Researcher Profile

Researcher Profile

Craig Eugene Cameron, PhD

Craig Eugene Cameron, PhD

Eberly Family Chair Professor, Biochemistry & Molecular Biology
Eberly Family Chair, Biochemistry & Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis
cec9@psu.edu

Research Interests

  • RNA Replicase
  • Proteins
  • Poliovirus
  • RNA
  • Nucleotides
  • Antiviral Agents
  • Enzymes
  • Viral RNA
  • Viruses
  • RNA Viruses
  • Hepacivirus
  • DNA-Directed RNA Polymerases

Recent Publications

2019

Woodman, A, Lee, KM, Janissen, R, Gong, YN, Dekker, NH, Shih, SR & Cameron, CE 2019, 'Predicting intraserotypic recombination in enterovirus 71', Journal of virology, vol. 93, no. 4, e0205718. https://doi.org/10.1128/JVI.02057-18
Li, C, Wang, H, Shi, J, Yang, D, Zhou, G, Chang, J, Cameron, CE, Woodman, A & Yu, L 2019, 'Senecavirus-specific recombination assays reveal the intimate link between polymerase fidelity and RNA recombination', Journal of virology, vol. 93, no. 13, e00576-19. https://doi.org/10.1128/JVI.00576-19

2018

Gizzi, AS, Grove, TL, Arnold, JJ, Jose, J, Jangra, RK, Garforth, SJ, Du, Q, Cahill, SM, Dulyaninova, NG, Love, JD, Chandran, K, Bresnick, AR, Cameron, CE & Almo, SC 2018, 'A naturally occurring antiviral ribonucleotide encoded by the human genome', Nature, vol. 558, no. 7711, pp. 610-614. https://doi.org/10.1038/s41586-018-0238-4
Fitzsimmons, WJ, Woods, RJ, McCrone, JT, Woodman, A, Arnold, JJ, Yennawar, M, Evans, R, Cameron, CE & Lauring, AS 2018, 'A speed–fidelity trade-off determines the mutation rate and virulence of an RNA virus', PLoS biology, vol. 16, no. 6, e2006459. https://doi.org/10.1371/journal.pbio.2006459
Lee, KM, Gong, YN, Hsieh, TH, Woodman, A, Dekker, NH, Cameron, CE & Shih, SR 2018, 'Discovery of Enterovirus A71-like nonstructural genomes in recent circulating viruses of the Enterovirus A species', Emerging Microbes and Infections, vol. 7, no. 1, 111. https://doi.org/10.1038/s41426-018-0107-0
Gizzi, AS, Grove, TL, Arnold, JJ, Jose, J, Jangra, RK, Garforth, SJ, Du, Q, Cahill, SM, Dulyaninova, NG, Love, JD, Chandran, K, Bresnick, AR, Cameron, CE & Almo, SC 2018, 'Erratum to: A naturally occurring antiviral ribonucleotide encoded by the human genome (Nature, (2018), 558, 7711, (610-614), 10.1038/s41586-018-0238-4)' Nature, vol. 562, no. 7725, pp. E3. https://doi.org/10.1038/s41586-018-0355-0
Li, C, Wang, H, Yuan, T, Woodman, A, Yang, D, Zhou, G, Cameron, CE & Yu, L 2018, 'Foot-and-mouth disease virus type O specific mutations determine RNA-dependent RNA polymerase fidelity and virus attenuation', Virology, vol. 518, pp. 87-94. https://doi.org/10.1016/j.virol.2018.01.030
Banerjee, S, Aponte-Diaz, D, Yeager, C, Sharma, SD, Ning, G, Oh, HS, Han, Q, Umeda, M, Hara, Y, Wang, RYL & Cameron, CE 2018, 'Hijacking of multiple phospholipid biosynthetic pathways and induction of membrane biogenesis by a picornaviral 3CD protein', PLoS Pathogens, vol. 14, no. 5, e1007086. https://doi.org/10.1371/journal.ppat.1007086
Arena, G, Cissé, MY, Pyrdziak, S, Chatre, L, Riscal, R, Fuentes, M, Arnold, JJ, Kastner, M, Gayte, L, Bertrand-Gaday, C, Nay, K, Angebault-Prouteau, C, Murray, K, Chabi, B, Koechlin-Ramonatxo, C, Orsetti, B, Vincent, C, Casas, F, Marine, JC, Etienne-Manneville, S, Bernex, F, Lombès, A, Cameron, CE, Dubouchaud, H, Ricchetti, M, Linares, LK & Le Cam, L 2018, 'Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53', Molecular cell, vol. 69, no. 4, pp. 594-609.e8. https://doi.org/10.1016/j.molcel.2018.01.023
Oh, HS, Banerjee, S, Aponte-Diaz, D, Sharma, SD, Aligo, J, Lodeiro, MF, Ning, G, Sharma, R, Arnold, JJ & Cameron, CE 2018, 'Multiple poliovirus-induced organelles suggested by comparison of spatiotemporal dynamics of membranous structures and phosphoinositides', PLoS Pathogens, vol. 14, no. 4, e1007036. https://doi.org/10.1371/journal.ppat.1007036
Arnold, JJ & Cameron, CE 2018, Predicting Off-Target Effects of Therapeutic Antiviral Ribonucleosides: Inhibition of Mitochondrial RNA Transcription. in Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. vol. 1-2, wiley, pp. 407-417. https://doi.org/10.1002/9781119329725.ch26
Guo, L, Sharma, SD, Debes, J, Beisang, D, Rattenbacher, B, Louis, IVS, Wiesner, DL, Cameron, CE & Bohjanen, PR 2018, 'The hepatitis C viral nonstructural protein 5A stabilizes growth-regulatory human transcripts', Nucleic acids research, vol. 46, no. 5, pp. 2537-2547. https://doi.org/10.1093/nar/gky061

2017

Murugesapillai, D, Bouaziz, S, Maher, LJ, Israeloff, NE, Cameron, CE & Williams, MC 2017, 'Accurate nanoscale flexibility measurement of DNA and DNA-protein complexes by atomic force microscopy in liquid', Nanoscale, vol. 9, no. 31, pp. 11327-11337. https://doi.org/10.1039/c7nr04231k
Li, S, Ma, F, Bachman, H, Cameron, CE, Zeng, X & Huang, TJ 2017, 'Acoustofluidic bacteria separation', Journal of Micromechanics and Microengineering, vol. 27, no. 1, 015031. https://doi.org/10.1088/1361-6439/27/1/015031
Griesemer, SB, Kramer, LD, van Slyke, GA, Pata, JD, Gohara, DW, Cameron, CE & Ciota, AT 2017, 'Mutagen resistance and mutation restriction of St. Louis encephalitis virus', Journal of General Virology, vol. 98, no. 2, 000682, pp. 201-211. https://doi.org/10.1099/jgv.0.000682
Shengjuler, D, Sun, S, Cremer, PS & Cameron, CE 2017, 'PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions', Journal of visualized experiments : JoVE, no. 125. https://doi.org/10.3791/55869
Dulin, D, Arnold, JJ, van Laar, T, Oh, HS, Lee, C, Perkins, AL, Harki, DA, Depken, M, Cameron, CE & Dekker, NH 2017, 'Signatures of Nucleotide Analog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers', Cell Reports, vol. 21, no. 4, pp. 1063-1076. https://doi.org/10.1016/j.celrep.2017.10.005
Guo, F, Li, S, Caglar, MU, Mao, Z, Liu, W, Woodman, A, Arnold, JJ, Wilke, CO, Huang, TJ & Cameron, CE 2017, 'Single-Cell Virology: On-Chip Investigation of Viral Infection Dynamics', Cell Reports, vol. 21, no. 6, pp. 1692-1704. https://doi.org/10.1016/j.celrep.2017.10.051
Shengjuler, D, Chan, YM, Sun, S, Moustafa, I, Li, ZL, Gohara, DW, Buck, M, Cremer, PS, Boehr, DD & Cameron, CE 2017, 'The RNA-Binding Site of Poliovirus 3C Protein Doubles as a Phosphoinositide-Binding Domain', Structure, vol. 25, no. 12, pp. 1875-1886.e7. https://doi.org/10.1016/j.str.2017.11.001
Yang, X, Liu, X, Musser, DM, Moustafa, I, Arnold, JJ, Cameron, CE & Boehr, DD 2017, 'Triphosphate reorientation of the incoming nucleotide as a fidelity checkpoint in viral RNA-dependent RNA Polymerases', Journal of Biological Chemistry, vol. 292, no. 9, pp. 3810-3826. https://doi.org/10.1074/jbc.M116.750638
Huang, PN, Jheng, JR, Arnold, JJ, Wang, JR, Cameron, CE & Shih, SR 2017, 'UGGT1 enhances enterovirus 71 pathogenicity by promoting viral RNA synthesis and viral replication', PLoS Pathogens, vol. 13, no. 5, e1006375. https://doi.org/10.1371/journal.ppat.1006375
Uchida, A, Murugesapillai, D, Kastner, M, Wang, Y, Lodeiro, MF, Prabhakar, S, Oliver, GV, Arnold, JJ, Maher, LJ, Williams, MC & Cameron, CE 2017, 'Unexpected sequences and structures of mtDNA required for efficient transcription from the first heavy-strand promoter', eLife, vol. 6, e27283. https://doi.org/10.7554/eLife.27283

2016

Li, S, Ren, L, Huang, PH, Yao, X, Cuento, RA, McCoy, JP, Cameron, CE, Levine, SJ & Huang, TJ 2016, 'Acoustofluidic Transfer of Inflammatory Cells from Human Sputum Samples', Analytical Chemistry, vol. 88, no. 11, pp. 5655-5661. https://doi.org/10.1021/acs.analchem.5b03383
Woodman, A, Arnold, JJ, Cameron, CE & Evans, DJ 2016, 'Biochemical and genetic analysis of the role of the viral polymerase in enterovirus recombination', Nucleic acids research, vol. 44, no. 14, pp. 6883-6895. https://doi.org/10.1093/nar/gkw567
Baumgart, BR, Wang, F, Kwagh, J, Storck, C, Euler, C, Fuller, M, Simic, D, Sharma, SD, Arnold, JJ, Cameron, CE, Van Vleet, TR, Flint, O, Bunch, RT, Davies, MH, Graziano, MJ & Sanderson, TP 2016, 'Effects of BMS-986094, a guanosine nucleotide analogue, on mitochondrial DNA synthesis and function', Toxicological Sciences, vol. 153, no. 2, pp. 396-408. https://doi.org/10.1093/toxsci/kfw135
Gajewski, JP, Arnold, JJ, Salminen, TS, Kaguni, LS & Cameron, CE 2016, Expression and purification of mitochondrial RNA polymerase and transcription factor a from drosophila melanogaster. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1351, Humana Press Inc., pp. 199-210. https://doi.org/10.1007/978-1-4939-3040-1_15
Cameron, CE, Moustafa, I & Arnold, JJ 2016, Fidelity of Nucleotide Incorporation by the RNA-Dependent RNA Polymerase from Poliovirus. in LS Kaguni & MT Oliveira (eds), DNA Replication Across Taxa, 2016. Enzymes, vol. 39, Academic Press, pp. 293-323. https://doi.org/10.1016/bs.enz.2016.02.002
Chan, YM, Moustafa, I, Arnold, JJ, Cameron, CE & Boehr, DD 2016, 'Long-Range Communication between Different Functional Sites in the Picornaviral 3C Protein' Structure, vol. 24, no. 4, pp. 509-517. https://doi.org/10.1016/j.str.2016.02.019
Oran, AR, Adams, CM, Zhang, XY, Gennaro, VJ, Pfeiffer, HK, Mellert, HS, Seidel, HE, Mascioli, K, Kaplan, J, Gaballa, MR, Shen, C, Rigoutsos, I, King, MP, Cotney, JL, Arnold, JJ, Sharma, SD, Martinez-Outschoorn, UE, Vakoc, CR, Chodosh, LA, Thompson, JE, Bradner, JE, Cameron, CE, Shadel, GS, Eischen, CM & McMahon, SB 2016, 'Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer', Oncotarget, vol. 7, no. 45, pp. 72395-72414. https://doi.org/10.18632/oncotarget.11718
Lee, CA, August, A, Arnold, JJ & Cameron, CE 2016, Polymerase mechanism-based method of viral attenuation. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1349, Humana Press Inc., pp. 83-104. https://doi.org/10.1007/978-1-4939-3008-1_6

2015

Moustafa, I, Gohara, DW, Uchida, A, Yennawar, N & Cameron, CE 2015, 'Conformational ensemble of the poliovirus 3CD precursor observed by MD simulations and confirmed by SAXS: A strategy to expand the viral proteome?', Viruses, vol. 7, no. 11, pp. 5962-5986. https://doi.org/10.3390/v7112919
Reynolds, KA, Cameron, CE & Raney, KD 2015, 'Melting of Duplex DNA in the Absence of ATP by the NS3 Helicase Domain through Specific Interaction with a Single-Strand/Double-Strand Junction', Biochemistry, vol. 54, no. 27, pp. 4248-4258. https://doi.org/10.1021/acs.biochem.5b00214
Liu, X, Musser, DM, Lee, CA, Yang, X, Arnold, JJ, Cameron, CE & Boehr, DD 2015, 'Nucleobase but not sugar fidelity is maintained in the Sabin I RNA-dependent RNA polymerase' Viruses, vol. 7, no. 10, A26, pp. 5571-5586. https://doi.org/10.3390/v7102894
Van Slyke, GA, Arnold, JJ, Lugo, AJ, Griesemer, SB, Moustafa, I, Kramer, LD, Cameron, CE & Ciota, AT 2015, 'Sequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in Mosquitoes', PLoS Pathogens, vol. 11, no. 6, e1005009. https://doi.org/10.1371/journal.ppat.1005009
Li, S, Ding, X, Mao, Z, Chen, Y, Nama, N, Guo, F, Li, P, Wang, L, Cameron, CE & Huang, TJ 2015, 'Standing surface acoustic wave (SSAW)-based cell washing', Lab on a Chip, vol. 15, no. 1, pp. 331-338. https://doi.org/10.1039/c4lc00903g
Moustafa, I, Uchida, A, Wang, Y, Yennawar, N & Cameron, CE 2015, 'Structural models of mammalian mitochondrial transcription factor B2' Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, vol. 1849, no. 8, pp. 987-1002. https://doi.org/10.1016/j.bbagrm.2015.05.010
Kolli, S, Meng, X, Wu, X, Shengjuler, D, Cameron, CE, Xiang, Y & Deng, J 2015, 'Structure-function analysis of vaccinia virus H7 protein reveals a novel phosphoinositide binding fold essential for poxvirus replication', Journal of virology, vol. 89, no. 4, pp. 2209-2219. https://doi.org/10.1128/JVI.03073-14
van der Linden, L, Vives-Adrián, L, Selisko, B, Ferrer-Orta, C, Liu, X, Lanke, K, Ulferts, R, De Palma, AM, Tanchis, F, Goris, N, Lefebvre, D, De Clercq, K, Leyssen, P, Lacroix, C, Pürstinger, G, Coutard, B, Canard, B, Boehr, DD, Arnold, JJ, Cameron, CE, Verdaguer, N, Neyts, J & van Kuppeveld, FJM 2015, 'The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family', PLoS pathogens, vol. 11, no. 3, e1004733, pp. 1-23. https://doi.org/10.1371/journal.ppat.1004733

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