, Gill, DL, Trebak, M & Sekler, I 2017, 'Mitochondria control store-operated Ca2+ entry through Na+ and redox signals', EMBO Journal, vol. 36, no. 6, pp. 797-815.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)