Bladder Cancer

Cancer of the bladder is the fourth most common cancer among men and is in the top 10 most common cancers among women in the United States. Bladder cancer is typically found in older people - usually around age 65. It is uncommon for people younger than 40 to develop bladder cancer. 

The American Cancer Society estimates that around 79,030 new cases of bladder cancer will be diagnosed in 2017. They also estimate that roughly 16,870 people will die from this type of cancer each year. 

Types of Bladder Cancer

The most common type of bladder cancer is called urothelial carcinoma. It can begin in the bladder, the renal pelvis (where the ureter meets the kidney), the ureter or the urethra. Urothelial cancer most commonly starts from the inner bladder wall.

Less common types of bladder cancer include: 

  • Squamous cell carcinoma
  • Adenocarcinoma
  • Small cell cancer
  • Lymphoma
  • Sarcoma

Treatment

Penn State Cancer Institute has a team of doctors and other health care providers who specialize in the treatment of bladder cancer. This cancer team works together closely to make the diagnosis and determine the best treatment options for each bladder cancer patient. 

Treatment of bladder cancer is customized to each patient, and may include:

  • Surgery
  • Radiation therapy
  • Medical therapy

Surgery

Most bladder cancer patients will need surgery to help treat their cancer. Your doctor will talk to you about the type of surgery that is right for your specific cancer. Surgical procedures may include a transurethral resection of the bladder tumor (TURBT) or a radial cystectomy.

  • Transurethral resection of the bladder tumor (TURBT). You will be asleep during a TURBT procedure. Your surgeon will place a small scope through the urinary opening and into the bladder. The surgeon will work from the inside to remove bladder cancer. This minimally invasive procedure does not require an incision. You may need a catheter to drain urine for a few days after the procedure. 
  • Radical cystectomy. One in four patients will need a radical cystectomy to treat bladder cancer. Your surgeon will make an incision in the lower abdomen to remove your bladder. Then, your surgeon will reconstruct the urinary tract. Sometimes, the bladder can be rebuilt. This procedure is called a neobladder operation. Many patients, however, will have an external bag for urine. Your urologist will talk to you about each of these procedures, and what is best for you. 

Radiation Therapy

Radiation therapy is also sometimes used to treat bladder cancer. You will meet with a radiation oncologist to talk about the risks and benefits of radiation. Your doctor will also explain what to expect during radiation therapy. 

A machine aims high-energy rays from outside the body to the specific location of the tumor. This can be done with precision so that radiation does not damage other areas of the body. Most patients have radiation daily for about five to seven weeks. The length and frequency of your radiation will depend on your specific cancer. 

Daily sessions last about 15-30 minutes. Before you start radiation, you will attend a treatment planning session. The radiation therapists will make a cast for you, which will help hold you in position during your radiation sessions. Imaging tests, including a CT scan and an MRI, may be run. These tests help identify the precise location of your tumor. You will be given a very small tattoo to show the radiation therapist exactly where to aim the external radiation beam during your session. 

The entire planning session will take 2 1/2 hours. Be sure to follow all your doctor’s orders before your planning session. It may affect your treatment start date if you do not listen to instructions prior to your appointment. 

Medical Therapy

Some patients with bladder cancer may need chemotherapy or immunotherapy. These treatments kill cancer cells everywhere in your body. Your medical oncologist will talk to you about the plan that is right for you. 

You will need a complete physical exam before starting either of these treatments to check your blood counts, heart strength and overall health. 

Chemotherapy and immunotherapy are given in the Penn State Cancer Infusion Therapy location which is located in the Cancer Institute adjacent to the main entrance to the Medical Center in Suite T1300. Our staff will bring you to an infusion room, where you will receive your treatment. Medicine is injected directly into your blood stream through an intravenous line. Treatment can take anywhere from two to five hours, depending on your specific plan. A team of medical professionals will monitor you throughout your treatment to check for side effects. 

Care Team

You may see one or more of the following specialists for your cancer treatment.

Joseph Drabick, MD Joseph Drabick, MD Medical Oncologist View Researcher Profile
Sheldon Holder, PhD, MD Sheldon Holder, PhD, MD Medical Oncologist View Researcher Profile
Monika Joshi, MD, MRCP Monika Joshi, MD, MRCP Medical Oncologist View Researcher Profile
Matthew G. Kaag, MD Matthew G. Kaag, MD Surgeon View Researcher Profile
Heath Mackley, MD Heath Mackley, MD Radiation Oncologist View Researcher Profile
Suzanne Merrill, MD Suzanne Merrill, MD Surgeon View Researcher Profile
Jay Raman, MD Jay Raman, MD Surgeon View Researcher Profile
Marc Rovito, MD Marc Rovito, MD Hematology/Oncologist View Researcher Profile
Nabeel Sarwani, MD Nabeel Sarwani, MD Radiologist View Researcher Profile
Leonard Tuanquin, MD Leonard Tuanquin, MD Radiation Oncologist View Researcher Profile
Nicholas Zaorsky, MD Nicholas Zaorsky, MD Radiation Oncologist View Researcher Profile

Locations

We provide specialized care for urologic oncology patients of central Pennsylvania in a setting that’s easily accessible for patients and referring providers.
Penn State Health Medical Group - Nyes Road Specialties

Penn State Health Medical Group - Nyes Road Specialties

121 N Nyes Rd
Suite C
Harrisburg, PA 17112

Phone: 717-657-4045
Penn State Health Surgery Specialties

Penn State Health Surgery Specialties

200 Campus
Suite 3100
Hershey, PA 17033

Phone: 717-531-8887

Clinical Trials

A Phase 1b-2 Study to Evaluate Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Erdafitinib plus JNJ-63723283, an Anti PD-1 Monoclonal Antibody, in Subjects with Metastatic or Surgically Unresectable Urothelial Cancer with Selected FGFR Gene Alterations.
A Phase 2b, Single-Arm, Multicenter Trial to Evaluate the Efficacy and Safety of UGN-102 as Primary Chemoablative Therapy in Patients with Low Grade (LG) Non-Muscle-Invasive Bladder Cancer (NMIBC) at Intermediate Risk of Recurrence

Groups, Classes and Support

Support groups provide an opportunity to share your feelings and connect with others. Penn State Cancer Institute offers many breakout sessions led by the medical team, bladder cancer survivors and caregivers. These sessions offer information and support about living with bladder cancer, including treatment, the role of a support person and more. Anyone affected by this disease, including patients, family and friends, is invited to attend.

Learn more about our Bladder Cancer Support Group.

Prevention and Screening

Early detection is key to effectively treating bladder cancer. If you are at risk of developing bladder cancer, talk to your doctor about how you can lower your risk. Risk factors for bladder cancer include:

Gender (Bladder cancer is three times more common in males than females.)

  • Smoking
  • Family history of bladder cancer
  • Regular exposure to certain chemicals:
    • Benzidine
    • Beta-napthylamine
    • Rubber
    • Leather
    • Textiles
    • Paint manufacturing
    • Printing

There is no standardized screening for bladder cancer similar to those for some other types of cancer. However, there are tests that can detect the early stages of bladder cancer. If you are at risk for developing bladder cancer, you should talk to your doctor about these screenings.

Symptoms and Diagnosis

Cancer of the bladder is the fourth most common cancer among men and is in the top 10 most common cancers among women in the United States.

Symptoms

Symptoms of bladder cancer include:

  • Blood in the urine (hematuria)
  • Pain during urination or more frequent urination
  • Pain in the lower part of abdomen or back

Diagnosis

If you experience any of these symptoms, schedule an appointment with your doctor. Your doctor will do a complete examination, including asking about your personal and family medical history and a physical exam. You will also have a urinalysis, where a sample of urine will be collected and checked for blood or other abnormalities.

You may also need additional diagnostic testing, including:

These tests will help your urologic oncologist understand the extent of your cancer. After your tests are complete, you and your doctor will work together to create a treatment plan that is right for you.

Bladder Cancer

Cancer of the bladder is the fourth most common cancer among men and is in the top 10 most common cancers among women in the United States. Bladder cancer is typically found in older people - usually around age 65. It is uncommon for people younger than 40 to develop bladder cancer. 

The American Cancer Society estimates that around 79,030 new cases of bladder cancer will be diagnosed in 2017. They also estimate that roughly 16,870 people will die from this type of cancer each year. 

Types of Bladder Cancer

The most common type of bladder cancer is called urothelial carcinoma. It can begin in the bladder, the renal pelvis (where the ureter meets the kidney), the ureter or the urethra. Urothelial cancer most commonly starts from the inner bladder wall.

Less common types of bladder cancer include: 

  • Squamous cell carcinoma
  • Adenocarcinoma
  • Small cell cancer
  • Lymphoma
  • Sarcoma

Penn State Cancer Institute has a team of doctors and other health care providers who specialize in the treatment of bladder cancer. This cancer team works together closely to make the diagnosis and determine the best treatment options for each bladder cancer patient. 

Treatment of bladder cancer is customized to each patient, and may include:

  • Surgery
  • Radiation therapy
  • Medical therapy

Surgery

Most bladder cancer patients will need surgery to help treat their cancer. Your doctor will talk to you about the type of surgery that is right for your specific cancer. Surgical procedures may include a transurethral resection of the bladder tumor (TURBT) or a radial cystectomy.

  • Transurethral resection of the bladder tumor (TURBT). You will be asleep during a TURBT procedure. Your surgeon will place a small scope through the urinary opening and into the bladder. The surgeon will work from the inside to remove bladder cancer. This minimally invasive procedure does not require an incision. You may need a catheter to drain urine for a few days after the procedure. 
  • Radical cystectomy. One in four patients will need a radical cystectomy to treat bladder cancer. Your surgeon will make an incision in the lower abdomen to remove your bladder. Then, your surgeon will reconstruct the urinary tract. Sometimes, the bladder can be rebuilt. This procedure is called a neobladder operation. Many patients, however, will have an external bag for urine. Your urologist will talk to you about each of these procedures, and what is best for you. 

Radiation Therapy

Radiation therapy is also sometimes used to treat bladder cancer. You will meet with a radiation oncologist to talk about the risks and benefits of radiation. Your doctor will also explain what to expect during radiation therapy. 

A machine aims high-energy rays from outside the body to the specific location of the tumor. This can be done with precision so that radiation does not damage other areas of the body. Most patients have radiation daily for about five to seven weeks. The length and frequency of your radiation will depend on your specific cancer. 

Daily sessions last about 15-30 minutes. Before you start radiation, you will attend a treatment planning session. The radiation therapists will make a cast for you, which will help hold you in position during your radiation sessions. Imaging tests, including a CT scan and an MRI, may be run. These tests help identify the precise location of your tumor. You will be given a very small tattoo to show the radiation therapist exactly where to aim the external radiation beam during your session. 

The entire planning session will take 2 1/2 hours. Be sure to follow all your doctor’s orders before your planning session. It may affect your treatment start date if you do not listen to instructions prior to your appointment. 

Medical Therapy

Some patients with bladder cancer may need chemotherapy or immunotherapy. These treatments kill cancer cells everywhere in your body. Your medical oncologist will talk to you about the plan that is right for you. 

You will need a complete physical exam before starting either of these treatments to check your blood counts, heart strength and overall health. 

Chemotherapy and immunotherapy are given in the Penn State Cancer Infusion Therapy location which is located in the Cancer Institute adjacent to the main entrance to the Medical Center in Suite T1300. Our staff will bring you to an infusion room, where you will receive your treatment. Medicine is injected directly into your blood stream through an intravenous line. Treatment can take anywhere from two to five hours, depending on your specific plan. A team of medical professionals will monitor you throughout your treatment to check for side effects. 

You may see one or more of the following specialists for your cancer treatment.

Joseph Drabick, MD Joseph Drabick, MD Medical Oncologist View Researcher Profile
Sheldon Holder, PhD, MD Sheldon Holder, PhD, MD Medical Oncologist View Researcher Profile
Monika Joshi, MD, MRCP Monika Joshi, MD, MRCP Medical Oncologist View Researcher Profile
Matthew G. Kaag, MD Matthew G. Kaag, MD Surgeon View Researcher Profile
Heath Mackley, MD Heath Mackley, MD Radiation Oncologist View Researcher Profile
Suzanne Merrill, MD Suzanne Merrill, MD Surgeon View Researcher Profile
Jay Raman, MD Jay Raman, MD Surgeon View Researcher Profile
Marc Rovito, MD Marc Rovito, MD Hematology/Oncologist View Researcher Profile
Nabeel Sarwani, MD Nabeel Sarwani, MD Radiologist View Researcher Profile
Leonard Tuanquin, MD Leonard Tuanquin, MD Radiation Oncologist View Researcher Profile
Nicholas Zaorsky, MD Nicholas Zaorsky, MD Radiation Oncologist View Researcher Profile
We provide specialized care for urologic oncology patients of central Pennsylvania in a setting that’s easily accessible for patients and referring providers.
Penn State Health Medical Group - Nyes Road Specialties

Penn State Health Medical Group - Nyes Road Specialties

121 N Nyes Rd
Suite C
Harrisburg, PA 17112

Phone: 717-657-4045
Penn State Health Surgery Specialties

Penn State Health Surgery Specialties

200 Campus
Suite 3100
Hershey, PA 17033

Phone: 717-531-8887
A Phase 1b-2 Study to Evaluate Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Erdafitinib plus JNJ-63723283, an Anti PD-1 Monoclonal Antibody, in Subjects with Metastatic or Surgically Unresectable Urothelial Cancer with Selected FGFR Gene Alterations.
A Phase 2b, Single-Arm, Multicenter Trial to Evaluate the Efficacy and Safety of UGN-102 as Primary Chemoablative Therapy in Patients with Low Grade (LG) Non-Muscle-Invasive Bladder Cancer (NMIBC) at Intermediate Risk of Recurrence

Support groups provide an opportunity to share your feelings and connect with others. Penn State Cancer Institute offers many breakout sessions led by the medical team, bladder cancer survivors and caregivers. These sessions offer information and support about living with bladder cancer, including treatment, the role of a support person and more. Anyone affected by this disease, including patients, family and friends, is invited to attend.

Learn more about our Bladder Cancer Support Group.

Early detection is key to effectively treating bladder cancer. If you are at risk of developing bladder cancer, talk to your doctor about how you can lower your risk. Risk factors for bladder cancer include:

Gender (Bladder cancer is three times more common in males than females.)

  • Smoking
  • Family history of bladder cancer
  • Regular exposure to certain chemicals:
    • Benzidine
    • Beta-napthylamine
    • Rubber
    • Leather
    • Textiles
    • Paint manufacturing
    • Printing

There is no standardized screening for bladder cancer similar to those for some other types of cancer. However, there are tests that can detect the early stages of bladder cancer. If you are at risk for developing bladder cancer, you should talk to your doctor about these screenings.

Cancer of the bladder is the fourth most common cancer among men and is in the top 10 most common cancers among women in the United States.

Symptoms

Symptoms of bladder cancer include:

  • Blood in the urine (hematuria)
  • Pain during urination or more frequent urination
  • Pain in the lower part of abdomen or back

Diagnosis

If you experience any of these symptoms, schedule an appointment with your doctor. Your doctor will do a complete examination, including asking about your personal and family medical history and a physical exam. You will also have a urinalysis, where a sample of urine will be collected and checked for blood or other abnormalities.

You may also need additional diagnostic testing, including:

These tests will help your urologic oncologist understand the extent of your cancer. After your tests are complete, you and your doctor will work together to create a treatment plan that is right for you.