Bone Marrow Transplantation

A bone and marrow transplantation is special treatment for individuals with certain types of cancers. It is also called a bone marrow transplant or a hematopoietic stem cell transplant (HSCT). 

Bone marrow helps make blood stem cells, including white blood cells, red blood cells and platelets. Bone and marrow transplants replace unhealthy marrow with healthy marrow.

An estimated 50,000 individuals receive HSCT every year.

You will get chemotherapy and/or radiation to kill unhealthy cells before your transplant. Then, healthy cells are given to you through an intravenous (IV) line or a tube. The new cells will grow and make healthy blood cells in your marrow.

Treatment

Our experienced team at Penn State Cancer Institute performs 150-180 procedures each year. We offer the three main types of bone and marrow transplantations:

  • Autologous transplants
  • Allogeneic transplants
  • Haploidentical transplants

Autologous Transplants

Autologous transplants, or autologous HSCTs, use your own blood stem cells for the transplant rather than a donor’s. We collect, freeze and store your stem cells for use later. Once blood cells are collected, you will get high-dose chemotherapy to kill diseased cells. Then, your stem cells will be given back to you through an IV. This can happen months or even years after the initial transplant.

Allogeneic Transplants

Allogeneic transplants use healthy blood stem cells from someone else. Sometimes stem cells come from a relative. A close match offers a lower risk of side effects and complications after transplant.

You will receive conditioning treatments, called chemoradiotherapy, before your transplant. This helps kill cancer cells and suppress your immune system. Suppressing your immune system is important to help your body accept the transplanted blood stem cells. 

Donor cells can be infused through an IV after conditioning treatments are complete. Side effects of allogeneic stem cell transplants may include graft-versus-host disease (GVHD). You will be monitored closely for signs of GVHD. It can be treated with medication and other therapies.

Haploidentical Transplants

A haploidentical transplant is a type of allogeneic transplant that does not offer a close match. Donated cells often come from a family member when a close match cannot be found. This is a newer type of transplant.

Care Team

You may see one or more of the following specialists for your cancer treatment.
David Claxton, MD David Claxton, MD Hematologist View Researcher Profile
W. Christopher Ehmann, MD W. Christopher Ehmann, MD Hematologist View Researcher Profile
Raymond Hohl, MD, PhD Raymond Hohl, MD, PhD Hematologist View Researcher Profile
Heath Mackley, MD, FACRO Heath Mackley, MD, FACRO Radiation Oncologist View Researcher Profile
Shin Mineishi, MD Shin Mineishi, MD Hematologist View Researcher Profile
Seema Naik, MD Seema Naik, MD Hematologist View Researcher Profile
Witold Rybka, MD, FRCPC Witold Rybka, MD, FRCPC Hematologist View Researcher Profile
Henry Wagner Jr., MD Henry Wagner Jr., MD Radiation Oncologist View Researcher Profile
Hong Zheng, MD, PhD Hong Zheng, MD, PhD Hematologist View Researcher Profile

Locations

Bone and marrow transplantation is an inpatient procedure. Our unit is located on the seventh floor of the Penn State Cancer Institute.
Penn State Cancer Institute

Penn State Cancer Institute

400 University Dr
Hershey, PA 17033

Phone: 717-531-6585

Clinical Trials

Groups, Classes and Support

All patients, caregivers, friends and family are invited to join us for light refreshments and an open discussion about bone marrow/stem cell transplant. No RSVP necessary. Learn more about the Penn State Cancer Institute’s Bone Marrow/Stem Cell Transplant support group.

Prevention and Screening

Care After Your Bone and Marrow Transplantation

Your care team will continue to closely monitor you after your procedure. Regular tests will help your team see how your body is responding to the transplant and how quickly your bone marrow is producing new blood stem cells. You may need to stay in the hospital a few weeks, depending on how your body responds.

Your care team will also help you manage side effects after the transplant. Side effects may include nausea and diarrhea.

You will also need to be careful to avoid exposure to germs. A common cold can create serious complications after a bone and marrow stem cell transplant. Your care team will give you guidelines that help keep you healthy.

Symptoms and Diagnosis

A bone and marrow transplantation is special treatment for individuals with certain types of cancers.

Symptoms

Is a Bone and Marrow Transplant Right for Me?

Hematopoietic stem cell transplants (bone marrow transplants) are used when aggressive blood cancers, diseases or genetic disorders have not responded to conventional treatments. It may be used to treat diseases such as:

  • Acute leukemia
  • Multiple myeloma
  • Lymphoma

Your oncologist will decide if a bone and marrow transplant is an effective treatment option for you. Your oncologist may recommend stem cell transplantation based on your:

  • Age
  • Past treatment and outcomes
  • Personal and family medical history
  • Family support system
  • Personal motivation to take care of yourself throughout the transplant process

If you have questions or need a referral to the Penn State Cancer Institute, please call 717-531-6585option 1.

Bone Marrow Transplantation

A bone and marrow transplantation is special treatment for individuals with certain types of cancers. It is also called a bone marrow transplant or a hematopoietic stem cell transplant (HSCT). 

Bone marrow helps make blood stem cells, including white blood cells, red blood cells and platelets. Bone and marrow transplants replace unhealthy marrow with healthy marrow.

An estimated 50,000 individuals receive HSCT every year.

You will get chemotherapy and/or radiation to kill unhealthy cells before your transplant. Then, healthy cells are given to you through an intravenous (IV) line or a tube. The new cells will grow and make healthy blood cells in your marrow.

Our experienced team at Penn State Cancer Institute performs 150-180 procedures each year. We offer the three main types of bone and marrow transplantations:

  • Autologous transplants
  • Allogeneic transplants
  • Haploidentical transplants

Autologous Transplants

Autologous transplants, or autologous HSCTs, use your own blood stem cells for the transplant rather than a donor’s. We collect, freeze and store your stem cells for use later. Once blood cells are collected, you will get high-dose chemotherapy to kill diseased cells. Then, your stem cells will be given back to you through an IV. This can happen months or even years after the initial transplant.

Allogeneic Transplants

Allogeneic transplants use healthy blood stem cells from someone else. Sometimes stem cells come from a relative. A close match offers a lower risk of side effects and complications after transplant.

You will receive conditioning treatments, called chemoradiotherapy, before your transplant. This helps kill cancer cells and suppress your immune system. Suppressing your immune system is important to help your body accept the transplanted blood stem cells. 

Donor cells can be infused through an IV after conditioning treatments are complete. Side effects of allogeneic stem cell transplants may include graft-versus-host disease (GVHD). You will be monitored closely for signs of GVHD. It can be treated with medication and other therapies.

Haploidentical Transplants

A haploidentical transplant is a type of allogeneic transplant that does not offer a close match. Donated cells often come from a family member when a close match cannot be found. This is a newer type of transplant.

You may see one or more of the following specialists for your cancer treatment.
David Claxton, MD David Claxton, MD Hematologist View Researcher Profile
W. Christopher Ehmann, MD W. Christopher Ehmann, MD Hematologist View Researcher Profile
Raymond Hohl, MD, PhD Raymond Hohl, MD, PhD Hematologist View Researcher Profile
Heath Mackley, MD, FACRO Heath Mackley, MD, FACRO Radiation Oncologist View Researcher Profile
Shin Mineishi, MD Shin Mineishi, MD Hematologist View Researcher Profile
Seema Naik, MD Seema Naik, MD Hematologist View Researcher Profile
Witold Rybka, MD, FRCPC Witold Rybka, MD, FRCPC Hematologist View Researcher Profile
Henry Wagner Jr., MD Henry Wagner Jr., MD Radiation Oncologist View Researcher Profile
Hong Zheng, MD, PhD Hong Zheng, MD, PhD Hematologist View Researcher Profile
Bone and marrow transplantation is an inpatient procedure. Our unit is located on the seventh floor of the Penn State Cancer Institute.
Penn State Cancer Institute

Penn State Cancer Institute

400 University Dr
Hershey, PA 17033

Phone: 717-531-6585
All patients, caregivers, friends and family are invited to join us for light refreshments and an open discussion about bone marrow/stem cell transplant. No RSVP necessary. Learn more about the Penn State Cancer Institute’s Bone Marrow/Stem Cell Transplant support group.

Care After Your Bone and Marrow Transplantation

Your care team will continue to closely monitor you after your procedure. Regular tests will help your team see how your body is responding to the transplant and how quickly your bone marrow is producing new blood stem cells. You may need to stay in the hospital a few weeks, depending on how your body responds.

Your care team will also help you manage side effects after the transplant. Side effects may include nausea and diarrhea.

You will also need to be careful to avoid exposure to germs. A common cold can create serious complications after a bone and marrow stem cell transplant. Your care team will give you guidelines that help keep you healthy.

A bone and marrow transplantation is special treatment for individuals with certain types of cancers.

Symptoms

Is a Bone and Marrow Transplant Right for Me?

Hematopoietic stem cell transplants (bone marrow transplants) are used when aggressive blood cancers, diseases or genetic disorders have not responded to conventional treatments. It may be used to treat diseases such as:

  • Acute leukemia
  • Multiple myeloma
  • Lymphoma

Your oncologist will decide if a bone and marrow transplant is an effective treatment option for you. Your oncologist may recommend stem cell transplantation based on your:

  • Age
  • Past treatment and outcomes
  • Personal and family medical history
  • Family support system
  • Personal motivation to take care of yourself throughout the transplant process

If you have questions or need a referral to the Penn State Cancer Institute, please call 717-531-6585option 1.