Hodgkin Lymphoma

Lymphoma is a cancer of the lymph nodes, glands that help the body fight infection. There are two main kinds of lymphoma: 

  • Hodgkin lymphoma
  • Non-Hodgkin lymphoma

Hodgkin lymphomas contain particular cells - called Reed Sternberg cells - that can be seen under a microscope. These cells are not present in non-Hodgkin lymphomas.

Hodgkin lymphoma is usually a disease of early adulthood (most patients are in their 20s). The risk rises again in adults over 55. 

The disease typically spreads from lymph node to lymph node.

Treatment

A combination of chemotherapy and radiation are effective treatments for Hodgkin lymphoma. Smaller doses tend to work best for younger patients and have fewer side effects. 

Treatments can be more challenging for older patients. If the disease comes back after treatment, a stem cell transplant using the patient’s own stem cells may be the best option. 

There are also newer treatments being developed.

Care Team

You may see one or more of the following specialists for your cancer treatment.
David Claxton, MD David Claxton, MD Malignant Hematologist View Researcher Profile
W. Christopher Ehmann, MD W. Christopher Ehmann, MD Malignant Hematologist View Researcher Profile
Raymond Hohl, MD, PhD Raymond Hohl, MD, PhD Malignant Hematologist View Researcher Profile
Heath Mackley, MD Heath Mackley, MD Radiation Oncologist View Researcher Profile
Seema Naik, MD Seema Naik, MD Malignant Hematologist View Researcher Profile
Witold Rybka, MD, FRCPC Witold Rybka, MD, FRCPC Malignant Hematologist View Researcher Profile
Henry Wagner Jr., MD Henry Wagner Jr., MD Radiation Oncologist View Researcher Profile
Hong Zheng, MD, PhD Hong Zheng, MD, PhD Malignant Hematologist View Researcher Profile
Shin Mineishi, MD Shin Mineishi, MD View Researcher Profile
Kevin L. Rakszawski, MD Kevin L. Rakszawski, MD View Researcher Profile

Locations

Cancer Care Partnership

Cancer Care Partnership

1800 E Park Ave
Entrance E
State College, PA 16803

Phone: 814-231-7800
Penn State Cancer Institute

Penn State Cancer Institute

400 University Dr
Hershey, PA 17033

Phone: 717-531-6585
Penn State Health Medical Group - St Joseph Medical Center

Penn State Health Medical Group - St Joseph Medical Center

2494 Bernville Rd
Suite 106
Reading, PA 19605

Phone: 610-898-1800

Clinical Trials

A Phase III Randomized, Open Label, Multi-center Study of the Safety and Efficacy of Apixaban for Thromboembolism Prevention versus No Systemic Anticoagulant Prophylaxis during Induction Chemotherapy in Children with Newly Diagnosed Acute Lymphoblastic Leukemia (ALL) or Lymphoma (T or B cell) Treated with Pegylated Asparaginase
Risk-based, response-adapted, Phase II open-label trial of nivolumab + brentuximab vedotin (N + Bv) for children, adolescents, and young adults with relapsed/refractory (R/R) CD30 + classic Hodgkin lymphoma (cHL) after failure of first-line therapy, followed by brentuximab + bendamustine (Bv + B) for participants with a suboptimal response. CheckMate 744: CHECKpoint pathway and nivolumab clinical Trial Evaluation

Groups, Classes and Support

Support groups offer an opportunity to connect with other patients, caregivers and families. Learn more about support groups offered at Penn State Cancer Institute.

Prevention and Screening

We don’t know the exact cause of Hodgkin lymphoma. In some patients, the disease may be caused by a common virus. Others may have something wrong with their immune system. 

The best screening for Hodgkin lymphomas is done by patients. If you notice an enlarged lymph node (gland), call your physician.

Symptoms and Diagnosis

Lymphoma is a cancer of the lymph nodes, glands that help the body fight infection.

Symptoms

Symptoms of Hodgkin lymphoma include:

  • Swelling of lymph nodes (glands) in the neck, armpit, groin or under the chin 
  • Severe itching after drinking alcohol
  • Fever that doesn’t go away
  • Drenching night sweats
  • Unexplained weight loss 

If you have any of these symptoms, call your doctor.

Diagnosis requires a biopsy of the affected area by a surgeon. This is a minor procedure that causes little discomfort or risk to the patient.

The tissue is examined under a microscope and tested to determine which type of cells are growing abnormally.

Hodgkin Lymphoma

Lymphoma is a cancer of the lymph nodes, glands that help the body fight infection. There are two main kinds of lymphoma: 

  • Hodgkin lymphoma
  • Non-Hodgkin lymphoma

Hodgkin lymphomas contain particular cells - called Reed Sternberg cells - that can be seen under a microscope. These cells are not present in non-Hodgkin lymphomas.

Hodgkin lymphoma is usually a disease of early adulthood (most patients are in their 20s). The risk rises again in adults over 55. 

The disease typically spreads from lymph node to lymph node.

A combination of chemotherapy and radiation are effective treatments for Hodgkin lymphoma. Smaller doses tend to work best for younger patients and have fewer side effects. 

Treatments can be more challenging for older patients. If the disease comes back after treatment, a stem cell transplant using the patient’s own stem cells may be the best option. 

There are also newer treatments being developed.

You may see one or more of the following specialists for your cancer treatment.
David Claxton, MD David Claxton, MD Malignant Hematologist View Researcher Profile
W. Christopher Ehmann, MD W. Christopher Ehmann, MD Malignant Hematologist View Researcher Profile
Raymond Hohl, MD, PhD Raymond Hohl, MD, PhD Malignant Hematologist View Researcher Profile
Heath Mackley, MD Heath Mackley, MD Radiation Oncologist View Researcher Profile
Seema Naik, MD Seema Naik, MD Malignant Hematologist View Researcher Profile
Witold Rybka, MD, FRCPC Witold Rybka, MD, FRCPC Malignant Hematologist View Researcher Profile
Henry Wagner Jr., MD Henry Wagner Jr., MD Radiation Oncologist View Researcher Profile
Hong Zheng, MD, PhD Hong Zheng, MD, PhD Malignant Hematologist View Researcher Profile
Shin Mineishi, MD Shin Mineishi, MD View Researcher Profile
Kevin L. Rakszawski, MD Kevin L. Rakszawski, MD View Researcher Profile
Cancer Care Partnership

Cancer Care Partnership

1800 E Park Ave
Entrance E
State College, PA 16803

Phone: 814-231-7800
Penn State Cancer Institute

Penn State Cancer Institute

400 University Dr
Hershey, PA 17033

Phone: 717-531-6585
Penn State Health Medical Group - St Joseph Medical Center

Penn State Health Medical Group - St Joseph Medical Center

2494 Bernville Rd
Suite 106
Reading, PA 19605

Phone: 610-898-1800
A Phase III Randomized, Open Label, Multi-center Study of the Safety and Efficacy of Apixaban for Thromboembolism Prevention versus No Systemic Anticoagulant Prophylaxis during Induction Chemotherapy in Children with Newly Diagnosed Acute Lymphoblastic Leukemia (ALL) or Lymphoma (T or B cell) Treated with Pegylated Asparaginase
Risk-based, response-adapted, Phase II open-label trial of nivolumab + brentuximab vedotin (N + Bv) for children, adolescents, and young adults with relapsed/refractory (R/R) CD30 + classic Hodgkin lymphoma (cHL) after failure of first-line therapy, followed by brentuximab + bendamustine (Bv + B) for participants with a suboptimal response. CheckMate 744: CHECKpoint pathway and nivolumab clinical Trial Evaluation
Support groups offer an opportunity to connect with other patients, caregivers and families. Learn more about support groups offered at Penn State Cancer Institute.

We don’t know the exact cause of Hodgkin lymphoma. In some patients, the disease may be caused by a common virus. Others may have something wrong with their immune system. 

The best screening for Hodgkin lymphomas is done by patients. If you notice an enlarged lymph node (gland), call your physician.

Lymphoma is a cancer of the lymph nodes, glands that help the body fight infection.

Symptoms

Symptoms of Hodgkin lymphoma include:

  • Swelling of lymph nodes (glands) in the neck, armpit, groin or under the chin 
  • Severe itching after drinking alcohol
  • Fever that doesn’t go away
  • Drenching night sweats
  • Unexplained weight loss 

If you have any of these symptoms, call your doctor.

Diagnosis requires a biopsy of the affected area by a surgeon. This is a minor procedure that causes little discomfort or risk to the patient.

The tissue is examined under a microscope and tested to determine which type of cells are growing abnormally.